Zobrazeno 1 - 10
of 1 286
pro vyhledávání: '"Mark, FitzGerald"'
Autor:
Qi Hao, Manoj K. Rathinaswamy, Kelly L. Klinge, Matthew Bratkowski, Amirhossein Mafi, Christina K. Baumgartner, Keith M. Hamel, Gesine K. Veits, Rinku Jain, Claudio Catalano, Mark Fitzgerald, Alexander W. Hird, Eunice Park, Harit U. Vora, James A. Henderson, Kenton Longenecker, Charles W. Hutchins, Wei Qiu, Giovanna Scapin, Qi Sun, Vincent S. Stoll, Chaohong Sun, Ping Li, Dan Eaton, David Stokoe, Stewart L. Fisher, Christopher G. Nasveschuk, Marcia Paddock, Michael E. Kort
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract PTPN2 (protein tyrosine phosphatase non-receptor type 2, or TC-PTP) and PTPN1 are attractive immuno-oncology targets, with the deletion of Ptpn1 and Ptpn2 improving response to immunotherapy in disease models. Targeted protein degradation ha
Externí odkaz:
https://doaj.org/article/1f2680b79836478cba894b08e1a585a6
Autor:
Lilia Falkenstern, Victoria Georgi, Stefanie Bunse, Volker Badock, Manfred Husemann, Ulrike Roehn, Timo Stellfeld, Mark Fitzgerald, Steven Ferrara, Detlef Stöckigt, Carlo Stresemann, Ingo V. Hartung, Amaury Fernández-Montalván
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-21 (2024)
Abstract The market approval of Tazemetostat (TAZVERIK) for the treatment of follicular lymphoma and epithelioid sarcoma has established “enhancer of zeste homolog 2” (EZH2) as therapeutic target in oncology. Despite their structural similarities
Externí odkaz:
https://doaj.org/article/86f7032f806147479748eda7c74b8341
Autor:
Qingsong Zhou, Louis Raymond Francis Rose, Peter Ebeling, Matthias Russ, Mark Fitzgerald, Wing Kong Chiu
Publikováno v:
Sensors, Vol 24, Iss 19, p 6453 (2024)
A simplified axisymmetric model of a transfemoral osseointegration implant was used to investigate the influence of the contact condition at the bone–implant interface on the vibrational response. The experimental setup allowed the degree of implan
Externí odkaz:
https://doaj.org/article/44586cc18f384ff88b7b06cf040b028a
Autor:
Michael Noonan, Cecil Johnny, Yen Kim, Gerard O'Reilly, Chris Groombridge, Joseph Mathew, Mark Fitzgerald
Publikováno v:
Health Sciences Review, Vol 11, Iss , Pp 100164- (2024)
Injury remains a significant global health concern, with early major haemorrhage (MH) being a leading cause of preventable death. However, the absence of a standardised definition for MH hinders research comparability and optimal clinical decision-ma
Externí odkaz:
https://doaj.org/article/88d51246bf3c4c679cd3383bcb039dbd
Autor:
Warren Clements, Mark Fitzgerald, S. Murthy Chennapragada, Joseph Mathew, Christopher Groombridge, Ee Jun Ban, Matthew W. Lukies
Publikováno v:
CVIR Endovascular, Vol 6, Iss 1, Pp 1-9 (2023)
Abstract Background Splenic artery embolisation (SAE) has become a vital strategy in the modern landscape of multidisciplinary trauma care, improving splenic salvage rates in patients with high-grade injury. However, due to a lack of prospective data
Externí odkaz:
https://doaj.org/article/00a1e95f9f564ec1af87d083b4a2bee1
Autor:
Dries Helsloot, Mark Fitzgerald, Rolf Lefering, Sandra Verelst, Carlo Missant, the TraumaRegister DGU
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-12 (2023)
Abstract Background To which extent trauma- induced disturbances in ionized calcium (iCa2+) levels have a linear relationship with adverse outcomes remains controversial. The goal of this study was to determine the association between the distributio
Externí odkaz:
https://doaj.org/article/0ed0cc6f7dd3495eb2d8829dd13127c5
Autor:
Mark Fitzgerald, Biswadev Mitra, Joseph Mathew, Bivekjeet Singh, Cara Stewart, Christine Koolstra, Simon Hendel
Publikováno v:
Trauma Surgery & Acute Care Open, Vol 9, Iss 1 (2024)
Introduction Transfusion of blood components is vital for the resuscitation of injured patients in hemorrhagic shock. Delays in initiating transfusion have been associated with harm, as has excess transfusion. The aim of this study was to evaluate va
Externí odkaz:
https://doaj.org/article/dc8a0889ab0c46a5a49a64d08258e97f
Autor:
Wenjia Chen, Helen K. Reddel, J Mark FitzGerald, Richard Beasley, Christer Janson, Mohsen Sadatsafavi
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-9 (2023)
Abstract Background Individualized prediction of treatment response may improve the value proposition of advanced treatment options in severe asthma. This study aimed to investigate the combined capacity of patient characteristics in predicting treat
Externí odkaz:
https://doaj.org/article/ecb1e09079e7415193bf54008146436a
Autor:
Karen Rideout, J Mark FitzGerald, Christopher Carlsten, Alison Hoens, Nardia Strydom, Dan Smith, Aneisha Collins-Fairclough, Phalgun Joshi, Jeremiah Philips, Tony Lanier, Santa Chow, Chris Rauscher
Publikováno v:
BMJ Open Quality, Vol 12, Iss 4 (2023)
Background The healthcare experiences of patients hold valuable insights for improving the quality of services related to their well-being. We therefore invited and explored the perspectives of patients living with asthma and chronic obstructive pulm
Externí odkaz:
https://doaj.org/article/77bca35a37cc42ceb390b6cbf79bba53