Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Marjolein V. Smith"'
Publikováno v:
Birth defects researchREFERENCES.
When analyzing fetal defect incidence in laboratory animal studies, correlation in responses within litters (i.e., litter effects) can lead to increased false-positive rates if litter effects are not incorporated into the analysis. Studies of fetal d
Autor:
Marjolein V Smith, Windy A Boyd, Grace E Kissling, Julie R Rice, Daniel W Snyder, Christopher J Portier, Jonathan H Freedman
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7018 (2009)
BackgroundAs part of a program to predict the toxicity of environmental agents on human health using alternative methods, several in vivo high- and medium-throughput assays are being developed that use C. elegans as a model organism. C. elegans-based
Externí odkaz:
https://doaj.org/article/7892633e1bee45909a6b29195d308452
Autor:
Windy A Boyd, Marjolein V Smith, Grace E Kissling, Julie R Rice, Daniel W Snyder, Christopher J Portier, Jonathan H Freedman
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7024 (2009)
BackgroundThe nematode Caenorhabditis elegans is being assessed as an alternative model organism as part of an interagency effort to develop better means to test potentially toxic substances. As part of this effort, assays that use the COPAS Biosort
Externí odkaz:
https://doaj.org/article/192ef83a96db412682bed36d6e68fc24
Autor:
Caroll A. Co, Windy A. Boyd, Jason R. Pirone, Jonathan H. Freedman, Marjolein V. Smith, Julie R. Rice, Keith R. Shockley
Publikováno v:
Environmental Health Perspectives
Background: Modern toxicology is shifting from an observational to a mechanistic science. As part of this shift, high-throughput toxicity assays are being developed using alternative, nonmammalian species to prioritize chemicals and develop predictio
Autor:
Windy A. Boyd, Jinghua Zhao, Christopher P. Austin, Russell S. Thomas, Keith A. Houck, Pei-Hsuan Chu, Matthew F. Bridge, Julie R. Rice, Kristine L. Witt, Raymond R. Tice, Jonathan H. Freedman, Amber J. Hackstadt, Menghang Xia, Marjolein V. Smith, Sheng Dai, Michael J. DeVito, Qiang Shi, Paul E Dunlap, Richard S. Paules, Anton Simeonov, David Gerhold, Wei Zheng, Nuo Sun, Ruili Huang
Publikováno v:
Environmental Health Perspectives
Background: A central challenge in toxicity testing is the large number of chemicals in commerce that lack toxicological assessment. In response, the Tox21 program is re-focusing toxicity testing from animal studies to less expensive and higher throu
Autor:
Dave Chandra, Jonathan H. Freedman, Julie R. Rice, Pamela K. Den Besten, Windy A. Boyd, Marjolein V. Smith
Publikováno v:
Environmental Toxicology and Chemistry. 33:82-88
Fluorides are commonly added to drinking water in the United States to decrease the incidence of dental caries. Silicofluorides, such as sodium hexafluorosilicate (Na2 SiF6 ) and fluorosilicic acid (H2 SiF6 ), are mainly used for fluoridation, althou
Autor:
Judy Strickland, Marjolein V. Smith, Richard W Morris, Joanna Jaworska, Yuri Dancik, Lori Rinckel, Thomas A Burns, Nicole Kleinstreuer, Warren Casey, Jason R. Pirone
Publikováno v:
ALTEX. 31(3)
An open-source implementation of a previously published integrated testing strategy (ITS) for skin sensitization using a Bayesian network has been developed using R, a free and open-source statistical computing language. The ITS model provides probab
Publikováno v:
BMC Genomics
Background Mercury is a ubiquitous environmental toxicant that exists in multiple chemical forms. A paucity of information exists regarding the differences or similarities by which different mercurials act at the molecular level. Results Transcriptom
Autor:
Julie R, Rice, Windy A, Boyd, Dave, Chandra, Marjolein V, Smith, Pamela K, Den Besten, Jonathan H, Freedman
Publikováno v:
Environmental toxicology and chemistry. 33(1)
Fluorides are commonly added to drinking water in the United States to decrease the incidence of dental caries. Silicofluorides, such as sodium hexafluorosilicate (Na2 SiF6 ) and fluorosilicic acid (H2 SiF6 ), are mainly used for fluoridation, althou
Publikováno v:
Methods in Molecular Biology ISBN: 9781617798665
A number of practical advantages have made the nematode Caenorhabditis elegans a useful model for genetic and developmental biological research. These same advantages, along with conservation of disease and stress response pathways, availability of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e2b7671902395a5b8971c1545ccf6d8
https://doi.org/10.1007/978-1-61779-867-2_3
https://doi.org/10.1007/978-1-61779-867-2_3