Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Marjorie S. Waters"'
Autor:
Ian W. Davies, Paul N. Devine, Robert A. Reamer, David M. Tschaen, Fei Zhang, Daniel Zewge, Jeffrey T. Kuethe, David R. Lieberman, Zhihui Peng, Kevin M. Belyk, David M. Tellers, Guy R. Humphrey, Peter G. Dormer, Michel Journet, Andrew Nolting, Marjorie S. Waters, Dalian Zhao, Zhiguo J. Song
Publikováno v:
The Journal of Organic Chemistry. 76:7804-7815
Development of a practical synthesis of MK-7009, a 22-membered macrocycle, is described. A variety of ring-closing strategies were evaluated, including ring-closing metathesis, intermolecular palladium-catalyzed cross-couplings, and macrolactamizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1dc6683cb1f9b4cbaa077ffc9b2d32f
https://doi.org/10.1021/jo2011494
https://doi.org/10.1021/jo2011494
Publikováno v:
Synthesis. 2008:891-896
Herein is described the development and use of a novel bis(dialkylamino)sulfur difluoride reagent to effect the stereoselective conversion of a benzylic alcohol into a benzylic fluoride. A new method for the synthesis of 1 H-pyrazolo[3,4- D]pyrimidin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::671ca93449c6ec54e4bf2df2bceef576
https://doi.org/10.1055/s-2008-1032181
https://doi.org/10.1055/s-2008-1032181
Publikováno v:
Synthesis. 2006:3389-3396
A novel sulfoxide-directed borane reduction was shown to give a variety of 2-substituted 1,4-dihydrobenzoxathiins. For all substrates evaluated, the reaction is completely stereospecific. Application of this methodology to the chiral synthesis of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c875279a4faae07ac79cdf9581c191a0
https://doi.org/10.1055/s-2006-950243
https://doi.org/10.1055/s-2006-950243
Autor:
Robert A. Reamer, David M. Tschaen, Edward J. J. Grabowski, Elizabeth Buck, Ralph P. Volante, Feng Xu, Marjorie S. Waters, Kimberly A. Savary, Matthew M. Bio, Chunhua Yang, Cameron J. Cowden, Zhiguo J. Song, J. Michael Williams
Publikováno v:
The Journal of Organic Chemistry. 69:6257-6266
A practical, efficient synthesis of 1, a hepatitis C virus RNA replication inhibitor, is described. Starting with the inexpensive diacetone glucose, the 12-step synthesis features a novel stereoselective rearrangement to prepare the key crystalline f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5755c2f58081e7737a80d5c4a0b032
https://doi.org/10.1021/jo0491096
https://doi.org/10.1021/jo0491096
Autor:
Robert A. Reamer, Ralph P. Volante, Peter E. Maligres, David Askin, Jennifer A. Cowen, J. Christopher McWilliams, Steven A. Weissman, Paul J. Reider, Stephanie Lewis, Marjorie S. Waters
Publikováno v:
Journal of Heterocyclic Chemistry. 40:229-241
The synthesis of ras farnesyl-protein transferase inhibitor 1 is described on a multi-kilogram scale. Retrosynthetic analysis reveals chloromethylimidazole 2 and a piperazinone 3 as viable precursors. The 1,5-disubstituted imidazole system was regios
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::263e91f3e5b88912b24019837ff21a59
https://doi.org/10.1002/jhet.5570400206
https://doi.org/10.1002/jhet.5570400206
Autor:
Jennifer A. Cowen, Marjorie S. Waters, David Askin, Peter E. Maligres, J. Christopher McWilliams
Publikováno v:
Tetrahedron Letters. 41:141-144
Aryl alkynols provide a convenient entry into α-hydroxyketones via thiol addition followed by hydrolysis. Thiols have been added to several non-activated alkynes under mild, basic conditions. A coordinating functional group in close proximity to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18adf4d74ef02ec1d4a93d99dc774d72
https://doi.org/10.1016/s0040-4039(99)02040-7
https://doi.org/10.1016/s0040-4039(99)02040-7
Publikováno v:
Synthesis. 2007:2779-2781
A short, high yielding, five-step synthesis of the pharmaceutically interesting fluorinated heterocycle, 3-[2,2,2-trifluoroethyl]hexahydro-2 H-1,4-diazepin-2-one, has been developed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d6453cd58596fbe31841fe707ac6c08
https://doi.org/10.1055/s-2007-983876
https://doi.org/10.1055/s-2007-983876
Autor:
Zhiguo J, Song, David M, Tellers, Michel, Journet, Jeffrey T, Kuethe, David, Lieberman, Guy, Humphrey, Fei, Zhang, Zhihui, Peng, Marjorie S, Waters, Daniel, Zewge, Andrew, Nolting, Dalian, Zhao, Robert A, Reamer, Peter G, Dormer, Kevin M, Belyk, Ian W, Davies, Paul N, Devine, David M, Tschaen
Publikováno v:
The Journal of organic chemistry. 76(19)
Development of a practical synthesis of MK-7009, a 20-membered [corrected] macrocycle, is described. A variety of ring-closing strategies were evaluated, including ring-closing metathesis, intermolecular palladium-catalyzed cross-couplings, and macro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2bb5f059883663ed6ee0261389245e02
https://pubmed.ncbi.nlm.nih.gov/21838271
https://pubmed.ncbi.nlm.nih.gov/21838271
Publikováno v:
ChemInform. 31
A dependable high yielding palladium catalyzed aryl bromide cyanation procedure has been developed. The optimized cyanation features extremely low levels of palladium and DPPF ligand.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0a8a46e4e85e70be030b467c7bc9369
https://doi.org/10.1002/chin.200005099
https://doi.org/10.1002/chin.200005099
Autor:
David Askin, Marjorie S. Waters, J. Christopher McWilliams, Peter E. Maligres, Jennifer A. Cowen
Publikováno v:
ChemInform. 31
Aryl alkynols provide a convenient entry into α-hydroxyketones via thiol addition followed by hydrolysis. Thiols have been added to several non-activated alkynes under mild, basic conditions. A coordinating functional group in close proximity to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7a34f90b190ad04dc4ff9a6a24f6ed4
https://doi.org/10.1002/chin.200012097
https://doi.org/10.1002/chin.200012097