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Autor:
Maike Sander, Mercè Martín, Jochen Barths, Christophe Orvain, Georg Mellitzer, Marjorie Sidhoum-Jenny, Philip A. Seymour, Gérard Gradwohl
Publikováno v:
Molecular Endocrinology. 18:2765-2776
The basic helix-loop-helix transcription factor Neurogenin 3 (NGN3) controls endocrine cell fate specification in uncommitted pancreatic progenitor cells. Ngn3-deficient mice do not develop any islet cells and are diabetic. All the major islet cell t