Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Mark, Lovdahl"'
Autor:
Jie Jack Li, Lain-Yen Hu, Mark Lovdahl, Daniel Y. Du, Brian Samas, Iula Donna Michele, Mark L. Boys, Garrett S. Hoge, Elena M. Drummond, Matthew Carroll, Danielle Dettling, William Glen Harter, Veerabahu Shanmugasundaram, Jeffrey Asbill, Maria N. Nguyen, Theresa Krieger-Burke, Wen-Song Yue, Bruce Allen Lefker, Susan Ciotti, Kimberly Jane Wade, Zhi Wang, Theodore R. Johnson, Jennifer A. Van Camp, Mary Ann Meade
Publikováno v:
Journal of Medicinal Chemistry. 51:7010-7014
4-((1 R,2 R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile [PF-0998425, (-)- 6a] is a novel, nonsteroidal androgen receptor antagonist for sebum control and treatment of androgenetic alopecia. It is potent, selective, and active in vivo. The co
Autor:
Danielle Dettling, Jeffrey Asbill, Victor Fedij, Derek Vrieze, David Pocalyko, Wen Song Yue, Radhika Yalamanchili, Drago Sliskovic, Jie Jack Li, Catherine R. Kostlan, Theodore R. Johnson, Lain Yen Hu, Susan Ciotti, Matthew Carroll, Huangshu John Lei, Daniel Du, Brian Samas, Howard Welgus, Kimberly Jane Wade, Kimberly Lapham, Teresa Krieger-Burke, Mark Lovdahl, Conglin Fan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5693-5697
A series of amino-pyridines were synthesized and evaluated for androgen antagonist activities. Among these compounds, (R)-(+)-6-[methyl-(1-phenyl-ethyl)-amino]-4-trifluoromethyl-nicotinonitrile was the most active example of this class. This compound
Publikováno v:
The Journal of Organic Chemistry. 72:6606-6609
The indium(III)-catalyzed Markovnikov addition of active methylene compounds to terminal alkynes has been expanded further to include diethyl acetamidomalonate. This reaction has been studied, and a practical approach to β-branched α-amino acids wa
Publikováno v:
Tetrahedron. 61:7807-7813
The indium(III) triflate mediated addition of active methylene compounds to terminal alkynes has been expanded to use malonates and low boiling terminal alkynes to form the Markovnikov addition products. Indium(III) chloride and indium(III) bromide w
Autor:
Zhijian Zhu, Jerry D. Clark, Norm L. Colbry, Alison Acciacca, Mark Lovdahl, Vladimir Beylin, Kenneth E. Mennen, Daniel Belmont
Publikováno v:
Organic Process Research & Development. 11:907-909
Convergent synthesis of 8-fluoronaphthalen-1-ylamine (6) was achieved through the reaction of 1H-naphtho[1,8-de][1,2,3]triazine (15) with HF-pyridine under mild conditions. This new synthesis for the preparation of 6 overcame many scale-up challenges
Publikováno v:
Tetrahedron Letters. 39:1083-1086
Various silyl-capped nucleophiles have been shown to be reactive as the final components in ArS mediated coupling of two alkyl vinyl ether units and carbon nucleophile and thus a fairly general procedure for the assemblage of polyfunctinal compounds
Autor:
William A. Smit, Tiffany Johnson, M. I. Lazareva, Yu. K. Kryschenko, A. Hayford, Alexander D. Dilman, R. Caple, Irina P. Smoliakova, Mark Lovdahl
Publikováno v:
ChemInform. 28
The use of allyl silanes and silyl vinyl ethers in the final step of a Lewis acid-mediated sequence involving reaction of ArSCl, two vinyl ether units and a C-nucleophile has been studied, thereby allowing introduction of functional groups into the f
Publikováno v:
ChemInform. 29
Various silyl-capped nucleophiles have been shown to be reactive as the final components in ArS mediated coupling of two alkyl vinyl ether units and carbon nucleophile and thus a fairly general procedure for the assemblage of polyfunctinal compounds
Publikováno v:
The Journal of organic chemistry. 72(17)
The indium(III)-catalyzed Markovnikov addition of active methylene compounds to terminal alkynes has been expanded further to include diethyl acetamidomalonate. This reaction has been studied, and a practical approach to beta-branched alpha-amino aci
Publikováno v:
ChemInform. 36
The indium(III) triflate mediated addition of active methylene compounds to terminal alkynes has been expanded to use malonates and low boiling terminal alkynes to form the Markovnikov addition products. Indium(III) chloride and indium(III) bromide w