Zobrazeno 1 - 10
of 807
pro vyhledávání: '"Mark, Gerstein"'
Autor:
Xiaona Lu, Pengyu Ni, Paola Suarez-Meade, Yu Ma, Emily Niemitz Forrest, Guilin Wang, Yi Wang, Alfredo Quiñones-Hinojosa, Mark Gerstein, Yong-hui Jiang
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114376- (2024)
Summary: Precision of transcription is critical because transcriptional dysregulation is disease causing. Traditional methods of transcriptional profiling are inadequate to elucidate the full spectrum of the transcriptome, particularly for longer and
Externí odkaz:
https://doaj.org/article/fc95a257f22349b9bb5b87d26085c896
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract For the COVID-19 pandemic, viral transmission has been documented in many historical and geographical contexts. Nevertheless, few studies have explicitly modeled the spatiotemporal flow based on genetic sequences, to develop mitigation strat
Externí odkaz:
https://doaj.org/article/0a68916765484e4a875126b56157bd78
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Cancer genomics tailors diagnosis and treatment based on an individual’s genetic information and is the crux of precision medicine. However, analysis and maintenance of high volume of genetic mutation data to build a machine learning (ML)
Externí odkaz:
https://doaj.org/article/feef21279e8c431287ba803591ee2979
Autor:
Shaoke Lou, Mingjun Yang, Tianxiao Li, Weihao Zhao, Hannah Cevasco, Yucheng T Yang, Mark Gerstein
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 7, p e1011222 (2023)
The COVID-19 pandemic caused by the SARS-CoV-2 virus has resulted in millions of deaths worldwide. The disease presents with various manifestations that can vary in severity and long-term outcomes. Previous efforts have contributed to the development
Externí odkaz:
https://doaj.org/article/d695763806e0400b833124b01159cec7
Autor:
Ioannis A. Vathiotis, Leonidas Salichos, Sandra Martinez-Morilla, Niki Gavrielatou, Thazin Nwe Aung, Saba Shafi, Pok Fai Wong, Shlomit Jessel, Harriet M. Kluger, Konstantinos N. Syrigos, Sarah Warren, Mark Gerstein, David L. Rimm
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-8 (2022)
Abstract Treatment with immune checkpoint inhibitors has altered the course of malignant melanoma, with approximately half of the patients with advanced disease surviving for more than 5 years after diagnosis. Currently, there are no biomarker method
Externí odkaz:
https://doaj.org/article/956f4e8b0c1545fa97bfbb01c858e7bd
Autor:
Shuang Liu, Hyejung Won, Declan Clarke, Nana Matoba, Saniya Khullar, Yudi Mu, Daifeng Wang, Mark Gerstein
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-15 (2022)
Abstract Background Neuropsychiatric disorders afflict a large portion of the global population and constitute a significant source of disability worldwide. Although Genome-wide Association Studies (GWAS) have identified many disorder-associated vari
Externí odkaz:
https://doaj.org/article/f27667976e18464f80dc9bd617221320
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
In the era of single-cell sequencing, there is a growing need to extract insights from data with clustering methods. Here, inspired by forest fire dynamics, the authors devise an algorithm that can cluster single-cell data with minimal prior assumpti
Externí odkaz:
https://doaj.org/article/b57f40c651f447d48f8acfeb8201e8df
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-22 (2022)
Abstract There are major efforts underway to make genome sequencing a routine part of clinical practice. A critical barrier to these is achieving practical solutions for data ownership and integrity. Blockchain provides solutions to these challenges
Externí odkaz:
https://doaj.org/article/fe4ce4c6c7c44a48b2e50498949aceb3
Autor:
Che Yu Lee, Yuhang Chen, Ziheng Duan, Min Xu, Matthew J Girgenti, Ke Xu, Mark Gerstein, Jing Zhang
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 10, p e1010636 (2022)
Early and accurate detection of viruses in clinical and environmental samples is essential for effective public healthcare, treatment, and therapeutics. While PCR detects potential pathogens with high sensitivity, it is difficult to scale and require
Externí odkaz:
https://doaj.org/article/7bd62ffc0d0f47768fbe613db5244c5b
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-9 (2021)
Abstract With the recent increase in RNA sequencing efforts using large cohorts of individuals, surveying allele-specific gene expression is becoming increasingly frequent. Here, we report that, despite not containing explicit variant information, a
Externí odkaz:
https://doaj.org/article/81a41c5bba57448eb9f65fcf149e6984