A lipid-binding protein mediates rhoptry discharge and invasion in Plasmodium falciparum and Toxoplasma gondii parasites

Autor: Catherine Suarez, Gaëlle Lentini, Raghavendran Ramaswamy, Marjorie Maynadier, Eleonora Aquilini, Laurence Berry-Sterkers, Michael Cipriano, Allan L. Chen, Peter Bradley, Boris Striepen, Martin J. Boulanger, Maryse Lebrun

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Plasmodium and Toxoplasma parasites rely on rhoptry exocytosis for invasion, but the underlying mechanism is not known. Here, Suarez et al. characterize rhoptry apical surface proteins (RASP) that localize to the rhoptry cap and bind charged lipids,

Externí odkaz: https://doaj.org/article/5d7eb981430d428a86981e90c449cc6b

Hydroxyl Ketone-Based Histone Deacetylase Inhibitors To Gain Insight into Class I HDAC Selectivity versus That of HDAC6

Autor: Mohamed D. M. Traoré, Vincent Zwick, Claudia A. Simões-Pires, Alessandra Nurisso, Mark Issa, Muriel Cuendet, Marjorie Maynadier, Sharon Wein, Henri Vial, Helene Jamet, Yung-Sing Wong

Publikováno v: ACS Omega, Vol 2, Iss 4, Pp 1550-1562 (2017)

Externí odkaz: https://doaj.org/article/ee61c804c38643ec997c1930494af5e4

An apical membrane complex for triggering rhoptry exocytosis and invasion in Toxoplasma

Autor: Daniela Sparvoli, Jason Delabre, Diana Marcela Penarete‐Vargas, Shrawan Kumar Mageswaran, Lev M Tsypin, Justine Heckendorn, Liam Theveny, Marjorie Maynadier, Marta Mendonça Cova, Laurence Berry‐Sterkers, Amandine Guérin, Jean‐François Dubremetz, Serge Urbach, Boris Striepen, Aaron P Turkewitz, Yi‐Wei Chang, Maryse Lebrun

Publikováno v: The EMBO journal. 41(22)

Apicomplexan parasites possess secretory organelles called rhoptries that undergo regulated exocytosis upon contact with the host. This process is essential for the parasitic lifestyle of these pathogens and relies on an exocytic machinery sharing st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e3c564b8c722e329ed845bf0172ca1
https://pubmed.ncbi.nlm.nih.gov/36245278

A lipid-binding protein mediates rhoptry discharge and invasion in Plasmodium falciparum and Toxoplasma gondii parasites

Autor: Allan L. Chen, Marjorie Maynadier, Boris Striepen, Michael J. Cipriano, Laurence Berry-Sterkers, Catherine Suarez, Peter J. Bradley, Gaelle Lentini, Eleonora Aquilini, Martin J. Boulanger, Raghavendran Ramaswamy, Maryse Lebrun

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications

Members of the Apicomplexa phylum, including Plasmodium and Toxoplasma, have two types of secretory organelles (micronemes and rhoptries) whose sequential release is essential for invasion and the intracellular lifestyle of these eukaryotes. During i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d261233745799f550e228ce5d5aa97df
https://doaj.org/article/5d7eb981430d428a86981e90c449cc6b

G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents

Autor: Jose Juan Lopez-Rubio, Michela Zuffo, Juan Carlos Morales, Jean-Louis Mergny, Jenny Campos-Salinas, José M. Pérez-Victoria, Matilde Arévalo-Ruiz, Filippo Doria, Efres Belmonte-Reche, Marta Martínez-García, Mauro Freccero, Aurore Guédin, Marjorie Maynadier

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (3), pp.1231-1240. ⟨10.1021/acs.jmedchem.7b01672⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname

G-quadruplexes (G4) are DNA secondary structures that take part in the regulation of gene expression. Putative G4 forming sequences (PQS) have been reported in mammals, yeast, bacteria, and viruses. Here, we present PQS searches on the genomes of T.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b37134663c264709b225f4f349119ae
http://hdl.handle.net/10261/163518