Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Marjolijn Renard"'
Autor:
Felke Steijns, Nathalie Bracke, Marjolijn Renard, Julie De Backer, Patrick Sips, Nathan Debunne, Evelien Wynendaele, Frederick Verbeke, Bart De Spiegeleer, Laurence Campens
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Upregulation of the RAS-RAF-MEK-ERK-MAPK pathway is involved in the development of several human tumors, aortic aneurysms, atherosclerosis, and cardiomyopathy. Refametinib, a highly selective MEK-inhibitor, has already shown antineoplastic activity i
Externí odkaz:
https://doaj.org/article/3ef60489e3fc45979fff017a2792931f
Autor:
Felke Steijns, Marjolijn Renard, Marine Vanhomwegen, Petra Vermassen, Jana Desloovere, Robrecht Raedt, Lars E. Larsen, Máté I. Tóth, Julie De Backer, Patrick Sips
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7024 (2020)
Patients with Marfan syndrome (MFS), a connective tissue disorder caused by pathogenic variants in the gene encoding the extracellular matrix protein fibrillin-1, have an increased prevalence of primary cardiomyopathy, arrhythmias, and sudden cardiac
Externí odkaz:
https://doaj.org/article/6bb165e815bc490883a29c246392bfa0
Autor:
Felke Steijns, Máté I. Tóth, Anthony Demolder, Lars E. Larsen, Jana Desloovere, Marjolijn Renard, Robrecht Raedt, Patrick Segers, Julie De Backer, Patrick Sips
Publikováno v:
Sensors, Vol 20, Iss 14, p 3867 (2020)
Ambulatory electrocardiography (AECG) is a primary diagnostic tool in patients with potential arrhythmic disorders. To study the pathophysiological mechanisms of arrhythmic disorders, mouse models are widely implemented. The use of a technique simila
Externí odkaz:
https://doaj.org/article/7a634f7cb2f94679a6bfbd72b4b05cc2
Autor:
Marjolijn Renard, Laura Muiño-Mosquera, Elise C Manalo, Sara Tufa, Eric J Carlson, Douglas R Keene, Julie De Backer, Lynn Y Sakai
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197631 (2018)
[This corrects the article DOI: 10.1371/journal.pone.0181166.].
Externí odkaz:
https://doaj.org/article/15aa6547e3ca471fa061f4c65cf80ebf
Autor:
Marjolijn Renard, Laura Muiño-Mosquera, Elise C Manalo, Sara Tufa, Eric J Carlson, Douglas R Keene, Julie De Backer, Lynn Y Sakai
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181166 (2017)
Sex-related differences as well as the adverse effect of pregnancy on aortic disease outcome are well-established phenomena in humans with Marfan syndrome (MFS). The underlying mechanisms of these observations are largely unknown.In an initial (pilot
Externí odkaz:
https://doaj.org/article/ed35589b5aca43a79652fc94bfb2d5d2
Autor:
Marjolijn Renard, Bram Trachet, Christophe Casteleyn, Laurence Campens, Pieter Cornillie, Bert Callewaert, Steven Deleye, Bert Vandeghinste, Paula M van Heijningen, Harry Dietz, Filip De Vos, Jeroen Essers, Steven Staelens, Patrick Segers, Bart Loeys, Paul Coucke, Anne De Paepe, Julie De Backer
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89749 (2014)
Loeys-Dietz syndrome (LDS) is an autosomal dominant arterial aneurysm disease belonging to the spectrum of transforming growth factor β (TGFβ)-associated vasculopathies. In its most typical form it is characterized by the presence of hypertelorism,
Externí odkaz:
https://doaj.org/article/b75c363598d6443c995fbd08ab7f6f85
Autor:
Olivier Milleron, Marie Paule Jacob, Benoît Ho-Tin-Noé, Marjolijn Renard, Nadine Hanna, Guillaume Jondeau, Laurent Gouya, Marie Sylvie Gross, Sebastien Dupont, Sandy Elbitar, Sébastien Gaertner, Marianne Abifadel, Jeremie Jonquet, Ketty Kessler, Bertrand Isidor, Catherine Boileau, Yves Alembik, Kiyotoshi Sekiguchi, Dianna M. Milewicz, Laurent Tosolini, Mathilde Varret, Mélodie Aubart, Yara Abou Khalil, Youmna Ghaleb, Dongchuan Guo, Jean-Baptiste Michel, Maud Langeois, Louise Benarroch, Ko Tsutsui, Vincenzo Dattilo, Pauline Arnaud, Julie De Backer, Carine Le Goff, Lynn Y. Sakai, Petra El Khoury
Publikováno v:
Genetics in medicine : official journal of the American College of Medical Genetics
GENETICS IN MEDICINE
GENETICS IN MEDICINE
Purpose: Thoracic aortic aneurysm and dissection (TAAD) is a life-threatening disease with often unrecognized inherited forms. We sought to identify novel pathogenic variants associated with autosomal dominant inheritance of TAAD. Methods: We analyze
Autor:
Josephina A.N. Meester, Silke Peeters, Lotte Van Den Heuvel, Geert Vandeweyer, Erik Fransen, Elizabeth Cappella, Harry C. Dietz, Geoffrey Forbus, Bruce D. Gelb, Elizabeth Goldmuntz, Arvind Hoskoppal, Andrew P. Landstrom, Teresa Lee, Seema Mital, Shaine Morris, Aaron K. Olson, Marjolijn Renard, Dan M. Roden, Michael N. Singh, Elif Seda Selamet Tierney, Justin T. Tretter, Sara L. Van Driest, Marcia Willing, Aline Verstraeten, Lut Van Laer, Ronald V. Lacro, Bart L. Loeys
Publikováno v:
Genetics in medicine
Genetics in Medicine, 24, 1045-1053
Genetics in Medicine, 24, 5, pp. 1045-1053
Genetics in Medicine, 24, 1045-1053
Genetics in Medicine, 24, 5, pp. 1045-1053
PURPOSE In a large cohort of 373 pediatric patients with Marfan syndrome (MFS) with a severe cardiovascular phenotype, we explored the proportion of patients with MFS with a pathogenic FBN1 variant and analyzed whether the type/location of FBN1 varia
Autor:
Joyce Burger, Ingrid van der Pluijm, Andy Willaert, Marjolijn Renard, Sander Barnhoorn, Bert Callewaert, Marine Vanhomwegen, Annekatrien Boel, Benedicte Descamps, Christian Vanhove, Paul Coucke, Jeroen Essers, Christophe Casteleyn, Aude Beyens, Dieter P. Reinhardt
Publikováno v:
Human Molecular Genetics, 29(9), 1476-1488. Oxford University Press
Arterial tortuosity syndrome (ATS) is a recessively inherited connective tissue disorder, mainly characterized by tortuosity and aneurysm formation of the major arteries. ATS is caused by loss-of-function mutations in SLC2A10, encoding the facilitati
Autor:
Angela M. Sharkey, Jami C. Levine, Bruce D. Gelb, Arvind Hoskoppal, Sara L. Van Driest, Jonathan D. Mosley, Jennifer S. Li, Christian M. Shaffer, Elizabeth Goldmuntz, Dan M. Roden, Shaine A. Morris, Bart Loeys, Josephina A.N. Meester, Larry W. Markham, Harry C. Dietz, Marjolijn Renard, Seema Mital, Geoffrey A. Forbus, Ronald V. Lacro, Jeanne James, Aaron K Olson, Teresa M. Lee, Luciana Young, Lynn A. Sleeper
Publikováno v:
J Pediatr
The journal of pediatrics
The journal of pediatrics
Objective To test whether variants in ADRB1 and CYP2C9 genes identify subgroups of individuals with differential response to treatment for Marfan syndrome through analysis of data from a large, randomized trial. Study design In a subset of 250 white,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f9079548145fb25ea7610d872b36fa8
https://europepmc.org/articles/PMC7323908/
https://europepmc.org/articles/PMC7323908/