Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Mark, Jimenez"'
Autor:
Hayden Nichols, Mark Jimenez, Zachary Goddard, Michael Sparapany, Byron Boots, Anirban Mazumdar
Publikováno v:
IEEE Robotics and Automation Letters. 7:4267-4274
Autor:
Travis Mandel, Mark Jimenez, Emily Risley, Taishi Nammoto, Rebekka Williams, Max Panoff, Meynard Ballesteros, Bobbie Suarez
Publikováno v:
Pattern Recognition. 135:109107
Publikováno v:
Analytical Chemistry. 87:7180-7186
A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method is described that employs a novel derivatization reagent for the measurement of serum estradiol (E2), with simultaneous analysis of underivatized testosterone (T) and dihydrotestoster
Autor:
Reena Desai, Kirsty A Walters, David J. Handelsman, Charles M. Allan, Dannielle H. Upton, Emily K. Colvin, Emily S. Fuller, Mark Jimenez, Viive M. Howell
Publikováno v:
Hormones and Cancer. 6:142-152
BRCA1 mutations are associated with ovarian cancer. Previous studies reported that murine granulosa cell (GC) Brca1 loss caused ovarian-uterine tumors resembling serous cystadenomas, but the pathogenesis of these tumors may have been confounded by ec
Autor:
Jeremy Troy Smith, Kirsty A Walters, David J. Handelsman, Melissa C Edwards, Dijana Tesic, Mark Jimenez, Aimee S L Caldwell
Publikováno v:
Neuroendocrinology. 106(4)
The androgen receptor (AR) is expressed throughout the hypothalamic-pituitary-gonadal (HPG) axis, and findings from female global AR knockout mice confirm that AR-mediated androgen actions play important roles in regulating female reproductive functi
Autor:
Melissa C Edwards, Robert B. Gilchrist, Kirsty A Walters, Reena Desai, Aimee S L Caldwell, David J. Handelsman, Mark Jimenez
Publikováno v:
Proceedings of the National Academy of Sciences. 114
Polycystic ovary syndrome (PCOS) is a complex hormonal disorder characterized by reproductive, endocrine, and metabolic abnormalities. As the origins of PCOS remain unknown, mechanism-based treatments are not feasible and current management relies on
Autor:
Gideon Sartorius, Graham R D Jones, David J. Handelsman, Robert I McLachlan, Julie D. Newman, Mark Jimenez
Publikováno v:
Clinical Chemistry. 60:510-517
BACKGROUNDSteroid immunoassays originally required solvent extraction, chromatography, and structurally authentic tracers to avoid interference from steroid cross-reactivity and matrix effects. The demand for steroid assays has driven assay simplific
Autor:
Charles M. Allan, Dannielle H. Upton, Rasmani Hazra, Reena Desai, David J. Handelsman, Mark Jimenez
Publikováno v:
Endocrinology. 155:1120-1130
We determined the functional role of the Sertoli cell glucocorticoid receptor (GR) in vivo using a transgenic Cre-loxP approach to conditionally disrupt GR expression. Sertoli cell GR knockout (SCGRKO) was shown by absent Sertoli cell-specific GR imm
Autor:
Jeremy Troy Smith, Mark Jimenez, Kirsty A Walters, Reena Desai, Charles M. Allan, Shai R. Joseph, Guang Ning, Xiaobing B. Cheng, David J. Handelsman, Linda J. Middleton
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 305:E717-E726
Homozygous androgen receptor (AR)-knockout (ARKO) female mice are subfertile due to both intra- and extraovarian (neuroendocrine) defects as defined by ovary transplantation. Using ARKO mice, this study set out to reveal the precise AR-regulated path
Publikováno v:
Endocrinology. 154:3410-3422
We recently created a mouse model displaying precocious Sertoli cell (SC) and spermatogenic development induced by SC-specific transgenic androgen receptor expression (TgSCAR). Here we reveal that TgSCAR regulates the development, function, and absol