Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Marjory Moreau"'
Autor:
Marjory Moreau, Liam Simms, Melvin E. Andersen, Edgar Trelles Sticken, Roman Wieczorek, Sarah Jean Pour, Fiona Chapman, Karin Roewer, Sandra Otte, Jeffrey Fisher, Matthew Stevenson
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
With the use of in vitro new approach methodologies (NAMs) for the assessment of non-combustible next-generation nicotine delivery products, new extrapolation methods will also be required to interpret and contextualize the physiological relevance of
Externí odkaz:
https://doaj.org/article/06e7c45c8815464bb61eca7e8d431b5c
Autor:
Marjory Moreau, Pankajini Mallick, Marci Smeltz, Saad Haider, Chantel I. Nicolas, Salil N. Pendse, Jeremy A. Leonard, Matthew W. Linakis, Patrick D. McMullen, Rebecca A. Clewell, Harvey J. Clewell, Miyoung Yoon
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
High-throughput (HT) in vitro to in vivo extrapolation (IVIVE) is an integral component in new approach method (NAM)-based risk assessment paradigms, for rapidly translating in vitro toxicity assay results into the context of in vivo exposure. When c
Externí odkaz:
https://doaj.org/article/fcd7d8b3f0a74dc38672d8c4d72eb9ac
Autor:
Harvey J. Clewell, Thomas G. Osimitz, R.J. Price, Marjory Moreau, J. Brian Houston, Miyoung Yoon, Moire R. Creek, Carina Cantrill, Larry G. Higgins, Brian G. Lake, Mary P. Scott
Publikováno v:
Xenobiotica. 51:40-50
The kinetics of metabolism of deltamethrin (DLM) and cis- and trans-permethrin (CPM and TPM) was studied in male Sprague-Dawley rat and human liver microsomes. DLM metabolism kinetics was also stud...
Autor:
Marjory Moreau, Pankajini Mallick, Ronald N. Hines, Paul M. Hinderliter, Salil N. Pendse, Thomas G. Osimitz, Harvey J. Clewell, Gina Song, Brian G. Lake, Moire R. Creek, Miyoung Yoon, Alina Efremenko
Publikováno v:
Toxicological Sciences
The assessment of potentially sensitive populations is an important application of risk assessment. To address the concern for age-related sensitivity to pyrethroid insecticides, life-stage physiologically based pharmacokinetic (PBPK) modeling suppor
Autor:
Marjory Moreau, Jeff Fisher, Melvin E. Andersen, Asayah Barnwell, Sage Corzine, Aarati Ranade, Patrick D. McMullen, Scott D. Slattery
Publikováno v:
Toxicology. 481
Time, cost, ethical, and regulatory considerations surrounding in vivo testing methods render them insufficient to meet existing and future chemical safety testing demands. There is a need for the development of in vitro and in silico alternatives to
Autor:
Michael B. Black, Allysa Stern, Alina Efremenko, Pankajini Mallick, Marjory Moreau, Jessica K. Hartman, Patrick D. McMullen
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 80
There is increasing interest in using modern 'omics technologies, such as whole transcriptome sequencing, to inform decisions about human health safety and chemical toxicity hazard. High throughput methodologies using in vitro assays offer a path for
Autor:
Roger J, Price, Mary P, Scott, Carina, Cantrill, Larry G, Higgins, Marjory, Moreau, Miyoung, Yoon, Harvey J, Clewell, Moire R, Creek, Thomas G, Osimitz, J Brian, Houston, Brian G, Lake
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 51(1)
The kinetics of metabolism of deltamethrin (DLM) and
Autor:
Susan Brown, Marjory Moreau, A. Kenneth MacLeod, Thomas G. Osimitz, Laura Hedges, Miyoung Yoon, Brian G. Lake, Gina Song, Edward Doyle, Audrey Vardy
Publikováno v:
Xenobiotica. 49:521-527
The metabolism of the pyrethroids deltamethrin (DLM), cis-permethrin (CPM) and trans-permethrin (TPM) was studied in human expressed cytochrome P450 (CYP) and carboxylesterase (CES) enzymes. DLM, CPM and TPM were metabolised by human CYP2B6 and CYP2C
Autor:
Marjory Moreau, Yu-Mei Tan, Martin B. Phillips, Katherine Phillips, Harvey J. Clewell, Sherrie Smith, Kristin Isaacs, Jeremy A. Leonard, Salil N. Pendse, Miyoung Yoon, Chantel I. Nicolas, Jerry L. Campbell, Harish Pudukodu
Publikováno v:
Chemosphere
A few different exposure prediction tools were evaluated for use in the new in vitro -based safety assessment paradigm using di-2-ethylhexyl phthalate (DEHP) and dibutyl phthalate (DnBP) as case compounds. Daily intake of each phthalate was estimated
Autor:
Miyoung Yoon, Marjory Moreau, Ronald N. Hines, Thomas G. Osimitz, Alina Efremenko, Harvey J. Clewell, Brian G. Lake, Paul M. Hinderliter, Gina Song, Moire R. Creek, Salil N. Pendse, Pankajini Mallick
Publikováno v:
Toxicological Sciences
To address concerns around age-related sensitivity to pyrethroids, a life-stage physiologically based pharmacokinetic (PBPK) model, supported by in vitro to in vivo extrapolation (IVIVE) was developed. The model was used to predict age-dependent chan