Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Mark, Carrington"'
Publikováno v:
eLife, Vol 12 (2024)
African trypanosomes replicate within infected mammals where they are exposed to the complement system. This system centres around complement C3, which is present in a soluble form in serum but becomes covalently deposited onto the surfaces of pathog
Externí odkaz:
https://doaj.org/article/6730aab5a1254415b53e756fbdf4bda6
Autor:
Amanda T. S. Albanaz, Mark Carrington, Alexander O. Frolov, Anna I. Ganyukova, Evgeny S. Gerasimov, Alexei Y. Kostygov, Julius Lukeš, Marina N. Malysheva, Jan Votýpka, Alexandra Zakharova, Kristína Záhonová, Sara L. Zimmer, Vyacheslav Yurchenko, Anzhelika Butenko
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract Background Protists of the family Trypanosomatidae (phylum Euglenozoa) have gained notoriety as parasites affecting humans, domestic animals, and agricultural plants. However, the true extent of the group's diversity spreads far beyond the m
Externí odkaz:
https://doaj.org/article/1ccbe175e908488286a6ce1d72afa3ae
Autor:
Olivia J. S. Macleod, Alexander D. Cook, Helena Webb, Mandy Crow, Roisin Burns, Maria Redpath, Stefanie Seisenberger, Camilla E. Trevor, Lori Peacock, Angela Schwede, Nicola Kimblin, Amanda F. Francisco, Julia Pepperl, Steve Rust, Paul Voorheis, Wendy Gibson, Martin C. Taylor, Matthew K. Higgins, Mark Carrington
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Trypanosomes evade the immune response through antigenic variation of a surface coat containing variant surface glycoproteins (VSG). They also express invariant surface glycoproteins (ISGs), which are less well understood. Here, Macleod et al. show t
Externí odkaz:
https://doaj.org/article/707129a04c2c4ac7890d6e8e9479ca7e
Autor:
Andrea Martos-Esteban, Olivia J. S. Macleod, Isabella Maudlin, Konstantinos Kalogeropoulos, Jonas A. Jürgensen, Mark Carrington, Andreas H. Laustsen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract African trypanosomes, such as Trypanosoma brucei, are flagellated protozoa which proliferate in mammals and cause a variety of diseases in people and animals. In a mammalian host, the external face of the African trypanosome plasma membrane
Externí odkaz:
https://doaj.org/article/52bcd530f9fe4bbc8ab500c9fce4cd8f
Autor:
Maria J. R. Bezerra, Danielle M. N. Moura, Eden R. Freire, Fabiola B. Holetz, Christian R. S. Reis, Tallyta T. S. Monteiro, Adriana R. S. Pinto, Ning Zhang, Antonio M. Rezende, Antonio Pereira-Neves, Regina C. B. Q. Figueiredo, Christine Clayton, Mark C. Field, Mark Carrington, Osvaldo P. de Melo Neto
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Gene expression in pathogenic protozoans of the family Trypanosomatidae has several novel features, including multiple eIF4F-like complexes involved in protein synthesis. The eukaryotic eIF4F complex, formed mainly by eIF4E and eIF4G subunits, is res
Externí odkaz:
https://doaj.org/article/209fd9a580714eabae65717513a48ea1
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Lori Peacock et al. report the sequence of meiosis in Trypanosoma brucei cells from the salivary glands of tsetse flies using image analyses and expression of the cell fusion protein HAP2. From the recovered cell types and expression of HAP2 in meiot
Externí odkaz:
https://doaj.org/article/5ca667faa8114679b2ec5bf8a76d9380
Autor:
Jennifer Afua Ofori, Soale Majeed Bakari, Saikou Bah, Michael Kojo Kolugu, George Kwame Aning, Gordon Akanzuwine Awandare, Mark Carrington, Theresa Manful Gwira
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 4, p e0010300 (2022)
BackgroundAnimal African Trypanosomiasis (AAT) is one of the most economically important diseases affecting livestock productivity in sub-Saharan Africa. The disease is caused by a broad range of Trypanosoma spp., infecting both wild and domesticated
Externí odkaz:
https://doaj.org/article/18ad54a522a145db99efb31d9d386021
Autor:
Olivia J. S. Macleod, Jean-Mathieu Bart, Paula MacGregor, Lori Peacock, Nicholas J. Savill, Svenja Hester, Sophie Ravel, Jack D. Sunter, Camilla Trevor, Steven Rust, Tristan J. Vaughan, Ralph Minter, Shabaz Mohammed, Wendy Gibson, Martin C. Taylor, Matthew K. Higgins, Mark Carrington
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
African trypanosome infections can persist for years, but immune evasion mechanisms are not fully understood. Here, Macleod et al. identify a trypanosome receptor for mammalian factor H, a negative regulator of the alternative complement pathway, tha
Externí odkaz:
https://doaj.org/article/26bfcfd0e9cc483dae71e8f47f88e8ec
Autor:
Joel L Bargul, Kevin O Kidambasi, Merid N Getahun, Jandouwe Villinger, Robert S Copeland, Jackson M Muema, Mark Carrington, Daniel K Masiga
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009671 (2021)
Anaplasmosis, caused by infection with bacteria of the genus Anaplasma, is an important veterinary and zoonotic disease. Transmission by ticks has been characterized but little is known about non-tick vectors of livestock anaplasmosis. This study inv
Externí odkaz:
https://doaj.org/article/945db58e7e5a4a03b4166c2933fca736
Autor:
ThankGod E. Ebenezer, Martin Zoltner, Alana Burrell, Anna Nenarokova, Anna M. G. Novák Vanclová, Binod Prasad, Petr Soukal, Carlos Santana-Molina, Ellis O’Neill, Nerissa N. Nankissoor, Nithya Vadakedath, Viktor Daiker, Samson Obado, Sara Silva-Pereira, Andrew P. Jackson, Damien P. Devos, Julius Lukeš, Michael Lebert, Sue Vaughan, Vladimίr Hampl, Mark Carrington, Michael L. Ginger, Joel B. Dacks, Steven Kelly, Mark C. Field
Publikováno v:
BMC Biology, Vol 17, Iss 1, Pp 1-23 (2019)
Abstract Background Photosynthetic euglenids are major contributors to fresh water ecosystems. Euglena gracilis in particular has noted metabolic flexibility, reflected by an ability to thrive in a range of harsh environments. E. gracilis has been a
Externí odkaz:
https://doaj.org/article/2868d305893e4aab965f7b5d0cb8e23c