Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Marjolein van Sluis"'
Autor:
Camila Gonzalo Hansen, Barbara Steurer, Roel C. Janssens, Di Zhou, Marjolein van Sluis, Hannes Lans, Jurgen A. Marteijn
Faithful transcription of eukaryotic genes by RNA polymerase II (Pol II) is essential for proper cell function. Nevertheless, the integrity of the DNA template of Pol II is continuously challenged by different sources of DNA damage, such as UV-light,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efe7c6942307ee50f041d7ec3a13a255
https://doi.org/10.1101/2023.05.17.541110
https://doi.org/10.1101/2023.05.17.541110
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance A detailed description of how the genome is organized within the human nucleus is a major research goal. Nucleolar organizer regions (NORs) comprising ribosomal DNA (rDNA) arrays are located on the p-arms of the five human acrocentric ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b62d65b94229c9854042a1c00dcbb8
https://doi.org/10.1073/pnas.2001812117
https://doi.org/10.1073/pnas.2001812117
Autor:
Joseph G.W. McCarter, Hazel Mangan, Marjolein van Sluis, Alice Grob, Brian McStay, Michael Ó Gailín
Publikováno v:
Genes Dev
Human nucleolar organizer regions (NORs), containing ribosomal gene (rDNA) arrays, are located on the p-arms of acrocentric chromosomes (HSA13–15, 21, and 22). Absence of these p-arms from genome references has hampered research on nucleolar format
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd73e9540621c6505cbd5d62210fab32
https://doi.org/10.1101/gad.331892.119
https://doi.org/10.1101/gad.331892.119
Autor:
Brian McStay, Marjolein van Sluis
Publikováno v:
Current Opinion in Cell Biology. 46:81-86
Nucleoli, sites of ribosome biogenesis, form around nucleolar organizer regions (NORs) comprising rDNA arrays, located on human acrocentric chromosome p-arms. NORs provide an opportunity to investigate the DNA double strand break (DSB) response at hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bfcf756ab4850ab96a9f69af9fb104b
https://doi.org/10.1016/j.ceb.2017.03.004
https://doi.org/10.1016/j.ceb.2017.03.004
Autor:
Marjolein van Sluis, Brian McStay
Publikováno v:
Trends in genetics : TIG. 35(10)
Nucleoli, the sites of ribosome biogenesis, form around ribosomal gene (rDNA) arrays termed nucleolar organiser regions (NORs). These are the most transcriptionally active regions of the human genome and specialised responses have evolved to ensure t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f8c44453a31635bd53f6a99bee318d
https://pubmed.ncbi.nlm.nih.gov/31353047
https://pubmed.ncbi.nlm.nih.gov/31353047
Autor:
Marjolein van Sluis, Brian McStay
Publikováno v:
Genes & Development. 29:1151-1163
DNA double-strand breaks (DSBs) are repaired by two main pathways: nonhomologous end-joining and homologous recombination (HR). Repair pathway choice is thought to be determined by cell cycle timing and chromatin context. Nucleoli, prominent nuclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8df4b5f6fb36cca175ec111239159c9
https://doi.org/10.1101/gad.260703.115
https://doi.org/10.1101/gad.260703.115
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1455
3D-immunoFISH is a valuable technique to compare the localization of DNA sequences and proteins in cells where three-dimensional structure has been preserved. As nucleoli contain a multitude of protein factors dedicated to ribosome biogenesis and for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::90af8d96a4e94da601087afe2ab50f05
https://pubmed.ncbi.nlm.nih.gov/27576706
https://pubmed.ncbi.nlm.nih.gov/27576706
Publikováno v:
The Nucleolus ISBN: 9781493937905
3D-immunoFISH is a valuable technique to compare the localization of DNA sequences and proteins in cells where three-dimensional structure has been preserved. As nucleoli contain a multitude of protein factors dedicated to ribosome biogenesis and for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b71cbc7b3eb857645c2ab7391a6a0a70
https://doi.org/10.1007/978-1-4939-3792-9_1
https://doi.org/10.1007/978-1-4939-3792-9_1
Autor:
Marjolein van Sluis, Brian McStay
Publikováno v:
Oncotarget
DNA double strand breaks (DSBs) are the most dangerous form of DNA damage and need to be repaired efficiently in order to maintain genomic stability. The kinase ATM becomes activated upon recognition of DSBs and transduces this into cell cycle checkp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9da01934da00fb9a4fc0c3b5b6641531
https://doi.org/10.18632/oncotarget.4840
https://doi.org/10.18632/oncotarget.4840