Výsledky vyhledávání - "Marjon J, Mourik"

Towards the imaging of Weibel-Palade body biogenesis by serial block face-scanning electron microscopy

Autor: Jeroen Eikenboom, Hans Zimmermann, Abraham J. Koster, Marjon J. Mourik, Frank G. A. Faas

Publikováno v: Journal of Microscopy. 259:97-104

Electron microscopy is used in biological research to study the ultrastructure at high resolution to obtain information on specific cellular processes. Serial block face-scanning electron microscopy is a relatively novel electron microscopy imaging t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::103a419699620e470b58775da5e2afa9
https://doi.org/10.1111/jmi.12222

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Lifecycle of Weibel-Palade bodies

Autor: Marjon J. Mourik, Jeroen Eikenboom

Publikováno v: H�mostaseologie, 37(1), 13-24

SummaryWeibel-Palade bodies (WPBs) are rod or cigar-shaped secretory organelles that are formed by the vascular endothelium. They contain a diverse set of proteins that either function in haemostasis, inflammation, or angiogenesis. Biogenesis of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a67cc7b9bf0c13d61c98c8216c7441
https://hdl.handle.net/1887/115928

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Content delivery to newly forming Weibel-Palade bodies is facilitated by multiple connections with the Golgi apparatus

Autor: Hans Zimmermann, Frank G. A. Faas, Abraham J. Koster, Jan Voorberg, Marjon J. Mourik, Jeroen Eikenboom

Publikováno v: Blood, 125(22), 3509-3516. American Society of Hematology
Blood, 125(22), 3509-3516

Weibel-Palade bodies (WPBs) comprise an on-demand storage organelle within vascular endothelial cells. It's major component, the hemostatic protein von Willebrand factor (VWF), is known to assemble into long helical tubules and is hypothesized to dri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858b2b8aa6a2933ad44029453a8cd2d4
https://hdl.handle.net/1887/102114

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Correlative light microscopy and electron tomography to study Von Willebrand factor exocytosis from vascular endothelial cells

Autor: Marjon J, Mourik, Frank G A, Faas, Karine M, Valentijn, Jack A, Valentijn, Jeroen C, Eikenboom, Abraham J, Koster

Publikováno v: Methods in cell biology. 124

Revealing the ultrastructure and function of fluorescently labeled cellular components by correlative light and electron microscopy (CLEM) facilitates the study of structure-function relationships in complex biological processes. Given the diversity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d80aa66fd4d8d93c56f927d18d94ab3a
https://pubmed.ncbi.nlm.nih.gov/25287837

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Storage and secretion of naturally occurring von Willebrand factor A domain variants

Autor: Jiong-Wei Wang, Karine M. Valentijn, Jan Voorberg, Jeroen Eikenboom, Marjon J. Mourik, Dafna J. Groeneveld, Richard J. Dirven, Pieter H. Reitsma

Publikováno v: British journal of haematology, 167(4), 529-540. Wiley-Blackwell
British Journal of Haematology, 167(4), 529-540
British Journal of Haematology, 167(4), 529-540. Wiley

Von Willebrand disease (VWD) is a bleeding disorder characterized by reduced plasma von Willebrand factor (VWF) levels or functionally abnormal VWF. Low VWF plasma levels in VWD patients are the result of mutations in the VWF gene that lead to decrea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e08b29045607163eeea06854af3ffc
https://pure.amc.nl/en/publications/storage-and-secretion-of-naturally-occurring-von-willebrand-factor-a-domain-variants(af7d5932-d836-4551-adad-bf6d3cbb0665).html

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von Willebrand factor remodeling during exocytosis from vascular endothelial cells

Autor: Jan Voorberg, Jack A. Valentijn, Abraham J. Koster, Karine M. Valentijn, Marjon J. Mourik, Jeroen Eikenboom

Publikováno v: Journal of Thrombosis and Haemostasis, 11(11), 2009-2019
Journal of Thrombosis and Haemostasis, 11(11), 2009-19
Journal of thrombosis and haemostasis, 11(11), 2009-2019. Wiley-Blackwell

Summary Background In vascular endothelial cells, high molecular weight multimers of von Willebrand factor (VWF) are folded into tubular structures for storage in Weibel–Palade bodies. On stimulation, VWF is secreted and forms strings to induce pri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d45d3496a0806414af71a808f5980499
https://hdl.handle.net/1887/102780

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Multigranular exocytosis of Weibel-Palade bodies in vascular endothelial cells

Autor: Gert-Jan Hendriks, Karine M. Valentijn, Tom J. Arends, Abraham J. Koster, Linda F. van Driel, Marjon J. Mourik, Jack A. Valentijn

Publikováno v: Blood, 116(10), 1807-16
Blood, 116(10), 1807-1816

Regulated exocytosis of Weibel-Palade bodies (WPBs) is a pivotal mechanism via which vascular endothelial cells initiate repair in response to injury and inflammation. Several pathways have been proposed to enable differential release of bioactive mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1d52a6fe55a1e3b5d5a2eef472cb67
https://hdl.handle.net/1887/119186

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