Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Marjorie F. Lou"'
Publikováno v:
Guoji Yanke Zazhi, Vol 20, Iss 3, Pp 420-425 (2020)
AIM: To examine the morphological and biochemical alterations in the eyes of Thioltransferase knockout(TTase KO)mouse model as a function of age, and to explore the important function in redox homeostasis in the lens and in the age-related cataractog
Externí odkaz:
https://doaj.org/article/a1fc99dafdf14191aa4567d3f3bc4d42
Autor:
Marjorie F. Lou
Publikováno v:
Antioxidants, Vol 11, Iss 10, p 1973 (2022)
The ocular lens has a very high content of the antioxidant glutathione (GSH) and the enzymes that can recycle its oxidized form, glutathione disulfide (GSSG), for further use. It can be synthesized in the lens and, in part, transported from the neigh
Externí odkaz:
https://doaj.org/article/ac1fb7a252df484582b5b2822b12c699
Autor:
K. Krishna Sharma, Peter F. Kador, Ashutosh S. Phadte, Marjorie F. Lou, Puttur Santhoshkumar, Damian M. Daszynski, Haizhen A. Zhong
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
The paradigm that cataracts are irreversible and that vision from cataracts can only be restored through surgery has recently been challenged by reports that oxysterols such as lanosterol and 25-hydroxycholesterol can restore vision by binding to αB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f48cba3f41f04ae1fafb52d4b945629
http://link.springer.com/article/10.1038/s41598-019-44676-4
http://link.springer.com/article/10.1038/s41598-019-44676-4
Publikováno v:
Experimental Eye Research. 130:58-65
Glutaredoxin2 (Grx2) is a mitochondrial isozyme of the cytosolic glutaredoxin1 (thioltransferase or TTase). Both belong to the large oxidoreductase family and play an important role in maintaining thiol/disulfide redox homeostasis in the cells. Grx2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::730a6f2b04736a5e4c78f9e10f5552d9
https://doi.org/10.1016/j.exer.2014.12.004
https://doi.org/10.1016/j.exer.2014.12.004
Publikováno v:
Investigative Ophthalmology & Visual Science. 56:598-605
Purpose The purpose of this study was to investigate the thiol repair systems of thioltransferase (TTase) and thioredoxin (Trx) and oxidation-damaged proteins in human cataractous lenses. Methods Cataractous lenses in humans (57-85 years of age) were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd77a19fc13769718152cc1ff95e5a6
https://doi.org/10.1167/iovs.14-15452
https://doi.org/10.1167/iovs.14-15452
Publikováno v:
Experimental eye research. 161
Oxidative stress is a known risk factor in senile cataract formation. In recent years, it has been suggested that oxidation may also be associated with cataract induced by hyperglycemia, but this concept has not been well examined or validated. Since
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29eb92045d03e28561d560b745a38381
https://pubmed.ncbi.nlm.nih.gov/28579033
https://pubmed.ncbi.nlm.nih.gov/28579033
Autor:
Jean da Silva, Skye McBride, Mary-Ellen Harper, Jian Ying Xuan, Marjorie F. Lou, Robert A. deKemp, Chris R. J. Kennedy, Peter Rippstein, Stephanie Thorn, Mona Nemer, Ryan J. Mailloux, Chet E. Holterman, Wael Maharsy
Publikováno v:
Journal of Biological Chemistry. 289:14812-14828
Glutaredoxin-2 (Grx2) modulates the activity of several mitochondrial proteins in cardiac tissue by catalyzing deglutathionylation reactions. However, it remains uncertain whether Grx2 is required to control mitochondrial ATP output in heart. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb736b4dc0337e22e8694cac31383a4
https://doi.org/10.1074/jbc.m114.550574
https://doi.org/10.1074/jbc.m114.550574
Autor:
Mary-Ellen Harper, Marjorie F. Lou, Linda Jui, Jian Ying Xuan, Brittany Beauchamp, Ryan J. Mailloux
Publikováno v:
Journal of Biological Chemistry. 288:8365-8379
Glutathionylation has emerged as a key modification required for controlling protein function in response to changes in cell redox status. Recently, we showed that the glutathionylation state of uncoupling protein-3 (UCP3) modulates the leak of proto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f792747fe16e5062efa4f32bd9011b1
https://doi.org/10.1074/jbc.m112.442905
https://doi.org/10.1074/jbc.m112.442905
Publikováno v:
Experimental Eye Research. 101:36-43
In sugar cataract formation in rats, aldose reductase (AR) actitvity is not only linked to lenticular sorbitol (diabetic) or galactitol (galactosemic) formation but also to signal transduction changes, cytotoxic signals and activation of apoptosis. U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60753d17f8538852afe06202d27bfd63
https://doi.org/10.1016/j.exer.2012.05.007
https://doi.org/10.1016/j.exer.2012.05.007
Publikováno v:
Free Radical Biology and Medicine. 51:2108-2117
Glutaredoxin belongs to the oxidoreductase family, with cytosolic glutaredoxin 1 (Grx1) and mitochondrial glutaredoxin 2 (Grx2) isoforms. Of the two isozymes, the function of Grx2 is not well understood. This paper describes the effects of Grx2 delet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91a1ed8bf6d533cf1b54f1402b1b9aca
https://doi.org/10.1016/j.freeradbiomed.2011.09.011
https://doi.org/10.1016/j.freeradbiomed.2011.09.011