Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Mark, Gosink"'
Autor:
Elias M. Oziolor, Steven W. Kumpf, Jessie Qian, Mark Gosink, Mark Sheehan, David M. Rubitski, Leah Newman, Laurence O. Whiteley, Thomas A. Lanz
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 395-405 (2023)
Many current gene therapy targets use recombinant adeno-associated virus (AAV). The majority of delivered AAV therapeutics persist as episomes, separate from host DNA, yet some viral DNA can integrate into host DNA in different proportions and at gen
Externí odkaz:
https://doaj.org/article/408d92ef4a474a9ab96737ca95b99093
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Formalin fixation of biological specimens damages nucleic acids and limits their use in genomic analyses. Previously, we showed that RNA isolation with an organocatalyst (2-amino-5-methylphenyl phosphonic acid, used to speed up reversal of f
Externí odkaz:
https://doaj.org/article/c82f8591c92b4bb0a366519a2cd4a31f
Autor:
Besma Benredjem, Jonathan Gallion, Dennis Pelletier, Paul Dallaire, Johanie Charbonneau, Darren Cawkill, Karim Nagi, Mark Gosink, Viktoryia Lukasheva, Stephen Jenkinson, Yong Ren, Christopher Somps, Brigitte Murat, Emma Van Der Westhuizen, Christian Le Gouill, Olivier Lichtarge, Anne Schmidt, Michel Bouvier, Graciela Pineyro
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Identifying ligands which activate the specific effectors driving particular in vivo drug effects remains challenging. Here, the authors apply unsupervised clustering of pharmacodynamic parameters to classify GPCR ligands into different categories wi
Externí odkaz:
https://doaj.org/article/c0db3f1cf110426bbd5f35d40fd3681b
Autor:
Besma Benredjem, Jonathan Gallion, Dennis Pelletier, Paul Dallaire, Johanie Charbonneau, Darren Cawkill, Karim Nagi, Mark Gosink, Viktoryia Lukasheva, Stephen Jenkinson, Yong Ren, Christopher Somps, Brigitte Murat, Emma Van Der Westhuizen, Christian Le Gouill, Olivier Lichtarge, Anne Schmidt, Michel Bouvier, Graciela Pineyro
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/1f09235de66f4fc295108bc582f6d396
Autor:
Timothy M Coskran, Zhijie Jiang, James E Klaunig, Dixie L Mager, Leslie Obert, Andrew Robertson, Nicholas Tsinoremas, Zemin Wang, Mark Gosink
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176768 (2017)
A number of chemical compounds have been shown to induce liver tumors in mice but not in other species. While several mechanisms for this species-specific tumorigenicity have been proposed, no definitive mechanism has been established. We examined th
Externí odkaz:
https://doaj.org/article/77f70d26f5cc49d79b7be814cb53e00a
Autor:
Julian Krauskopf, Theo M de Kok, Shelli J Schomaker, Mark Gosink, Deborah A Burt, Patricia Chandler, Roscoe L Warner, Kent J Johnson, Florian Caiment, Jos C Kleinjans, Jiri Aubrecht
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177928 (2017)
MicroRNAs (miRNAs) released into the peripheral circulation upon cellular injury have shown a promise as a new class of tissue-specific biomarkers. We were first to demonstrate that next-generation sequencing analysis of serum from human subjects wit
Externí odkaz:
https://doaj.org/article/6a3a8dc8c7d94bc4b5875f5669f6032b
Publikováno v:
Drug discovery today. 27(11)
There are many machine learning models that use molecular fingerprints of drugs to predict side effects. Characterizing their skill is necessary for understanding their usefulness in pharmaceutical development. Here, we analyze a statistical control
Publikováno v:
Scientific reports. 12(1)
Formalin fixation of biological specimens damages nucleic acids and limits their use in genomic analyses. Previously, we showed that RNA isolation with an organocatalyst (2-amino-5-methylphenyl phosphonic acid, used to speed up reversal of formalin-i
Autor:
Stephen Jenkinson, Jonathan Gallion, Darren Cawkill, Brigitte Murat, Olivier Lichtarge, Yong Ren, Michel Bouvier, Karim Nagi, Emma T van der Westhuizen, Christian Le Gouill, Besma Benredjem, Viktoryia Lukasheva, Johanie Charbonneau, Paul Dallaire, Mark Gosink, Anne W. Schmidt, Christopher Somps, Dennis J. Pelletier, Graciela Piñeyro
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Signaling diversity of G protein-coupled (GPCR) ligands provides novel opportunities to develop more effective, better-tolerated therapeutics. Taking advantage of these opportunities requires identifying which effectors should be specifically activat
Autor:
Mark Gosink, Shelli J. Schomaker, Kent J. Johnson, Florian Caiment, Julian Krauskopf, Jos C. S. Kleinjans, Jiri Aubrecht, Roscoe L. Warner
Publikováno v:
American journal of case reports, 21:919289. International Scientific Literature, Inc
The American Journal of Case Reports
The American Journal of Case Reports
Patient: Female, 44-year-old Final Diagnosis: Acute liver failure Symptoms: APAP overdose Medication: Acetaminophen Clinical Procedure: — Specialty: Molecular Biology Objective: Unusual clinical course Background: Acetaminophen overdose is the most