Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Marjolein M. J. Caron"'
Autor:
Guus G. H. van den Akker, Alzbeta Chabronova, Bas A. C. Housmans, Laura van der Vloet, Don A. M. Surtel, Andy Cremers, Virginie Marchand, Yuri Motorin, Marjolein M. J. Caron, Mandy J. Peffers, Tim J. M. Welting
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 5031 (2024)
Alterations in cell fate are often attributed to (epigenetic) regulation of gene expression. An emerging paradigm focuses on specialized ribosomes within a cell. However, little evidence exists for the dynamic regulation of ribosome composition and f
Externí odkaz:
https://doaj.org/article/d7d9f5d831d74ac3ad9db64e42e3112d
Autor:
Alzbeta Chabronova, Guus van den Akker, Bas A. C. Housmans, Marjolein M. J. Caron, Andy Cremers, Don A. M. Surtel, Mandy J. Peffers, Lodewijk W. van Rhijn, Virginie Marchand, Yuri Motorin, Tim J. M. Welting
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12578 (2023)
Eukaryotic ribosomes are complex molecular nanomachines translating genetic information from mRNAs into proteins. There is natural heterogeneity in ribosome composition. The pseudouridylation (ψ) of ribosomal RNAs (rRNAs) is one of the key sources o
Externí odkaz:
https://doaj.org/article/f79530137c2145ee8eaffd0161a54d5d
Autor:
Ellen G. J. Ripmeester, Marjolein M. J. Caron, Guus G. H. van den Akker, Jessica Steijns, Don A. M. Surtel, Andy Cremers, Laura C. W. Peeters, Lodewijk W. van Rhijn, Tim J. M. Welting
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The fibrocartilage chondrocyte phenotype has been recognized to attribute to osteoarthritis (OA) development. These chondrocytes express genes related to unfavorable OA outcomes, emphasizing its importance in OA pathology. BMP7 is being expl
Externí odkaz:
https://doaj.org/article/01cfdb8fb7d54afe8a50c8e5b9da0ebe
Autor:
Ellen G. J. Ripmeester, Tim J. M. Welting, Guus G. H. van den Akker, Don A. M. Surtel, Jessica S. J. Steijns, Andy Cremers, Lodewijk W. van Rhijn, Marjolein M. J. Caron
Publikováno v:
PLoS ONE, Vol 17, Iss 2 (2022)
BMP7 is a morphogen capable of counteracting the OA chondrocyte hypertrophic phenotype via NKX3-2. NKX3-2 represses expression of RUNX2, an important transcription factor for chondrocyte hypertrophy. Since RUNX2 has previously been described as an in
Externí odkaz:
https://doaj.org/article/68066cf15959463cbf6882b07c7b2fb3
Autor:
Marjolein M. J. Caron, Maxime Eveque, Berta Cillero-Pastor, Ron M. A. Heeren, Bas Housmans, Kasper Derks, Andy Cremers, Mandy J. Peffers, Lodewijk W. van Rhijn, Guus van den Akker, Tim J. M. Welting
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
IntroductionIn addition to the well-known cartilage extracellular matrix-related expression of Sox9, we demonstrated that chondrogenic differentiation of progenitor cells is driven by a sharply defined bi-phasic expression of Sox9: an immediate early
Externí odkaz:
https://doaj.org/article/29467c415e404b3c97d0e75e58695b9e
Autor:
Marjolein M. J. Caron, Maarten P. F. Janssen, Laura Peeters, Dominik R. Haudenschild, Andy Cremers, Don A. M. Surtel, Lodewijk W. van Rhijn, Pieter J. Emans, Tim J. M. Welting
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
The generation of cartilage from progenitor cells for the purpose of cartilage repair is often hampered by hypertrophic differentiation of the engineered cartilaginous tissue caused by endochondral ossification. Since a healthy cartilage matrix conta
Externí odkaz:
https://doaj.org/article/36dffda142384c068a95fe5f22f5ffe5
Autor:
Mandy M. F. Steinbusch, Marjolein M. J. Caron, Don A. M. Surtel, Franziska Friedrich, Ekkehart Lausch, Ger J. M. Pruijn, Wouter Verhesen, Blanche L. M. Schroen, Lodewijk W. van Rhijn, Bernhard Zabel, Tim J. M. Welting
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Mutations in the RMRP-gene, encoding the lncRNA component of the RNase MRP complex, are the origin of cartilage-hair hypoplasia. Cartilage-hair hypoplasia is associated with severe dwarfism caused by impaired skeletal development. However, i
Externí odkaz:
https://doaj.org/article/fe524fe2574a400f80a3473252df828a
Autor:
Ufuk Tan Timur, Marjolein M. J. Caron, Ralph M. Jeuken, Yvonne M. Bastiaansen-Jenniskens, Tim J. M. Welting, Lodewijk W. van Rhijn, Gerjo J. V. M. van Osch, Pieter J. Emans
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 18, p 6962 (2020)
Knee osteoarthritis (OA) is a condition mainly characterized by cartilage degradation. Currently, no effective treatment exists to slow down the progression of OA-related cartilage damage. Selective COX-2 inhibitors may, next to their pain killing pr
Externí odkaz:
https://doaj.org/article/63e94c5d40ce4da8a5c2c02cd3773e8e
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 6 (2018)
Osteoarthritis (OA) is an extremely prevalent age-related condition. The economic and societal burden due to the cost of symptomatic treatment, inability to work, joint replacement, and rehabilitation is huge and increasing. Currently, there are no e
Externí odkaz:
https://doaj.org/article/ad19bfdac9ee4d4eb31fd20e92c0d80b
Autor:
Rafael Kramann, Marjolein M. J. Caron, Bert van Rietbergen, Peter Leenders, Selene Prisco, Jürgen Floege, Tim J. M. Welting, Marc G. Vervloet, Grzegorz B. Wasilewski, Leon J. Schurgers, Aegida Neradova
Publikováno v:
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association-European Renal Association, 37(4), 652-662. Oxford University Press
Nephrology Dialysis Transplantation, 37(4), 652-662. Oxford University Press
Neradova, A, Wasilewski, G, Prisco, S, Leenders, P, Caron, M, Welting, T, van Rietbergen, B, Kramann, R, Floege, J R, Vervloet, M G & Schurgers, L J 2022, ' Combining phosphate binder therapy with vitamin K2 inhibits vascular calcification in an experimental animal model of kidney failure ', Nephrology Dialysis Transplantation, vol. 37, no. 4, pp. 652-662 . https://doi.org/10.1093/ndt/gfab314
Nephrology Dialysis Transplantation, 37(4), 652-662. Oxford University Press
Neradova, A, Wasilewski, G, Prisco, S, Leenders, P, Caron, M, Welting, T, van Rietbergen, B, Kramann, R, Floege, J R, Vervloet, M G & Schurgers, L J 2022, ' Combining phosphate binder therapy with vitamin K2 inhibits vascular calcification in an experimental animal model of kidney failure ', Nephrology Dialysis Transplantation, vol. 37, no. 4, pp. 652-662 . https://doi.org/10.1093/ndt/gfab314
Background Hyperphosphataemia is strongly associated with cardiovascular disease and mortality. Recently, phosphate binders (PBs), which are used to bind intestinal phosphate, have been shown to bind vitamin K, thereby potentially aggravating vitamin