Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Marjon J.A.M. Verstegen"'
Autor:
Willem K. Smits, Carlo Vermeulen, Rico Hagelaar, Shunsuke Kimura, Eric M. Vroegindeweij, Jessica G.C.A.M. Buijs-Gladdines, Ellen van de Geer, Marjon J.A.M. Verstegen, Erik Splinter, Simon V. van Reijmersdal, Arjan Buijs, Niels Galjart, Winfried van Eyndhoven, Max van Min, Roland Kuiper, Patrick Kemmeren, Charles G. Mullighan, Wouter de Laat, Jules P.P. Meijerink
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112373- (2023)
Summary: Monoallelic inactivation of CCCTC-binding factor (CTCF) in human cancer drives altered methylated genomic states, altered CTCF occupancy at promoter and enhancer regions, and deregulated global gene expression. In patients with T cell acute
Externí odkaz:
https://doaj.org/article/6b893ca121c74b21b92992c09f74bf69
Autor:
Ruiqi Han, Yike Huang, Iwan Vaandrager, Amin Allahyar, Mikhail Magnitov, Marjon J.A.M. Verstegen, Elzo de Wit, Peter H.L. Krijger, Wouter de Laat
The cohesin complex (SMC1-SMC3-RAD21) shapes chromosomes by DNA loop extrusion, but individual extrusion trajectories were so far unappreciable in vivo. Here, we site-specifically induced dozens of extrusion trajectories anchored at artificial loadin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::549c3766e744f2f609090e917c46ece7
https://doi.org/10.1101/2023.01.04.522689
https://doi.org/10.1101/2023.01.04.522689
Autor:
Joost Vermaat, Tom van Wezel, Paula J P de Vree, Wouter de Laat, Bauke Ylstra, Amin Allahyar, Marieke Simonis, Harma Feitsma, Adrien S. J. Melquiond, Max van Min, Agata Rakszewska, Erik Splinter, Daphne de Jong, Joost Swennenhuis, Milan Sharma, Mehmet Yilmaz, Arjan Diepstra, Roos J Leguit, Robert van der Geize, Phylicia Stathi, Karima Hajo, Nathalie J. Hijmering, Mark Pieterse, Marjon J.A.M. Verstegen, Peter H.L. Krijger, Ruud W J Meijers, G Tjitske Los-de Vries, Léon C van Kempen, Arjen H.G. Cleven
Publikováno v:
Nature Communications, 12(1):3361. Nature Publishing Group
Nature Communications
Nature Communications, 12(1). Nature Publishing Group
Nature Communications, 12(1). NATURE PORTFOLIO
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Allahyar, A, Pieterse, M, Swennenhuis, J, Los-de Vries, G T, Yilmaz, M, Leguit, R, Meijers, R W J, van der Geize, R, Vermaat, J, Cleven, A, van Wezel, T, Diepstra, A, van Kempen, L O C, Hijmering, N J, Stathi, P, Sharma, M, Melquiond, A S J, de Vree, P J P, Verstegen, M J A M, Krijger, P H L, Hajo, K, Simonis, M, Rakszewska, A, van Min, M, de Jong, D, Ylstra, B, Feitsma, H, Splinter, E & de Laat, W 2021, ' Robust detection of translocations in lymphoma FFPE samples using targeted locus capture-based sequencing ', Nature Communications, vol. 12, no. 1, 3361 . https://doi.org/10.1038/s41467-021-23695-8
Nature Communications
Nature Communications, 12(1). Nature Publishing Group
Nature Communications, 12(1). NATURE PORTFOLIO
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Allahyar, A, Pieterse, M, Swennenhuis, J, Los-de Vries, G T, Yilmaz, M, Leguit, R, Meijers, R W J, van der Geize, R, Vermaat, J, Cleven, A, van Wezel, T, Diepstra, A, van Kempen, L O C, Hijmering, N J, Stathi, P, Sharma, M, Melquiond, A S J, de Vree, P J P, Verstegen, M J A M, Krijger, P H L, Hajo, K, Simonis, M, Rakszewska, A, van Min, M, de Jong, D, Ylstra, B, Feitsma, H, Splinter, E & de Laat, W 2021, ' Robust detection of translocations in lymphoma FFPE samples using targeted locus capture-based sequencing ', Nature Communications, vol. 12, no. 1, 3361 . https://doi.org/10.1038/s41467-021-23695-8
In routine diagnostic pathology, cancer biopsies are preserved by formalin-fixed, paraffin-embedding (FFPE) procedures for examination of (intra-) cellular morphology. Such procedures inadvertently induce DNA fragmentation, which compromises sequenci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f015170cc76e934c99a06da52084f3ba
https://research.vumc.nl/en/publications/dbd7c41c-2950-4947-b268-32207673d8fd
https://research.vumc.nl/en/publications/dbd7c41c-2950-4947-b268-32207673d8fd
Autor:
Teodora Filipovska, Zaria de Andrade dos Ramos, Marjon J.A.M. Verstegen, Niels J. Rinzema, Stefan van der Elst, Peter H.L. Krijger, Sjoerd J. D. Tjalsma, Ruiqi Han, Anna-Karina Felder, Konstantinos Sofiadis, Wouter de Laat, Yuva Oz, Christian Valdes-Quezada
Developmental gene expression is often controlled by distal tissue-specific enhancers. Enhancer action is restricted to topological chromatin domains, typically formed by cohesin-mediated loop extrusion between CTCF-associated boundaries. To better u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4876d05b47a57dd0f54464338106fe7c
https://doi.org/10.1101/2021.10.05.463209
https://doi.org/10.1101/2021.10.05.463209
Autor:
Wouter de Laat, Anton van Weert, Sanne Boersma, Peter H.L. Krijger, Lieke I P M Donders, Jo Vandesompele, Rene J T M Roymans, Stefan Meijer, Francesca Mattiroli, Tim A. Hoek, Pim W. Toonen, Edwin Dekker, Monique Nijhuis, Thomas W van Ravesteyn, Ive Logister, Fred J Dom, Maaike Broeders, Mark Pieterse, Lieven B J van der Velden, Martijn Bosch, Bram M.P. Verhagen, Marvin E. Tanenbaum, Marjon J.A.M. Verstegen, Jeroen H.B. van de Bovenkamp, Rob Ruijtenbeek
Publikováno v:
Nature Biotechnology, 39(10), 1182-1184. Nature Publishing Group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf13f7adf6a0ecc214d0a147ddeb3bf
https://pure.knaw.nl/portal/en/publications/4f9be3a2-c913-455b-aeeb-b0f8bf0d8146
https://pure.knaw.nl/portal/en/publications/4f9be3a2-c913-455b-aeeb-b0f8bf0d8146
Autor:
Anna-Karina Felder, Floor van der Vegt, Christian Valdes-Quezada, Wouter de Laat, Esther C.H. Uijttewaal, Amin Allahyar, Peter H.L. Krijger, E.S. Vos, Yike Huang, Marjon J.A.M. Verstegen
Publikováno v:
Molecular Cell, 81(15), 3082-3095.e6. Cell Press
Nature Genetics
Nature Genetics
To understand how chromatin domains coordinate gene expression, we dissected select genetic elements organizing topology and transcription around the Prdm14 super enhancer in mouse embryonic stem cells. Taking advantage of allelic polymorphisms, we d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8281448c446a0236b43ea83fe6982de5
https://pure.knaw.nl/portal/en/publications/b95644d7-6943-4241-ba98-bb921ebeb393
https://pure.knaw.nl/portal/en/publications/b95644d7-6943-4241-ba98-bb921ebeb393
Autor:
Eric M. Vroegiindeweij, Patrick Kemmeren, Shunsuke Kimura, Ellen van de Geer-de Jong, Jules P.P. Meijerink, Wouter de Laat, Charles G. Mullighan, Simon V. van Reijmersdal, Niels Galjart, Jessica G.C.A.M. Buijs-Gladdines, Marjon J.A.M. Verstegen, Carlo Vermeulen, Winfried van Eijndhoven, Roland P. Kuiper, Willem K. Smits, Erik Splinter, Rico Hagelaar, Max van Min, Arjan Buijs
Publikováno v:
SSRN Electronic Journal.
Inactivating mutations in the CCCTC-binding factor (CTCF) in human cancer drive altered methylated genomic states, altered CTCF occupancy at promotor and enhancer regions and deregulate global gene expression. In T-ALL patients, we found that acquire
Autor:
Marjon J.A.M. Verstegen, Jeroen de Ridder, Ivo Renkens, Carlo Vermeulen, Wigard P. Kloosterman, Wouter de Laat, Britta A M Bouwman, Roy Straver, Peter H.L. Krijger, Christian Valdes-Quezada, Geert Geeven, Amin Allahyar
Publikováno v:
Nature Protocols, 15(2), 364-397. Nature Publishing Group
Nature Protocols, 15(2), 364. Nature Publishing Group
Nature Protocols, 15(2), 364. Nature Publishing Group
We present the experimental protocol and data analysis toolbox for multi-contact 4C (MC-4C), a new proximity ligation method tailored to study the higher-order chromatin contact patterns of selected genomic sites. Conventional chromatin conformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e3fdcee30fb37bdcefb214e2021ae2
https://pure.knaw.nl/portal/en/publications/28abd704-3741-4ef3-9d0d-4a1562c34cee
https://pure.knaw.nl/portal/en/publications/28abd704-3741-4ef3-9d0d-4a1562c34cee
Autor:
Carlo Vermeulen, Marjon J.A.M. Verstegen, Wigard P. Kloosterman, Mark Pieterse, Hans Teunissen, Britta A M Bouwman, Judith H.I. Haarhuis, Amin Allahyar, Peter H.L. Krijger, Elzo de Wit, Jeroen de Ridder, Ivo Renkens, Roy Straver, Benjamin D. Rowland, Kees Jalink, Wouter de Laat, Geert Geeven, Melissa van Kranenburg
Publikováno v:
Nature Genetics, 50(8), 1151-1160. Nature Publishing Group
Nature Genetics
Nature Genetics, 50(8), 1151. Nature Publishing Group
Nature Genetics
Nature Genetics, 50(8), 1151. Nature Publishing Group
Chromatin folding contributes to the regulation of genomic processes such as gene activity. Existing conformation capture methods characterize genome topology through analysis of pairwise chromatin contacts in populations of cells but cannot discern
Autor:
Carlo Vermeulen, Eric Vroegindeweij, Jessica G.C.A.M. Buijs-Gladdines, Ellen van de Geer, Max van Min, Charles G. Mullighan, Willem K. Smits, Niels Galjart, Marjon J.A.M. Verstegen, Roland P. Kuiper, Arjan Buijs, Jules P.P. Meijerink, Rico Hagelaar, Shunsuke Kimura, Winfried Van Eyndhoven, Patrick Kemmeren, Simon V. van Reijmersdal, Wouter de Laat, Erik Splinter
Publikováno v:
Blood. 138:501-501
Introduction. The CCCTC-binding factor (CTCF) regulates the 3D chromatin architecture by facilitating chromosomal loops and forming the boundaries of structural domains. In addition, CTCF is an important transcription factor and regulator of antigen