Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Marjorie Maillet"'
Autor:
Tobias G. Schips, Davy Vanhoutte, Alexander Vo, Robert N. Correll, Matthew J. Brody, Hadi Khalil, Jason Karch, Andoria Tjondrokoesoemo, Michelle A. Sargent, Marjorie Maillet, Robert S. Ross, Jeffery D. Molkentin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Thrombospondin 4 has been shown to protect the heart and the skeletal muscle by enhancing matrix secretion and membrane stability thanks to its intracellular function. Here the authors show that thrombospondin 3 exacerbates injury-induced cardiomyopa
Externí odkaz:
https://doaj.org/article/74b8489711b44584b0c9cd975dc56e06
Autor:
Jeffery D. Molkentin, Anne Katrine Z. Johansen, Sakthivel Sadayappan, Jennifer A. Schwanekamp, Vincent Huang, Marjorie Maillet, Matthias Nahrendorf, Michelle A. Sargent, Hadi Khalil, Allen J. York, Ronald J. Vagnozzi
Publikováno v:
Nature
Clinical trials using adult stem cells to regenerate damaged heart tissue continue to this day1,2, despite ongoing questions of efficacy and a lack of mechanistic understanding of the underlying biological effect3. The rationale for these cell therap
Autor:
Jennifer A. Schwanekamp, Marjorie Maillet, Vincent Huang, Ronald J. Vagnozzi, Allen J. York, Michelle A. Sargent, Sakthivel Sadayappan, Hadi Khalil, Matthias Nahrendorf, Jeffery D. Molkentin, Anne Katrine Z. Johansen
Clinical trials using adult stem cells to regenerate damaged heart tissue continue to this day1–3 despite ongoing questions of efficacy and a lack of mechanistic understanding of the underlying biologic effect4–6. The rationale for these cell the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2322d50b6b3db8a79a9eb4a8ae43e7a
https://doi.org/10.1101/506626
https://doi.org/10.1101/506626
Autor:
Marjorie Maillet, Tran H Nguyen, Davy Vanhoutte, Meera C. Viswanathan, Michelle A. Sargent, Anthony Cammarato, Jeffery D. Molkentin, Allen J. York, Matthew J. Brody
Publikováno v:
Circulation Research. 123
Valosin Containing Protein (VCP)/p97 is a AAA-ATPase with functions in vast cellular protein quality control processes, including targeting of misfolded or aggregated proteins for degradation by the ubiquitin proteasome system and autophagy. Mutation
Publikováno v:
Circulation Research. 123
A better understating of the mechanisms by which cardiomyocytes grow in different directions could open up new therapeutic avenues for hypertrophic and dilated cardiomyopathies, diseases that include the lengthening and widening of cardiomyocytes, re
Autor:
Ronald J, Vagnozzi, Marjorie, Maillet, Michelle A, Sargent, Hadi, Khalil, Anne Katrine Z, Johansen, Jennifer A, Schwanekamp, Allen J, York, Vincent, Huang, Matthias, Nahrendorf, Sakthivel, Sadayappan, Jeffery D, Molkentin
Publikováno v:
Nature. 577(7790)
Clinical trials using adult stem cells to regenerate damaged heart tissue continue to this day
Autor:
Thomas P. Cappola, Nathan R. Tucker, Ray Hu, Ramachandran S. Vasan, François Cambien, Janine F. Felix, Pim van der Harst, Cecilia E. Kim, Honghuang Lin, Victoria A. Parsons, W.H. Wilson Tang, Kenneth B. Margulies, Michael Morley, Christine S. Moravec, Nicholas L. Smith, Euan A. Ashley, Jin Li, Jeffrey Brandimarto, Marjorie Maillet, Hugo A. Katus, Benjamin Meder, Eric Villard, Patrick T. Ellinor, Sridhar Hannenhalli, Monika Stoll, Frank Rühle, Hakon Hakonarson, Sihai Dave Zhao, Jeffery D. Molkentin, Christopher Newton-Cheh
Publikováno v:
Circulation-cardiovascular genetics, 11(3):UNSP e001901. Lippincott Williams & Wilkins
Circulation-Cardiovascular Genetics, 11(3):001901. LIPPINCOTT WILLIAMS & WILKINS
Circulation-Cardiovascular Genetics, 11(3):001901. LIPPINCOTT WILLIAMS & WILKINS
Background: Inhibition of PKC-α (protein kinase C-α) enhances contractility and cardioprotection in animal models, but effects in humans are unknown. Genotypes at rs9912468 strongly associate with PRKCA expression in the left ventricle, enabling ge
Autor:
Tobias G Schips, Davy Vanhoutte, Matthew Brody, Nathan Correll, Andoria Tjondrokoesoemo, Michelle Sargent, Marjorie Maillet, Jeffery D Molkentin
Publikováno v:
Circulation Research. 121
Thrombospondin (Thbs) proteins are multidomain, matricellular proteins comprised of 5 genes that each share similar domains and have been largely ascribed the same functional characteristics. The Thbs protein family is divided in 2 subgroups based on
Publikováno v:
Journal of Clinical Investigation. 123:37-45
Cardiovascular disease is the number one cause of mortality in the Western world. The heart responds to many cardiopathological conditions with hypertrophic growth by enlarging individual myocytes to augment cardiac pump function and decrease ventric
Publikováno v:
Nature Reviews Molecular Cell Biology. 14:38-48
The heart hypertrophies in response to developmental signals as well as increased workload. Although adult-onset hypertrophy can ultimately lead to disease, cardiac hypertrophy is not necessarily maladaptive and can even be beneficial. Progress has b