Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Mark, Donnelly"'
Autor:
Xiaomei Chen, Henrik B. Nyberg, Mark Donnelly, Liang Zhao, Lanyan Fang, Mats O. Karlsson, Andrew C. Hooker
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 10, Pp 1734-1747 (2024)
Abstract By applying nonlinear mixed‐effect (NLME) models, model‐integrated evidence (MIE) approaches are able to analyze bioequivalence (BE) data with pharmacokinetic end points that have sparse sampling, which is problematic for non‐compartme
Externí odkaz:
https://doaj.org/article/2e1329167ac44ce096430f86304bb58d
Autor:
Henrik Bjugård Nyberg, Xiaomei Chen, Mark Donnelly, Lanyan Fang, Liang Zhao, Mats O. Karlsson, Andrew C. Hooker
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 10, Pp 1748-1761 (2024)
Abstract Conventional approaches for establishing bioequivalence (BE) between test and reference formulations using non‐compartmental analysis (NCA) may demonstrate low power in pharmacokinetic (PK) studies with sparse sampling. In this case, model
Externí odkaz:
https://doaj.org/article/818524a9727b4db99705ea0d5a2a6947
Autor:
Miguel Ortiz-Barrios, Ian Cleland, Mark Donnelly, Muhammet Gul, Melih Yucesan, Genett Isabel Jiménez-Delgado, Chris Nugent, Stephany Madrid-Sierra
Publikováno v:
JMIR Rehabilitation and Assistive Technologies, Vol 11, Pp e57940-e57940 (2024)
Abstract BackgroundParkinson disease (PD) is reported to be among the most prevalent neurodegenerative diseases globally, presenting ongoing challenges and increasing burden on health care systems. In an effort to support patients with PD, their car
Externí odkaz:
https://doaj.org/article/2dd3916173e140b18b66da45244245a6
Autor:
Coralie Tardivon, Florence Loingeville, Mark Donnelly, Kairui Feng, Wanjie Sun, Guoying Sun, Stella Grosser, Liang Zhao, Lanyan Fang, France Mentré, Julie Bertrand
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 7, Pp 904-915 (2023)
Abstract In a traditional pharmacokinetic (PK) bioequivalence (BE) study, a two‐way crossover study is conducted, PK parameters (namely the area under the time‐concentration curve [AUC] and the maximal concentration [Cmax]) are obtained by noncom
Externí odkaz:
https://doaj.org/article/139a16dd116f45258f338771f7006e43
Autor:
Angela Hassiotis, Mark Donnelly, Laurence Taggart, Emma Pagnamenta, Naomi Leafe, Jill Titterington
Publikováno v:
BMJ Open, Vol 14, Iss 1 (2024)
Introduction Speech and language therapists (SLTs) worldwide report challenges with providing recommended, evidence-based intervention intensity for children with speech sound disorder (SSD). Challenges such as service constraints and/or family conte
Externí odkaz:
https://doaj.org/article/6f1f7298c2814376909dad1e0e2ff59c
Mad Dogs and Englishness connects English popular music with questions about English national identities, featuring essays that range across Bowie and Burial, PJ Harvey, Bishi and Tricky. The later years of the 20th century saw a resurgence of intere
Publikováno v:
JMIR Formative Research, Vol 6, Iss 8, p e37994 (2022)
BackgroundPeople with autism spectrum disorder (ASD) frequently experience high levels of anxiety. Despite this, many clinical settings do not provide specialist ASD mental health services, and demand for professional support frequently outstrips sup
Externí odkaz:
https://doaj.org/article/282df80c43694c08a1273544754fd7b8
Publikováno v:
Algorithms, Vol 15, Iss 5, p 174 (2022)
Concept drift, which refers to changes in the underlying process structure or customer behaviour over time, is inevitable in business processes, causing challenges in ensuring that the learned model is a proper representation of the new data. Due to
Externí odkaz:
https://doaj.org/article/1e8c07f18609427f9a0f44edc23673e5
Autor:
Ammar Al-Rifaie, Mohammed Gariballa, Alhassan Ghodeif, Stephen Hodge, Mo Thoufeeq, Mark Donnelly
Publikováno v:
Endoscopy International Open, Vol 09, Iss 01, Pp E102-E109 (2021)
Background and study aims Colonoscopy is physically demanding for endoscopists and patients. Repetitive movements during colonoscopy can lead to overuse injuries. We aimed to explore the prevalence and range of colonoscopy-related musculoskeletal inj
Externí odkaz:
https://doaj.org/article/820b989c41f84745834cecef284f0335
Autor:
Jieon Lee, Kairui Feng, Denise S. Conti, Ross Walenga, Michael Wientjes, Hezhen Wang, Bryan Newman, Liangfeng Han, Sneha Dhapare, Elizabeth Bielski, Andrew Babiskin, Fang Wu, Mark Donnelly, Myong‐Jin Kim, Wenlei Jiang, Markham C. Luke, Lanyan Fang, Liang Zhao
Publikováno v:
Clinical Pharmacology & Therapeutics. 112:982-989
Herein, we present the US Food and Drug Administration (FDA) Office of Research and Standards' current thinking, challenges, and opportunities for comparative clinical endpoint bioequivalence (BE) studies of orally inhaled drug products (OIDPs). Give
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c925cfdc9f41d56c03ffa53e6c4684ee
https://doi.org/10.1002/cpt.2553
https://doi.org/10.1002/cpt.2553