Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Mark, Hsieh"'
Autor:
Rachel L. Palte, Veronica Juan, Yacob Gomez-Llorente, Marc Andre Bailly, Kalyan Chakravarthy, Xun Chen, Daniel Cipriano, Laurence Fayadat-Dilman, Symon Gathiaka, Heiko Greb, Brian Hall, Mas Handa, Mark Hsieh, Esther Kofman, Heping Lin, J. Richard Miller, Nhung Nguyen, Jennifer O’Neil, Hussam Shaheen, Eric Sterner, Corey Strickland, Angie Sun, Shane Taremi, Giovanna Scapin
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Palte et al provide cryo-EM structures of five potent and inhibitory monoclonal antibodies bound to human Arginase 1, a T-cell modulating metalloenzyme and a cancer drug target. They provide structural insights that will aid in the evaluation of thes
Externí odkaz:
https://doaj.org/article/fbf41ee3e220482a9ea5fcab675f2be6
Autor:
Rachel L. Palte, Veronica Juan, Yacob Gomez-Llorente, Marc Andre Bailly, Kalyan Chakravarthy, Xun Chen, Daniel Cipriano, Ghassan N. Fayad, Laurence Fayadat-Dilman, Symon Gathiaka, Heiko Greb, Brian Hall, Mas Handa, Mark Hsieh, Esther Kofman, Heping Lin, J. Richard Miller, Nhung Nguyen, Jennifer O’Neil, Hussam Shaheen, Eric Sterner, Corey Strickland, Angie Sun, Shane Taremi, Giovanna Scapin
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/15828ecf3c6a4e49a73581c4631d3a3d
Autor:
Marc Bailly, Carl Mieczkowski, Veronica Juan, Essam Metwally, Daniela Tomazela, Jeanne Baker, Makiko Uchida, Ester Kofman, Fahimeh Raoufi, Soha Motlagh, Yao Yu, Jihea Park, Smita Raghava, John Welsh, Michael Rauscher, Gopalan Raghunathan, Mark Hsieh, Yi-Ling Chen, Hang Thu Nguyen, Nhung Nguyen, Dan Cipriano, Laurence Fayadat-Dilman
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Monoclonal antibodies play an increasingly important role for the development of new drugs across multiple therapy areas. The term ‘developability’ encompasses the feasibility of molecules to successfully progress from discovery to development vi
Externí odkaz:
https://doaj.org/article/adb0a7cc163a47868054a9dee9dd053c
Autor:
Carl Mieczkowski, Alan Cheng, Thierry Fischmann, Mark Hsieh, Jeanne Baker, Makiko Uchida, Gopalan Raghunathan, Corey Strickland, Laurence Fayadat-Dilman
Publikováno v:
Antibodies, Vol 10, Iss 1, p 8 (2021)
Reversible antibody self-association, while having major developability and therapeutic implications, is not fully understood or readily predictable and correctable. For a strongly self-associating humanized mAb variant, resulting in unacceptable vis
Externí odkaz:
https://doaj.org/article/73b2cc3971324cedaf93982b4037c83f
Autor:
Carl Mieczkowski, Soheila Bahmanjah, Yao Yu, Jeanne Baker, Gopalan Raghunathan, Daniela Tomazela, Mark Hsieh, Mark McCoy, Corey Strickland, Laurence Fayadat-Dilman
Publikováno v:
Antibodies, Vol 9, Iss 4, p 66 (2020)
We report the novel crystal structure and characterization of symmetrical, homodimeric humanized heavy-chain-only antibodies or dimers (HC2s). HC2s were found to be significantly coexpressed and secreted along with mAbs from transient CHO HC/LC cotra
Externí odkaz:
https://doaj.org/article/1e33758d71ef4c78a8ebb00f37191035
Autor:
Laurence Fayadat-Dilman, Christine Andrews, Gulesi Ayanoglu, Liming Liu, Robert A. Kastelein, Aarron T. Willingham, Sabine Le Saux, Svetlana Sadekova, Dan Malashock, Hans van Eenennaam, Sophie Li, Ying Yu, Soonmo Peter Kang, Beth Hutchins, Andrea van Elsas, John Dulos, Rene De Waal Malefyt, Julie Lee, Frederique M. Poulet, Gregory J. Carven, Constance Cullen, Gary C. Starling, Mark Hsieh, Danuta J. Herzyk, Michel Streuli, Mark A. McCoy, George Soder
Publikováno v:
Molecular Cancer Therapeutics. 19:1298-1307
The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint, which may be engaged by cells in the tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®, MK-3475) is a potent and highly sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44ee4cad68943c640dee7d7ddd1ef5be
https://doi.org/10.1158/1535-7163.mct-19-0774
https://doi.org/10.1158/1535-7163.mct-19-0774
Autor:
Laurence Fayadat-Dilman, Jennifer O'Neil, Hussam Hisham Shaheen, Ghassan N. Fayad, Heping Lin, S. Shane Taremi, Giovanna Scapin, Corey Strickland, Heiko Greb, Nhung Nguyen, Symon Gathiaka, Mas Handa, Daniel Cipriano, Rachel L. Palte, Brian Hall, Eric Sterner, Veronica Juan, Esther Kofman, Xun Chen, Kalyan Chakravarthy, Yacob Gomez-Llorente, Mark Hsieh, J. Richard Miller, Angie Sun, Marc Andre Bailly
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Human Arginase 1 (hArg1) is a metalloenzyme that catalyzes the hydrolysis of l-arginine to l-ornithine and urea, and modulates T-cell-mediated immune response. Arginase-targeted therapies have been pursued across several disease areas including immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9236021a6a0eb417fbe5a119ad6b9d7a
https://doi.org/10.1038/s42003-021-02444-z
https://doi.org/10.1038/s42003-021-02444-z
Autor:
Symon Gathiaka, Mark Hsieh, Marc Andre Bailly, Brian Hall, Angie Sun, S. Shane Taremi, Veronica Juan, Xun Chen, J. Richard Miller, Mas Handa, Ghassan N. Fayad, Esther Kofman, Laurence Fayadat-Dilman, Jennifer O'Neil, Eric Sterner, Hussam Hisham Shaheen, Corey Strickland, Heping Lin, Kalyan Chakravarthy, Yacob Gomez-Llorente, Rachel L. Palte, Daniel Cipriano, Heiko Greb, Giovanna Scapin, Nhung Nguyen
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27a42145a850786d9d30f9a9345124f
https://doaj.org/article/15828ecf3c6a4e49a73581c4631d3a3d
https://doaj.org/article/15828ecf3c6a4e49a73581c4631d3a3d
Autor:
Mark Hsieh, J. Richard Miller, Brian Hall, Symon Gathiaka, Esther Kofman, Laurence Fayadat-Dilman, Veronica Juan, Yacob Gomez-Llorente, Rachel L. Palte, Mas Handa, S. Shane Taremi, Giovanna Scapin, Marc Andre Bailly
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 77:a67-a67
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ba84b6363d894afa48488f830a0fe4c
https://doi.org/10.1107/s0108767321099323
https://doi.org/10.1107/s0108767321099323
Autor:
Beth, Hutchins, Gary C, Starling, Mark A, McCoy, Danuta, Herzyk, Frederique M, Poulet, John, Dulos, Liming, Liu, Soonmo Peter, Kang, Laurence, Fayadat-Dilman, Mark, Hsieh, Christine L, Andrews, Gulesi, Ayanoglu, Constance, Cullen, Rene de Waal, Malefyt, Robert A, Kastelein, Sabine Le, Saux, Julie, Lee, Sophie, Li, Dan, Malashock, Svetlana, Sadekova, George, Soder, Hans, van Eenennaam, Aarron, Willingham, Ying, Yu, Michel, Streuli, Gregory J, Carven, Andrea, van Elsas
Publikováno v:
Molecular cancer therapeutics. 19(6)
The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint, which may be engaged by cells in the tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®, MK-3475) is a potent and highly sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::10d0b6eca5fefc531e03f4842302e6d9
https://pubmed.ncbi.nlm.nih.gov/32229606
https://pubmed.ncbi.nlm.nih.gov/32229606