Výsledky vyhledávání

Structural Basis for ( S)-3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu

Autor: Qi, Chen, Joseph D, Ho, Sheela, Ashok, Michelle C, Vargas, Jing, Wang, Shane, Atwell, Mark, Bures, Jeffery M, Schkeryantz, James A, Monn, Junliang, Hao

Publikováno v: Journal of medicinal chemistry. 61(22)

( S)-3,4-Dicarboxyphenylglycine (DCPG) was first reported in 2001 as a potent orthosteric agonist with high subtype selectivity for the mGlu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::abe467531ff4115e443495ba4bed0c79
https://pubmed.ncbi.nlm.nih.gov/30365309

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PS-073-Preclinical profile of HBV core protein inhibitor, ABI-H, a potent inhibitor of cccDNA generation in HBV infected cells

Autor: Mark Bures, Haydar Simon, Walker Michael, Lida Guo, Richard J. Colonno, Xuman Tang, Ran Yan, Li Leping, Qi Huang, Xiang Xu, Yi Zhou, Dawei Cai, Rai Roopa, Esteban Carabajal

Publikováno v: Journal of Hepatology. 70:e48

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::adf2efbbac14766fe910d0f7d0fabf79
https://doi.org/10.1016/s0618-8278(19)30085-4

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Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist

Publikováno v: Journal of medicinal chemistry. 58(18)

Identification of orthosteric mGlu(2/3) receptor agonists capable of discriminating between individual mGlu2 and mGlu3 subtypes has been highly challenging owing to the glutamate-site sequence homology between these proteins. Herein we detail the pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b3e08f0001b2fb8da6ecccee3a121fe3
https://pubmed.ncbi.nlm.nih.gov/26313429

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Synthesis and pharmacological characterization of C4-disubstituted analogs of 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: identification of a potent, selective metabotropic glutamate receptor agonist and determination of agonist-bound human mGlu2 and mGlu3 amino terminal domain structures

Publikováno v: Journal of medicinal chemistry. 58(4)

As part of our ongoing research to identify novel agents acting at metabotropic glutamate 2 (mGlu2) and 3 (mGlu3) receptors, we have previously reported the identification of the C4α-methyl analog of mGlu2/3 receptor agonist 1 (LY354740). This molec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::257cce6d5aa3ab6ae8072e84e32e8018
https://pubmed.ncbi.nlm.nih.gov/25602126

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Preclinical Characterization of Potent Core Protein Assembly Modulators for the Treatment of Chronic Hepatitis B

Publikováno v: Journal of Hepatology. 64:S584

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::abd7e018fcd61ec9813364f73557566c
https://doi.org/10.1016/s0168-8278(16)01072-2

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Akademický článek

Synthesis and Metabotropic Glutamate Receptor Activity of S-Oxidized Variants of (−)-4-Amino-2-thiabicyclo-3.1.0hexane-4,6-dicarboxylate: Identification of Potent, Selective, and Orally Bioavailable Agonists for mGlu2/3 Receptors.

Autor: James A. Monn, Steven M. Massey, Matthew J. Valli, Steven S. Henry, Gregory A. Stephenson, Mark Bures, Marc Hérin, John Catlow, Deborah Giera, Rebecca A. Wright, Bryan G. Johnson, Sherri L. Andis, Ann Kingston, Darryle D. Schoepp

Publikováno v: Journal of Medicinal Chemistry; Jan2007, Vol. 50 Issue 2, p233-240, 8p

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