Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Mark, Farrant"'
Enhanced functional detection of synaptic calcium-permeable AMPA receptors using intracellular NASPM
Autor:
Ian Coombs, Cécile Bats, Craig A Sexton, Dorota Studniarczyk, Stuart G Cull-Candy, Mark Farrant
Publikováno v:
eLife, Vol 12 (2023)
Calcium-permeable AMPA-type glutamate receptors (CP-AMPARs) contribute to many forms of synaptic plasticity and pathology. They can be distinguished from GluA2-containing calcium-impermeable AMPARs by the inward rectification of their currents, which
Externí odkaz:
https://doaj.org/article/49f9a89f7bef4f0c803556abfb71db58
Autor:
Lorenza Magno, Zeinab Asgarian, Valentina Pendolino, Theodora Velona, Albert Mackintosh, Flora Lee, Agata Stryjewska, Celine Zimmer, François Guillemot, Mark Farrant, Beverley Clark, Nicoletta Kessaris
Publikováno v:
Cell Reports, Vol 35, Iss 11, Pp 109249- (2021)
Summary: Cortical GABAergic interneurons are generated in large numbers in the ganglionic eminences and migrate into the cerebral cortex during embryogenesis. At early postnatal stages, during neuronal circuit maturation, autonomous and activity-depe
Externí odkaz:
https://doaj.org/article/e2d0408bf0594de0a7200913d8bf8c4f
Autor:
Ian D. Coombs, David Soto, Thomas P. McGee, Matthew G. Gold, Mark Farrant, Stuart G. Cull-Candy
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
AMPA-type glutamate receptors, which mediate fast excitatory signaling throughout the brain, exhibit profound desensitization, causing a progressive current decline in the continued presence of agonist. Here authors show that homomeric Q/R edited AMP
Externí odkaz:
https://doaj.org/article/a50e120ec8be4c268b59eed05b410716
Autor:
Elizabeth C. Davenport, Valentina Pendolino, Georgina Kontou, Thomas P. McGee, David F. Sheehan, Guillermo López-Doménech, Mark Farrant, Josef T. Kittler
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 70-83 (2017)
Inhibitory synaptic transmission requires the targeting and stabilization of GABAA receptors (GABAARs) at synapses. The mechanisms responsible remain poorly understood, and roles for transmembrane accessory proteins have not been established. Using m
Externí odkaz:
https://doaj.org/article/6314c57e64fa4530b58aaa74b48f5c0f
Publikováno v:
Cell Reports, Vol 20, Iss 5, Pp 1123-1135 (2017)
Summary: Fast excitatory transmission in the CNS is mediated mainly by AMPA-type glutamate receptors (AMPARs) associated with transmembrane AMPAR regulatory proteins (TARPs). At the high glutamate concentrations typically seen during synaptic transmi
Externí odkaz:
https://doaj.org/article/1b016edfb63f49ab918fe04dff457cd5
Autor:
Amani Al-Adsani, Zoë D Burke, Daniel Eberhard, Katherine L Lawrence, Chia-Ning Shen, Anil K Rustgi, Hiroshi Sakaue, J Mark Farrant, David Tosh
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219419 (2019)
[This corrects the article DOI: 10.1371/journal.pone.0013650.].
Externí odkaz:
https://doaj.org/article/edcc634b4f6541bd982ad2a9cd4c8508
Publikováno v:
Molecular Pharmacology. 101:343-356
AMPA-type gultamate receptors (AMPARs) mediate excitatory signaling in the brain and are therapeutic targets for the treatment of diverse neurological disorders. The receptors interact with a variety of auxiliary subunits, including the transmembrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48668a95fe9b0aac76c01d66d93f78f2
https://doi.org/10.1124/molpharm.121.000473
https://doi.org/10.1124/molpharm.121.000473
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 10 (2018)
Calcium-permeable (CP) AMPA-type glutamate receptors (AMPARs) are known to mediate synaptic plasticity in several different interneuron (IN) types. Recent evidence suggests that CP-AMPARs are synapse-specifically expressed at excitatory connections o
Externí odkaz:
https://doaj.org/article/d0b55e831aa642299b06e3015522ee3a
Autor:
Ian D. Coombs, Julie Ziobro, Volodymyr Krotov, Taryn‐Leigh Surtees, Stuart G. Cull‐Candy, Mark Farrant
Publikováno v:
EpilepsiaREFERENCES. 63(12)
α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptors (AMPARs) are ligand-gated cationic channels formed from combinations of GluA1-4 subunits. Pathogenic variants of GRIA1-4 have been described in patients with developmental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8bebea3fe3f57404473b91f0434ba6d
https://pubmed.ncbi.nlm.nih.gov/36161652
https://pubmed.ncbi.nlm.nih.gov/36161652