Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Mark, Orcholski"'
Autor:
Tsukasa Shimauchi, Olivier Boucherat, Tetsuro Yokokawa, Yann Grobs, WenHui Wu, Mark Orcholski, Sandra Martineau, Junichi Omura, Eve Tremblay, Kana Shimauchi, Valérie Nadeau, Sandra Breuils-Bonnet, Roxane Paulin, François Potus, Steeve Provencher, Sébastien Bonnet
Publikováno v:
JACC: Basic to Translational Science. 7:384-403
The authors show that increased poly(adenosine diphosphate-ribose) polymerase 1 (PARP1) and pyruvate kinase muscle isozyme 2 (PKM2) expression is a common feature of a decompensated right ventricle in patients with pulmonary arterial hypertension and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246bb85dc13ed096d9328c3bce296223
https://doi.org/10.1016/j.jacbts.2022.01.005
https://doi.org/10.1016/j.jacbts.2022.01.005
Autor:
Junichi Omura, Sandra Breuils-Bonnet, Eve Tremblay, Alice Bourgeois, Steeve Provencher, Yann Grobs, Tsukasa Shimauchi, Geraldine Vitry, Wen-Hui Wu, Victoria Toro, Mark Orcholski, Roxane Paulin, Sandra Martineau, Valérie Nadeau, Sébastien Bonnet, Pasquale Ferraro, Charlotte Romanet, François Potus, Olivier Boucherat
Publikováno v:
Thorax. 77:247-258
BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterised by exuberant tissue remodelling and associated with high unmet medical needs. Outcomes are even worse when IPF results in secondary pulmonary hypertension (PH). Imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ae239beee2050e9a91d1c3a7d936c9a
https://doi.org/10.1136/thoraxjnl-2021-217377
https://doi.org/10.1136/thoraxjnl-2021-217377
Autor:
Hannah N. De Jong, Frederick E. Dewey, Pablo Cordero, Rachelle A. Victorio, Anna Kirillova, Yong Huang, Roshni Madhvani, Kinya Seo, Andreas A. Werdich, Feng Lan, Mark Orcholski, W. Robert Liu, Ayca Erbilgin, Matthew T. Wheeler, Rui Chen, Stephen Pan, Young M. Kim, Krishna Bommakanti, Cherisse A. Marcou, J. Martijn Bos, Francois Haddad, Michael Ackerman, Ramachandran S. Vasan, Calum MacRae, Joseph C. Wu, Vinicio de Jesus Perez, Michael Snyder, Victoria N. Parikh, Euan A. Ashley
Publikováno v:
Circulation. Genomic and precision medicine. 15(4)
Background: The study of hypertrophic cardiomyopathy (HCM) can yield insight into the mechanisms underlying the complex trait of cardiac hypertrophy. To date, most genetic variants associated with HCM have been found in sarcomeric genes. Here, we des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f0fcc68f4c72fd0014e7176e8c9c55
https://pubmed.ncbi.nlm.nih.gov/35671065
https://pubmed.ncbi.nlm.nih.gov/35671065
Autor:
Ananya Chakraborty, Abinaya Nathan, Mark Orcholski, Stuti Agarwal, Elya A. Shamskhou, Natasha Auer, Ankita Mitra, Eleana Stephanie Guardado, Gowri Swaminathan, David F. Condon, Joyce Yu, Matthew McCarra, Nicholas H. Juul, Alden Mallory, Roberto A. Guzman-Hernandez, Ke Yuan, Vanesa Rojas, Joseph T. Crossno, Lai-Ming Yung, Paul B. Yu, Thomas Spencer, Robert A. Winn, Andrea Frump, Vijaya Karoor, Tim Lahm, Haley Hedlin, Jeffrey R. Fineman, Robert Lafyatis, Carsten N. F. Knutsen, Cristina M. Alvira, David N. Cornfield, Vinicio A. de Jesus Perez
Publikováno v:
European Respiratory Journal. :2201625
IntroductionPulmonary arterial hypertension (PAH) is characterized by loss of microvessels. The Wnt pathways control pulmonary angiogenesis, but their role in PAH is incompletely understood. We hypothesized that Wnt activation in pulmonary microvascu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3e8bc719814c03d20616a6c7d3c2bcf
https://doi.org/10.1183/13993003.01625-2022
https://doi.org/10.1183/13993003.01625-2022
Autor:
Yann Grobs, Sarah-eve Lemay, Charlotte Romanet, Sandra Breuils Bonnet, Mark Orcholski, Alice Bourgeois, Melanie Sauvaget, Kana Shimauchi, Pierre Voisine, Roxane Paulin, Francois Potus, Steeve Provencher, Olivier BOUCHERAT, Sebastien Bonnet
Publikováno v:
Circulation. 144
Vascular remodeling diseases (VRD) like coronary artery diseases or in-stent restenosis are characterized by proliferative and apoptosis-resistant vascular smooth muscle cells (VSMCs). As in cancer, proliferative VSMCs have increased Warburg effect l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a39af1f4c7744c683bd727270c153a3
https://doi.org/10.1161/circ.144.suppl_1.13184
https://doi.org/10.1161/circ.144.suppl_1.13184
Autor:
Sarah-eve Lemay, Charifa Awada, Victoria Toro, Charlotte Romanet, Mark Orcholski, Roxane Paulin, Steeve Provencher, Sebastien Bonnet, Olivier BOUCHERAT, François Potus
Publikováno v:
Circulation. 144
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by the elevation of mean pulmonary arterial pressure and resistance, culminating in right ventricular failure and premature death. Pulmonary artery smooth muscle cells (PASM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::729d7a5d2ce485524bf9da5cd6cda6d4
https://doi.org/10.1161/circ.144.suppl_1.10742
https://doi.org/10.1161/circ.144.suppl_1.10742
Autor:
Tsukasa Shimauchi, Wenhui Wu, Yann Grobs, Junichi Omura, Eve Tremblay, Sandra Martineau, Tetsuro Yokokawa, Kana Shimauchi, Valerie Nadeau, Sandra Breuils Bonnet, Mark Orcholski, Roxane Paulin, Francois Potus, Olivier BOUCHERAT, Steeve Provencher, Sebastien Bonnet
Publikováno v:
Circulation. 144
Introduction: Right ventricular (RV) function is the poor prognosis factor in pulmonary arterial hypertension (PAH) patients. Inflammation, oxidative DNA damage, and glycolysis are key triggering pathways that induce cardiomyocytes (CM) dysfunction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c18ff04913c435e84256cec93b6d00cc
https://doi.org/10.1161/circ.144.suppl_1.10231
https://doi.org/10.1161/circ.144.suppl_1.10231
Autor:
Ananya Chakraborty, Abinaya Nathan, Stuti Agarwal, Mark Orcholski, Ke Yuan, Sandra Bonnet, Sebastien Bonnet, Vinicio A Dejesus Perez
Publikováno v:
Circulation. 144
Introduction: Pulmonary arterial hypertension (PAH) is characterized by endothelial dysfunction and progressive loss of lung microvessels. Our group has shown that Wnt pathways are critical for pulmonary angiogenesis but the role of the Wnt/planar ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e68de01d03e436bf37053e05d2ab85d
https://doi.org/10.1161/circ.144.suppl_1.13476
https://doi.org/10.1161/circ.144.suppl_1.13476
Autor:
Swathi Balaji, Carlos Medina, Mark Orcholski, Paul L. Bollyky, Sundeep G. Keswani, Ananya Chakraborty, Gernot Kaber, Abinaya Nathan, Ke Yuan, Michael J. Kratochvil, Nadine Nagy, Vinicio A. de Jesus Perez, Ben Danielson, Elya A. Shamskhou, Emily H. Steen, Max Gao
Publikováno v:
Biomaterials
Idiopathic pulmonary fibrosis (IPF) is a life-threatening progressive lung disorder with limited therapeutic options. While interleukin-10 (IL-10) is a potent anti-inflammatory and anti-fibrotic cytokine, its utility in treating lung fibrosis has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02dde19582f5eab3341c64072b6668a
https://doi.org/10.1016/j.biomaterials.2019.02.017
https://doi.org/10.1016/j.biomaterials.2019.02.017
Autor:
Marie-Claude Lampron, Yann Grobs, Roxane Paulin, Geraldine Vitry, Olivier Boucherat, Sébastien Bonnet, Steeve Provencher, Mark Orcholski
Publikováno v:
Circulation. 142
Background: Pulmonary arterial hypertension (PAH) is a rapidly progressing disease of the lung vasculature, characterized by the remodeling of small pulmonary arteries in which pulmonary arterial smooth muscle cells (PASMCs) exhibit a cancer-like phe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e084c0ef0a27a62377f9475a58b374c
https://doi.org/10.1161/circ.142.suppl_3.17233
https://doi.org/10.1161/circ.142.suppl_3.17233