Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Marjolein Garsen"'
Autor:
Baranca Buijsers, Marjolein Garsen, Mark de Graaf, Marinka Bakker-van Bebber, Chunming Guo, Xue Li, Johan van der Vlag
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: The endothelial glycocalyx degrading enzyme heparanase-1 (HPSE1) is a major contributor to kidney diseases, such as glomerulonephritis and diabetic nephropathy. Therefore, inhibition of HPSE1 could be an interesting therapeutic strategy
Externí odkaz:
https://doaj.org/article/a7517a03f86d40e8a0e1cafc4440f22e
Autor:
Marjolein Garsen, Baranca Buijsers, Marloes Sol, Lena Gockeln, Ramon Sonneveld, Toin H. van Kuppevelt, Mark de Graaf, Jacob van den Born, Jan A.A.M. Kamps, Daniël H. van Raalte, Rutger W. van der Meer, Hildo J. Lamb, Jan-Luuk Hillebrands, Ton J. Rabelink, Marissa L. Maciej-Hulme, Guido Krenning, Tom Nijenhuis, Johan van der Vlag
Publikováno v:
EBioMedicine, Vol 90, Iss , Pp 104506- (2023)
Summary: Background: Proteinuria is associated with many glomerular diseases and a risk factor for the progression to renal failure. We previously showed that heparanase (HPSE) is essential for the development of proteinuria, whereas peroxisome proli
Externí odkaz:
https://doaj.org/article/13deeeb23f314fa5bfa8672de7b2f11d
Autor:
Marjolein Garsen, Angelique L Rops, Jinhua Li, Katrien van Beneden, Christiane van den Branden, Jo Hm Berden, Ton J Rabelink, Johan van der Vlag
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160894 (2016)
Endothelial nitric oxide synthase (eNOS) deficiency exacerbates proteinuria and renal injury in several glomerular diseases, but the underlying mechanism is not fully understood. We recently showed that heparanase is essential for the development of
Externí odkaz:
https://doaj.org/article/481a9cdddd304ca2b2fd5399ff13b96c
Publikováno v:
Therapeutic Innovation & Regulatory Science
Background Cancer is a serious global health problem and a major cause of death. The European Medicines Agency (EMA) has established several regulatory initiatives to expedite the development and authorization of drugs to ensure timely access of pati
Publikováno v:
Therapeutic Innovation & Regulatory Science
Background Recent scientific advances in cancer research have led to the development of immunomodulatory and molecularly targeted drugs with better safety profiles than chemotherapeutics, which makes it possible to include healthy volunteers (HVs) in
Autor:
Markus A. Loeven, Markus H. Hoffmann, Julia M. Hofstra, Elmar Pieterse, Marjolein Garsen, Olivier W H van der Heijden, Hanneke K Knaapen, Johan van der Vlag, Nils Rother, Jo H. M. Berden, Luuk B. Hilbrands, Simon C. Satchell
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology, 37, 7, pp. 1371-1379
Arteriosclerosis, Thrombosis, and Vascular Biology, 37, 1371-1379
Arteriosclerosis, Thrombosis, and Vascular Biology, 37, 1371-1379
Objective— An excessive release and impaired degradation of neutrophil extracellular traps (NETs) leads to the continuous exposure of NETs to the endothelium in a variety of hematologic and autoimmune disorders, including lupus nephritis. This stud
Autor:
Angelique L.W.M.M. Rops, Joost G. J. Hoenderop, Tom Nijenhuis, Marjolein Garsen, Jo H. M. Berden, Ramon Sonneveld, Toin H. van Kuppevelt, Johan van der Vlag, Ton J. Rabelink, Suzanne Huntink
Publikováno v:
The Journal of Pathology. 237:472-481
The glomerular filtration barrier consists of podocytes, the glomerular basement membrane, and endothelial cells covered with a glycocalyx. Heparan sulphate (HS) in the glomerular filtration barrier is reduced in patients with proteinuria, which is a
Autor:
Marjolein Garsen, Ganqi Wang, Michael Elkin, Johan van der Vlag, Ton J. Rabelink, Bernard M. van den Berg
Publikováno v:
Nature Reviews. Nephrology, 13, 4, pp. 201-212
Nature Reviews Nephrology, 13(4), 201-212
Nature Reviews. Nephrology, 13, 201-212
Nature Reviews Nephrology, 13(4), 201-212
Nature Reviews. Nephrology, 13, 201-212
Item does not contain fulltext Heparanase has regulatory roles in various processes, including cell communication, gene transcription and autophagy. In addition, it is the only known mammalian endoglycosidase that is capable of degrading heparan sulf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801c2374ed65a10a4a45240a34d9ca81
https://hdl.handle.net/1887/95108
https://hdl.handle.net/1887/95108
Autor:
Johan van der Vlag, Olivia Lenoir, Marjolein Garsen, Henry B.P.M. Dijkman, Ton J. Rabelink, Angelique L.W.M.M. Rops, Brigith Willemsen, Jo H. M. Berden, Pierre-Louis Tharaux, Toin H. van Kuppevelt
Publikováno v:
Journal of the American Society of Nephrology, 27, 3545-3551
Journal of the American Society of Nephrology, 27(12), 3545-3551
Journal of the American Society of Nephrology, 27, 12, pp. 3545-3551
Journal of the American Society of Nephrology, 27(12), 3545-3551
Journal of the American Society of Nephrology, 27, 12, pp. 3545-3551
Contains fulltext : 172463.pdf (Publisher’s version ) (Closed access) Diabetic nephropathy (DN) is the leading cause of CKD in the Western world. Endothelin receptor antagonists have emerged as a novel treatment for DN, but the mechanisms underlyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679e1b3947f4dc126d71ef9ec6b9b2e7
https://doi.org/10.1681/asn.2015091070
https://doi.org/10.1681/asn.2015091070
Autor:
Thomas Reinheckel, Brigith Willemsen, Johan van der Vlag, Ton J. Rabelink, Angelique L.W.M.M. Rops, Toin H. van Kuppevelt, Marjolein Garsen, Jo H. M. Berden, Frans G. M. Russel, Henry B.P.M. Dijkman
Publikováno v:
Kidney International. Supplement, 90, 1012-1022
Kidney International. Supplement, 90, 5, pp. 1012-1022
Kidney International, 90(5), 1012-1022
Kidney International. Supplement, 90, 5, pp. 1012-1022
Kidney International, 90(5), 1012-1022
Contains fulltext : 170839.pdf (Publisher’s version ) (Closed access) Proteinuria is one of the first clinical signs of diabetic nephropathy and an independent predictor for the progression to renal failure. Cathepsin L, a lysosomal cysteine protea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6587c616302a762ab593a32fd1993218
https://doi.org/10.1016/j.kint.2016.06.035
https://doi.org/10.1016/j.kint.2016.06.035