Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Marjorie A. Mohler"'
Investigation of the pharmacokinetics and metabolism of human proteins has escalated over the last two decades because of the use of recombinant human proteins as therapeutic agents. In addition, the development and improvement of analytical techniqu
Publikováno v:
The American Journal of Surgery. 176:55S-60S
Becaplermin (recombinant human platelet-derived growth factor-BB [BB homodimer, rhPDGF-BB]) has demonstrated a favorable safety profile in a series of nonclinical studies designed to assess its systemic toxicity, sensitization, local irritation, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12b1c1bf9758fe1c6da92e78d9e8f02c
https://doi.org/10.1016/s0002-9610(98)00176-7
https://doi.org/10.1016/s0002-9610(98)00176-7
Publikováno v:
Pharmaceutical Biotechnology ISBN: 9781489923318
Numerous examples of binding proteins for protein therapeutics have been reported. Binding proteins have been shown to exist for insulinlike growth factors I and II, tissue plasminogen activator, growth hormone, deoxyribonuclease I, tissue factor, ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ae76031f29c97f914419f371e21cec6
https://doi.org/10.1007/978-1-4899-2329-5_2
https://doi.org/10.1007/978-1-4899-2329-5_2
Publikováno v:
Pharmaceutical Biotechnology ISBN: 9781489923318
Protein Pharmacokinetics and Metabolism
Protein Pharmacokinetics and Metabolism
Goals and Analytical Methodologies for Protein Disposition Studies B.L. Ferraiolo, M.A. Mohler. Binding Proteins of Protein Therapeutics M.A. Mohler, et al. Potential Effects of Antibody Induction by Protein Drugs P.K. Working. Pharmacokinetics and M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e91081a2346f0c1702eaeded38db5c71
https://doi.org/10.1007/978-1-4899-2329-5
https://doi.org/10.1007/978-1-4899-2329-5
Autor:
Paul D. Johnston, Marjorie A. Mohler, Brian M. Fendly, Susan M. Kramer, Daniel W. Drolet, Ursula E. M. Gibson
Publikováno v:
In vitro cellulardevelopmental biology : journal of the Tissue Culture Association. 26(6)
A novel relaxin sensitive cell line of apparent smooth muscle origin has been established from a newborn rhesus monkey uterus (NRMU). NRMU cells respond to relaxin, in the presence of 1 microM forskolin, by producing intracellular adenosine 3', 5'-cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f00c8f991f1611ad059ce700aaca34c
https://pubmed.ncbi.nlm.nih.gov/2162818
https://pubmed.ncbi.nlm.nih.gov/2162818
Publikováno v:
Cellular Immunology. 84:324-332
A human/mouse hybridoma was developed which has the property of secreting a human bone resorbing factor similar or identical to the osteoclast activating factor (OAF) isolated from human tonsil lymphocytes. Mouse plasmacytoma cells negative for OAF p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c373a8269e8f19af5a572a4d408bcd0a
https://doi.org/10.1016/0008-8749(84)90104-7
https://doi.org/10.1016/0008-8749(84)90104-7
Publikováno v:
Journal of Clinical Investigation. 64:337-341
The human lympholine osteoclast activating factor (OAF) is thought to be involved in several bone-destroying diseases. The current studies were designed to produce monoclonal antibodies against OAF for use in the subsequent design of immunoassays for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ade967da34212e64b6054acf7e71a5
https://doi.org/10.1172/jci109459
https://doi.org/10.1172/jci109459
Autor:
Richard A. Luben, Marjorie A. Mohler
Publikováno v:
Molecular immunology. 17(5)
A system is described for production of hybridomas which secrete antibodies against the lymphokine osteoclast activating factor (OAF). The system consists of immunization of mouse spleen cells in vitro with purified or semipurified human OAF, followe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00c9d384899c9e84e3fdd4cfee1f12c
https://pubmed.ncbi.nlm.nih.gov/7194419
https://pubmed.ncbi.nlm.nih.gov/7194419
Publikováno v:
Calcified tissue international. 28(1)
Osteoclast activating factor (OAF) is a lymphokine which may participate in the pathologic destruction of bone observed in a number of disorders. In the current studies, we investigated the action of OAF on cAMP accumulation by bones and isolated bon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c38c856c5c8240bc8b9245d5e27fcb
https://pubmed.ncbi.nlm.nih.gov/227549
https://pubmed.ncbi.nlm.nih.gov/227549