Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Marjolein Sluijter"'
Autor:
Jim Middelburg, Marjolein Sluijter, Gaby Schaap, Büşra Göynük, Katy Lloyd, Vitalijs Ovcinnikovs, Gijs G. Zom, Renoud J. Marijnissen, Christianne Groeneveldt, Lisa Griffioen, Gerwin G. W. Sandker, Sandra Heskamp, Sjoerd H. van der Burg, Tsolere Arakelian, Ferry Ossendorp, Ramon Arens, Janine Schuurman, Kristel Kemper, Thorbald van Hall
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract CD3 bispecific antibody (CD3 bsAb) therapy is clinically approved for refractory hematological malignancies, but responses in solid tumors have been limited so far. One of the main hurdles in solid tumors is the lack of sufficient T-cell inf
Externí odkaz:
https://doaj.org/article/36795cab2cda485e96053669065dc63a
Autor:
Jim Middelburg, Soroush Ghaffari, Tom A.W. Schoufour, Marjolein Sluijter, Gaby Schaap, Büsra Göynük, Benedetta M. Sala, Lejla Al-Tamimi, Ferenc Scheeren, Kees L.M.C. Franken, Jimmy J.L.L. Akkermans, Birol Cabukusta, Simone A. Joosten, Ian Derksen, Jacques Neefjes, Sjoerd H. van der Burg, Adnane Achour, Ruud H.M. Wijdeven, Jon Weidanz, Thorbald van Hall
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113516- (2023)
Summary: The immune checkpoint NKG2A/CD94 is a promising target for cancer immunotherapy, and its ligand major histocompatibility complex E (MHC-E) is frequently upregulated in cancer. NKG2A/CD94-mediated inhibition of lymphocytes depends on the pres
Externí odkaz:
https://doaj.org/article/380d9d0a2508416bb76695633b6aeefe
Autor:
Yixin Luo, Maarten H. Vermeer, Frank R. de Gruijl, Willem H. Zoutman, Marjolein Sluijter, Thorbald van Hall, Cornelis P. Tensen
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
IntroductionMycosis fungoides (MF), the most common type of Cutaneous T cell Lymphoma (CTCL), is characterized by an inflamed skin intermixed with proliferating malignant mature skin-homing CD4+ T cells. Detailed genomic analyses of MF skin biopsies
Externí odkaz:
https://doaj.org/article/a9c3b8f9ce1e4ade8c292c714046e8f5
Autor:
Rob C Hoeben, Sjoerd H van der Burg, Marjolein Sluijter, Thorbald van Hall, Joke M M Den Haan, Camilla Labrie, Christianne Groeneveldt, Priscilla Kinderman, Diana J M van den Wollenberg, Nadine van Montfoort, Lisa Griffioen, Jordi J C van Stigt Thans
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)
Background Many solid tumors do not respond to immunotherapy due to their immunologically cold tumor microenvironment (TME). We and others found that oncolytic viruses (OVs), including reovirus type 3 Dearing, can enhance the efficacy of immunotherap
Externí odkaz:
https://doaj.org/article/3366d822d5c7405c92a4c4b02eb41013
Autor:
Koen A. Marijt, Marjolein Sluijter, Laura Blijleven, Sofie H. Tolmeijer, Ferenc A. Scheeren, Sjoerd H. van der Burg, Thorbald van Hall
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-12 (2019)
Abstract Background T-cell mediated immunotherapy brought clinical success for many cancer patients. Nonetheless, downregulation of MHC class I antigen presentation, frequently occurring in solid cancers, limits the efficacy of these therapies. Unrav
Externí odkaz:
https://doaj.org/article/85c217c823ff441f83eae360b029fc7a
Autor:
Xiaoli Wang, Sytse J Piersma, Christopher A Nelson, Ya-Nan Dai, Ted Christensen, Eric Lazear, Liping Yang, Marjolein Sluijter, Thorbald van Hall, Ted H Hansen, Wayne M Yokoyama, Daved H Fremont
Publikováno v:
eLife, Vol 7 (2018)
A recurrent theme in viral immune evasion is the sabotage of MHC-I antigen presentation, which brings virus the concomitant issue of ‘missing-self’ recognition by NK cells that use inhibitory receptors to detect surface MHC-I proteins. Here, we r
Externí odkaz:
https://doaj.org/article/c9672d426e5e45eca7a97f1415a0cf7e
Autor:
Elien M. Doorduijn, Marjolein Sluijter, Koen A. Marijt, Bianca J. Querido, Sjoerd H. van der Burg, Thorbald van Hall
Publikováno v:
OncoImmunology, Vol 7, Iss 3 (2018)
Cancers frequently evade immune-recognition by lowering peptide:MHC-I complexes on their cell surface. Limited peptide supply due to TAP-deficiency results in such MHC-Ilow immune-escape variants. Previously, we reported on a category of TAP-independ
Externí odkaz:
https://doaj.org/article/c2e0ac7b3d434c328ea6ff06848bbc5a
Autor:
Elien M. Doorduijn, Marjolein Sluijter, Bianca J. Querido, Ursula J. E. Seidel, Claudia C. Oliveira, Sjoerd H. van der Burg, Thorbald van Hall
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The HLA-E homolog in the mouse (Qa-1b) is a conserved MHC class Ib molecule presenting monomorphic peptides to germline-encoded natural killer receptor CD94/NKG2A. Previously, we demonstrated the replacement of this canonical peptide by a diverse pep
Externí odkaz:
https://doaj.org/article/ebc3efef40334db0ab6665b07b3054ce
Autor:
Marjolein Sluijter, Tetje C van der Sluis, Pieter A van der Velden, Mieke Versluis, Brian L West, Sjoerd H van der Burg, Thorbald van Hall
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104230 (2014)
Tumor associated macrophages (TAM) can promote angiogenesis, invasiveness and immunosuppression. The cytokine CSF-1 (or M-CSF) is an important factor of TAM recruitment and differentiation and several pharmacological agents targeting the CSF-1 recept
Externí odkaz:
https://doaj.org/article/7debb9974bab4a178db9a4770e294bd7
Autor:
Xiao-Lin Li, Marjolein Sluijter, Elien M Doorduijn, Shubha P Kale, Harris McFerrin, Yong-Yu Liu, Yan Li, Madhusoodanan Mottamal, Xin Yao, Fengkun Du, Baihan Gu, Kim Hoang, Yen H Nguyen, Nichelle Taylor, Chelsea R Stephens, Thorbald van Hall, Qian-Jin Zhang
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e108192 (2014)
The association of B7-1/CD28 between antigen presenting cells (APCs) and T-cells provides a second signal to proliferate and activate T-cell immunity at the induction phase. Many reports indicate that tumor cells transfected with B7-1 induced augment
Externí odkaz:
https://doaj.org/article/f19ef3458ca444f3bfe66781882d6c97