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Relationship between anti-fungal effects and lung exposure of PC945, a novel inhaled antifungal agent, in Aspergillus fumigatus infected mice: Pulmonary PK-PD analysis of anti-fungal PC945

Autor: Kazuhiro, Ito, Yasuo, Kizawa, Genki, Kimura, Yuki, Nishimoto, Leah, Daly, Ian, Knowles, Mark, Hows, John, Ayrton, Pete, Strong

Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 163

PC945 is a novel antifungal agent, optimised for inhaled treatment. In this study, the relationship between antifungal effects of PC945 and its exposure in the lungs was investigated in Aspergillus fumigatus intranasally infected, temporarily neutrop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a253171a4c841a18ad8cdcad73747429
https://pubmed.ncbi.nlm.nih.gov/34015430

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Late therapeutic intervention with a respiratory syncytial virus L-protein polymerase inhibitor, PC786, on respiratory syncytial virus infection in human airway epithelium

Autor: Samuel Constant, Mark Hows, Garth Rapeport, Kazuhiro Ito, Lindsey Cass, Leah Daly, Song Huang, Amanda Davis, Daniel W. Brookes, Pete Strong, Ian D Knowles, John Ayrton, Matthew Coates, Heather Allen

Publikováno v: British Journal of Pharmacology. 175:2520-2534

Background and purpose Effective anti-respiratory syncytial virus (RSV) agents are still not available for clinical use. Current major targets are virus surface proteins, such as a fusion protein involved in viral entry, but agents effective after RS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5249d1be051e207dbc7e6f5ffbf5a2b0
https://doi.org/10.1111/bph.14221

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Relationship between anti-fungal effects and lung exposure of PC945, a novel inhaled antifungal agent, in Aspergillus fumigatus infected mice

Autor: Leah Daly, Pete Strong, Yuki Nishimoto, Mark Hows, Yasuo Kizawa, Ian D Knowles, Kazuhiro Ito, Genki Kimura, John Ayrton

Publikováno v: European Journal of Pharmaceutical Sciences. 163:105878

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b01bb50fdc17ff1dfabf136bb40d4ec
https://doi.org/10.1016/j.ejps.2021.105878

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Late therapeutic intervention with a respiratory syncytial virus L-protein polymerase inhibitor, PC786, on respiratory syncytial virus infection in human airway epithelium

Autor: Daniel W, Brookes, Matthew, Coates, Heather, Allen, Leah, Daly, Samuel, Constant, Song, Huang, Mark, Hows, Amanda, Davis, Lindsey, Cass, John, Ayrton, Ian, Knowles, Pete, Strong, Garth, Rapeport, Kazuhiro, Ito

Publikováno v: British Journal of Pharmacology

Background and Purpose Effective anti‐respiratory syncytial virus (RSV) agents are still not available for clinical use. Current major targets are virus surface proteins, such as a fusion protein involved in viral entry, but agents effective after

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bff4c91bc743ee67d50356869dc87bc8
https://pubmed.ncbi.nlm.nih.gov/29579332

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LATE-BREAKING ABSTRACT: Effects of a single treatment with PC786, a novel inhibitor of respiratory syncytial virus replication, on viral load and biomarkers in fully differentiated human bronchial epithelial cells

Autor: Pete Strong, Daniel W. Brookes, Kazuhiro Ito, Heather Allen, Matthew Coates, Mark Hows, Amanda Davis, Garth Rapeport, John Ayrton

Publikováno v: 10.1 Respiratory Infections.

Addition of RSV A2 to fully-differentiated air-liquid interface cultured human bronchial epithelial cells resulted in a robust infection which generated amplified viral titres and measurable pro-inflammatory biomarkers. The novel first-in-class anti-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf7db340a9f82a25f80f526f5bbe07c6
https://doi.org/10.1183/13993003.congress-2016.oa4989

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Dose dependent penetration of tulathromycin in pig tonsils

Autor: Guillermo Cano, Mark Hows, Regina Janes, Alberto Morillo, Lorenzo Fraile

Publikováno v: ResearcherID
Recercat. Dipósit de la Recerca de Catalunya
instname
Repositorio Abierto de la UdL
Universitad de Lleida

Background and Objectives: There is a paucity of information about the penetration of antimicrobials in tonsils from pigs with the final goal to eradicate bacteria from this tissue where different microorganisms can survive for long periods of time.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a290e0d7fdd41edd104845491e0c681
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CABI&KeyUT=CABI:20153148196&KeyUID=CABI:20153148196

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