A meta-analysis of gene expression signatures of blood pressure and hypertension.

Autor: Tianxiao Huan, Tõnu Esko, Marjolein J Peters, Luke C Pilling, Katharina Schramm, Claudia Schurmann, Brian H Chen, Chunyu Liu, Roby Joehanes, Andrew D Johnson, Chen Yao, Sai-Xia Ying, Paul Courchesne, Lili Milani, Nalini Raghavachari, Richard Wang, Poching Liu, Eva Reinmaa, Abbas Dehghan, Albert Hofman, André G Uitterlinden, Dena G Hernandez, Stefania Bandinelli, Andrew Singleton, David Melzer, Andres Metspalu, Maren Carstensen, Harald Grallert, Christian Herder, Thomas Meitinger, Annette Peters, Michael Roden, Melanie Waldenberger, Marcus Dörr, Stephan B Felix, Tanja Zeller, International Consortium for Blood Pressure GWAS (ICBP), Ramachandran Vasan, Christopher J O'Donnell, Peter J Munson, Xia Yang, Holger Prokisch, Uwe Völker, Joyce B J van Meurs, Luigi Ferrucci, Daniel Levy

Publikováno v: PLoS Genetics, Vol 11, Iss 3, p e1005035 (2015)

Genome-wide association studies (GWAS) have uncovered numerous genetic variants (SNPs) that are associated with blood pressure (BP). Genetic variants may lead to BP changes by acting on intermediate molecular phenotypes such as coded protein sequence

Externí odkaz: https://doaj.org/article/f8560d082fc3446faee8ddcbcfa995fc

Associations of carotid intima media thickness with gene expression in whole blood and genetically predicted gene expression across 48 tissues

Autor: Joshua C. Bis, Holger Kirsten, Wolfgang Rathmann, Albert Hofman, Shih-Jen Hwang, Stefan Weiss, Annette Peters, Oscar H. Franco, Klodian Dhana, Brenda W J H Penninx, Katharina Schramm, Christian Herder, Joseph F. Polak, Adrie Seldenrijk, Wolfgang Koenig, Markus Loeffler, Marcus Dörr, Andy B Castaneda, Petra Wolf, Frank Beutner, Christopher J. O’Donnell, Xiaoling Zhang, Jochen Seissler, Christa Meisinger, Joachim Thiery, Holger Prokisch, Rick Jansen, Joyce B. J. van Meurs, André G. Uitterlinden, Nora Franceshini, Jennifer E. Below, Georg Homuth, Paul S. de Vries, Daniel Levy, Marjolein J. Peters, Cohorts for Heart, Gerard van Grootheest, Abbas Dehghan, Markus Scholz, Ulf Schminke, Carola Marzi, Melanie Waldenberger, Knut Krohn, Claudia Giambartolomei, Lauren E. Petty, Maryam Kavousi, Henry Völzke

Publikováno v: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Subclinical Working Group 2022, ' Associations of carotid intima media thickness with gene expression in whole blood and genetically predicted gene expression across 48 tissues ', Human Molecular Genetics, vol. 31, no. 7, pp. 1171-1182 . https://doi.org/10.1093/hmg/ddab236, https://doi.org/10.1093/hmg/ddab236
Human Molecular Genetics, 31(7), 1171-1182. Oxford University Press
Hum Mol Genet

Carotid intima media thickness (cIMT) is a biomarker of subclinical atherosclerosis and a predictor of future cardiovascular events. Identifying associations between gene expression levels and cIMT may provide insight to atherosclerosis etiology. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61fc58ef9e80951689e00a99b96d510b
https://pure.eur.nl/en/publications/d15b4fdb-5cf3-402f-9f22-00ca24fa6759

An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis

Autor: Jennifer A. Smith, Andrea A. Baccarelli, Jordana T. Bell, James B. Meigs, James S. Pankow, Jun Liu, Ayse Demirkan, Marjolein J. Peters, Jerome I. Rotter, Elias Salfati, Bertha Hidalgo, Audrey Y. Chu, André G. Uitterlinden, Luigi Ferrucci, Pooja R. Mandaviya, Nona Sotoodehnia, Eric A. Whitsel, Liesbeth Duijts, Marie-France Hivert, Elena Carnero-Montoro, Eric J.G. Sijbrands, Ann Zenobia Moore, Janine F. Felix, Jenny van Dongen, Najaf Amin, Tim D. Spector, Oscar H. Franco, Harald Grallert, Tiphaine Martin, Ivana Nedeljkovic, Josée Dupuis, Aaron Isaacs, Themistocles L. Assimes, Pei-Chien Tsai, Cornelia M. van Duijn, Lifang Hou, Daniel Levy, Ko Willems van Dijk, Rahul Gondalia, Samantha Lent, Abbas Dehghan, Rozenn N. Lemaitre, Jan Bressler, Christian Herder, Min A. Jhun, Symen Ligthart, Dorret I. Boomsma, Gonneke Willemsen, Toshiko Tanaka, Rick Jansen, Joyce B. J. van Meurs, Shih-Jen Hwang, Vincent W. V. Jaddoe, Donna K. Arnett, Eco J. C. de Geus, Henning Tiemeier, Stefania Bandinelli

Publikováno v: Liu, Jun; Carnero-Montoro, Elena; van Dongen, Jenny; Lent, Samantha; Nedeljkovic, Ivana; Ligthart, Symen; Tsai, Pei-Chien; Martin, Tiphaine C; Mandaviya, Pooja R; Jansen, Rick; Peters, Marjolein J; Duijts, Liesbeth; Jaddoe, Vincent W V; Tiemeier, Henning; Felix, Janine F; Willemsen, Gonneke; de Geus, Eco J C; Chu, Audrey Y; Levy, Daniel; Hwang, Shih-Jen; ... (2019). An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis. Nature communications, 10(1), p. 2581. Nature Publishing Group 10.1038/s41467-019-10487-4
Nature Communications, 10(1):2581. Nature Publishing Group
Liu, J, Carnero-Montoro, E, van Dongen, J, Lent, S, Nedeljkovic, I, Ligthart, S, Tsai, P-C, Martin, T C, Mandaviya, P R, Jansen, R, Peters, M J, Duijts, L, Jaddoe, V W V, Tiemeier, H, Felix, J F, Willemsen, G, de Geus, E J C, Chu, A Y, Levy, D, Hwang, S-J, Bressler, J, Gondalia, R, Salfati, E L, Herder, C, Hidalgo, B A, Tanaka, T, Moore, A Z, Lemaitre, R N, Jhun, M A, Smith, J A, Sotoodehnia, N, Bandinelli, S, Ferrucci, L, Arnett, D K, Grallert, H, Assimes, T L, Hou, L, Baccarelli, A, Whitsel, E A, van Dijk, K W, Amin, N, Uitterlinden, A G, Sijbrands, E J G, Franco, O H, Dehghan, A, Spector, T D, Dupuis, J, Hivert, M-F, Rotter, J I, Meigs, J B, Pankow, J S, van Meurs, J B J, Isaacs, A, Boomsma, D I, Bell, J T, Demirkan, A & van Duijn, C M 2019, ' An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis ', Nature Communications, vol. 10, no. 1, 2581, pp. 2581 . https://doi.org/10.1038/s41467-019-10487-4
Nature Communications, 10. NATURE PUBLISHING GROUP
Nature Communications, 10:2581. Nature Publishing Group
Liu, J, Carnero-Montoro, E, van Dongen, J, Lent, S, Nedeljkovic, I, Ligthart, S, Tsai, P C, Martin, T C, Mandaviya, P R, Jansen, R, Peters, M J, Duijts, L, Jaddoe, V W V, Tiemeier, H, Felix, J F, Willemsen, G, de Geus, E J C, Chu, A Y, Levy, D, Hwang, S J, Bressler, J, Gondalia, R, Salfati, E L, Herder, C, Hidalgo, B A, Tanaka, T, Moore, A Z, Lemaitre, R N, Jhun, M A, Smith, J A, Sotoodehnia, N, Bandinelli, S, Ferrucci, L, Arnett, D K, Grallert, H, Assimes, T L, Hou, L, Baccarelli, A, Whitsel, E A, van Dijk, K W, Amin, N, Uitterlinden, A G, Sijbrands, E J G, Franco, O H, Dehghan, A, Spector, T D, Dupuis, J, Hivert, M F, Rotter, J I, Meigs, J B, Pankow, J S, van Meurs, J B J, Isaacs, A, Boomsma, D I, Bell, J T, Demirkan, A & van Duijn, C M 2019, ' An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis ', Nature Communications, vol. 10, 2581, pp. 1-11 . https://doi.org/10.1038/s41467-019-10487-4
Nature Communications, 10:2581, 1-11. Nature Publishing Group
Nat. Commun. 10:2581 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications

Despite existing reports on differential DNA methylation in type 2 diabetes (T2D) and obesity, our understanding of its functional relevance remains limited. Here we show the effect of differential methylation in the early phases of T2D pathology by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c4c694350da37c4a64da57355aac00

Peripheral Blood Transcriptomic Signatures of Fasting Glucose and Insulin Concentrations

Autor: Joyce B. J. van Meurs, Eric D. Kolaczyk, Roby Joehanes, Caroline S. Fox, Albert Hofman, Andrew B. Singleton, Jose C. Florez, Andrew D. Johnson, Denis Rybin, Magic Investigators, Jaeyoung Hong, Lorna W. Harries, Lisa Pham, James B. Meigs, André G. Uitterlinden, Daniel Levy, Josée Dupuis, Stefania Bandinelli, Marie-France Hivert, Luigi Ferrucci, Dena G. Hernandez, Luke C. Pilling, Marjolein J. Peters, Brian H. Chen, Peter J. Munson, Abbas Dehghan, John D. Hogan, Saixia Ying, David Melzer

Publikováno v: Diabetes
Diabetes, 65(12), 3794-3804. American Diabetes Association Inc.

Genome-wide association studies (GWAS) have successfully identified genetic loci associated with glycemic traits. However, characterizing the functional significance of these loci has proven challenging. We sought to gain insights into the regulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9fb5fd5b775c231e08cf5697a47a62
https://doi.org/10.2337/db16-0470

Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand

Autor: Joyce J B van Meurs, Ingrid Meulenbelt, David T. Felson, Cindy G. Boer, Wouter den Hollander, Sarah Metrustry, Rob G H H Nelissen, Linda Broer, Marjolein J. Peters, Tim D. Spector, Margreet Kloppenburg, P. Eline Slagboom, L. Adrienne Cupples, Yolande F M Ramos, Deborah J. Hart, Joris Deelen, André G. Uitterlinden, Albert Hofman, Michelle S. Yau, Ana M. Valdes, Fernando Rivadeneira

Publikováno v: Hollander, W D, Boer, C G, Hart, D J, Yau, M S, Ramos, Y F M, Metrustry, S, Broer, L, Deelen, J, Cupples, L A, Rivadeneira, F, Kloppenburg, M, Peters, M, Spector, T D, Hofman, A, Slagboom, P E, Nelissen, R G H H, Uitterlinden, A G, Felson, D T, Valdes, A M, Meulenbelt, I & van Meurs, J J B 2017, ' Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand ', Annals of the rheumatic diseases, vol. 76, no. 12, pp. 2046-2053 . https://doi.org/10.1136/annrheumdis-2017-211214
Annals of the Rheumatic Diseases, 76(12), 2046-2053. BMJ Publishing Group
Ann Rheum Dis
Annals of the Rheumatic Diseases, 76(12), 2046-2053

ObjectiveOsteoarthritis (OA) is the most common form of arthritis and the leading cause of disability in the elderly. Of all the joints, genetic predisposition is strongest for OA of the hand; however, only few genetic risk loci for hand OA have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da9c8e8ebbc92551bb339536f8a8ff3
https://kclpure.kcl.ac.uk/en/publications/4f456cb1-12e6-4933-8e03-b43c5ecd3d24