Acute intermittent hypoxia drives hepatic de novo lipogenesis in humans and rodents

Autor: Hazlehurst, JM, Lim, TR, Charlton, C, Miller, JJ, Gathercole, LL, Cornfield, T, Nikolaou, N, Harris, SE, Moolla, A, Othonos, N, Heather, LC, Marjot, T, Tyler, DJ, Carr, C, Hodson, L, McKeating, J, Tomlinson, JW

Background and aims Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver condition. It is tightly associated with an adverse metabolic phenotype (including obesity and type 2 diabetes) as well as with obstructive sleep apnoea (O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcfce37250d4b1776da0044738b6b008
https://doi.org/10.1016/j.metop.2022.100177

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Examining the immunological effects of COVID-19 vaccination in patients with conditions potentially leading to diminished immune response capacity – the OCTAVE trial

Autor: Kearns, P, Siebert, S, Willicombe, M, Gaskell, C, Kirkham, A, Pirrie, S, Bowden, S, Magwaro, S, Hughes, A, Lim, Z, Dimitriadis, S, Murray, S, Marjot, T, Win, Z, Irwin, S, Meacham, G, Richter, A, Kelleher, P, Satsangi, J, Miller, P, Rea, D, Cook, G, Turtle, L, Klenerman, P, Dunachie, S, Basu, N, Silva, TD, Thomas, D, Barnes, E, Goodyear, C, McInnes, I

SARS-COV-2 vaccines have been shown to be efficacious primarily in healthy volunteer populations and population level studies. Immune responses following SARS-CoV-2 vaccination are less well characterised in potentially immune vulnerable patient grou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::114e81852b377c6c10611c80140e32ad
http://hdl.handle.net/10044/1/97548

Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern

Autor: Skelly, DT, Harding, AC, Gilbert-Jaramillo, J, Knight, ML, Longet, S, Brown, A, Adele, S, Adland, E, Brown, H, Chinnakannan, S, Donnison, T, Ali, M, Rongkard, P, Pace, M, Zacharopoulou, P, Robinson, N, Csala, A, De Lara, C, Hutchings, CL, Mehta, H, Lee, LN, Edmans, M, Hackstein, C-P, Phalora, P, Li, W, Phillips, E, Malone, T, Ogbe, A, Jay, C, Tipoe, T, Tipton, T, Stafford, L, Mentzer, AJ, Johnson, SA, Amini, A, Marjot, T, Dimitriadis, S, Simmons, B, Deeks, A, Kerneis, S, Abuelgasim, H, Wilson, R, Thomas, SR, Watson, A, Alhussni, A, Cutteridge, J, Weeks, E, Denly, L, Lillie, K, Holmes, J, Matthews, PC, O’Donnell, D, Tan, TK, Schimanski, L, Huang, K-YA, Rijal, P, Turtle, L, de Silva, T, Richter, A, Duncan, CJA, Payne, RP, Moore, SC, Knight, JC, Cassar, MP, Raman, B, Neubauer, S, Fries, A, Talbot, NP, Petousi, N, Ho, L-P, Peng, Y, Dong, T, Camara, S, Marinou, S, Linder, A, Adlou, S, Kasanyinga, M, Bridges-Webb, A, Hill, J, Silva-Reyes, L, Blackwell, L, Frater, J, Goulder, P, Conlon, CP, Jeffery, K, Dold, C, Pollard, AJ, Sigal, A, de Oliveira, T, Townsend, AR, Klenerman, P, Dunachie, SJ, Barnes, E, Carroll, MW, James, WS

Publikováno v: Nature Communications

The extent to which immune responses to natural infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and immunization with vaccines protect against variants of concern (VOC) is of increasing importance. Accordingly, here we ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::ce39df3af5380f43937f7f4638fd58b6
https://eprints.whiterose.ac.uk/177331/1/s41467-021-25167-5.pdf

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