BMP7 reduces the fibrocartilage chondrocyte phenotype

Autor: Ellen G. J. Ripmeester, Marjolein M. J. Caron, Guus G. H. van den Akker, Jessica Steijns, Don A. M. Surtel, Andy Cremers, Laura C. W. Peeters, Lodewijk W. van Rhijn, Tim J. M. Welting

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract The fibrocartilage chondrocyte phenotype has been recognized to attribute to osteoarthritis (OA) development. These chondrocytes express genes related to unfavorable OA outcomes, emphasizing its importance in OA pathology. BMP7 is being expl

Externí odkaz: https://doaj.org/article/01cfdb8fb7d54afe8a50c8e5b9da0ebe

Sox9 Determines Translational Capacity During Early Chondrogenic Differentiation of ATDC5 Cells by Regulating Expression of Ribosome Biogenesis Factors and Ribosomal Proteins

Autor: Marjolein M. J. Caron, Maxime Eveque, Berta Cillero-Pastor, Ron M. A. Heeren, Bas Housmans, Kasper Derks, Andy Cremers, Mandy J. Peffers, Lodewijk W. van Rhijn, Guus van den Akker, Tim J. M. Welting

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

IntroductionIn addition to the well-known cartilage extracellular matrix-related expression of Sox9, we demonstrated that chondrogenic differentiation of progenitor cells is driven by a sharply defined bi-phasic expression of Sox9: an immediate early

Externí odkaz: https://doaj.org/article/29467c415e404b3c97d0e75e58695b9e

Expression of RMRP RNA is regulated in chondrocyte hypertrophy and determines chondrogenic differentiation

Autor: Mandy M. F. Steinbusch, Marjolein M. J. Caron, Don A. M. Surtel, Franziska Friedrich, Ekkehart Lausch, Ger J. M. Pruijn, Wouter Verhesen, Blanche L. M. Schroen, Lodewijk W. van Rhijn, Bernhard Zabel, Tim J. M. Welting

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)

Abstract Mutations in the RMRP-gene, encoding the lncRNA component of the RNase MRP complex, are the origin of cartilage-hair hypoplasia. Cartilage-hair hypoplasia is associated with severe dwarfism caused by impaired skeletal development. However, i

Externí odkaz: https://doaj.org/article/fe524fe2574a400f80a3473252df828a

Combining phosphate binder therapy with vitamin K2 inhibits vascular calcification in an experimental animal model of kidney failure

Autor: Rafael Kramann, Marjolein M. J. Caron, Bert van Rietbergen, Peter Leenders, Selene Prisco, Jürgen Floege, Tim J. M. Welting, Marc G. Vervloet, Grzegorz B. Wasilewski, Leon J. Schurgers, Aegida Neradova

Publikováno v: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association-European Renal Association, 37(4), 652-662. Oxford University Press
Nephrology Dialysis Transplantation, 37(4), 652-662. Oxford University Press
Neradova, A, Wasilewski, G, Prisco, S, Leenders, P, Caron, M, Welting, T, van Rietbergen, B, Kramann, R, Floege, J R, Vervloet, M G & Schurgers, L J 2022, ' Combining phosphate binder therapy with vitamin K2 inhibits vascular calcification in an experimental animal model of kidney failure ', Nephrology Dialysis Transplantation, vol. 37, no. 4, pp. 652-662 . https://doi.org/10.1093/ndt/gfab314

Background Hyperphosphataemia is strongly associated with cardiovascular disease and mortality. Recently, phosphate binders (PBs), which are used to bind intestinal phosphate, have been shown to bind vitamin K, thereby potentially aggravating vitamin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9625b857ce9e8b9c9488405248968ad1
https://doi.org/10.1093/ndt/gfab314

The Role of Prostaglandins and COX-Enzymes in Chondrogenic Differentiation of ATDC5 Progenitor Cells.

Autor: Marjolein M J Caron, Pieter J Emans, Kathleen Sanen, Don A M Surtel, Andy Cremers, Daan Ophelders, Lodewijk W van Rhijn, Tim J M Welting

Publikováno v: PLoS ONE, Vol 11, Iss 4, p e0153162 (2016)

NSAIDs are used to relieve pain and decrease inflammation by inhibition of cyclooxygenase (COX)-catalyzed prostaglandin (PG) synthesis. PGs are fatty acid mediators involved in cartilage homeostasis, however the action of their synthesizing COX-enzym

Externí odkaz: https://doaj.org/article/1a2e8a97ef1042ffbace493ca6afa60f