Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Marjolein Crabbe"'
Autor:
Kim Thys, Matthew J. Loza, Linghua Lynn, Katleen Callewaert, Lisa Varma, Marjolein Crabbe, Liesbeth Van Wesenbeeck, Erika Van Landuyt, Sandra De Meyer, Jeroen Aerssens, Inge Verbrugge
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract We examined candidate biomarkers for efficacy outcomes in hospitalized COVID-19 patients who were treated with sirukumab, an IL-6 neutralizing antibody, in a randomized, double-blind, placebo-controlled, phase 2 trial. Between May 2020 and M
Externí odkaz:
https://doaj.org/article/d81d7c2b56ac49389a4e6701a820f8ef
Autor:
Deniz Öner, Charlotte Vernhes, Sunita Balla-Jhagjhoorsingh, Annick Moureau, Marjolein Crabbe, Bruno Salaun, Arangassery Rosemary Bastian, Kim Thys, Jonathan De Smedt, Salo N. Ooft, Koos Korsten, Niels Adriaenssens, Samuel Coenen, Christopher C. Butler, Theo J. M. Verheij, Simon B. Drysdale, Joanne G. Wildenbeest, Andrew J. Pollard, Peter J. M. Openshaw, Louis Bont, Jeroen Aerssens
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionRespiratory syncytial virus (RSV) causes acute respiratory tract infection (ARTI) and reinfects adults throughout life, posing a risk for hospitalization in older adults (>60 years) with frailty and comorbidities.MethodsTo investigate ser
Externí odkaz:
https://doaj.org/article/839c9c31db9446dfb139f163fcdff773
Autor:
Nevena Zivanovic, Deniz Öner, Yann Abraham, Joseph McGinley, Simon B. Drysdale, Joanne G. Wildenbeest, Marjolein Crabbe, Greet Vanhoof, Kim Thys, Ryan S. Thwaites, Hannah Robinson, Louis Bont, Peter J. M. Openshaw, Federico Martinón‐Torres, RESCEU Investigators, Andrew J. Pollard, Jeroen Aerssens
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 12, Pp n/a-n/a (2023)
Abstract Whereas most infants infected with respiratory syncytial virus (RSV) show no or only mild symptoms, an estimated 3 million children under five are hospitalized annually due to RSV disease. This study aimed to investigate biological mechanism
Externí odkaz:
https://doaj.org/article/ac35e4f76db64145b22518aa1ef50b98
Autor:
Nádia Conceição-Neto, Wim Pierson, Maurizio Vacca, Matthias Beyens, Ben De Clerck, Liese Aerts, Birgit Voeten, Dorien De Pooter, Lore Verschueren, Koen Dockx, Mathias Vandenberk, Ewoud De Troyer, Kato Verwilt, Carl Van Hove, Mieke Verslegers, Leslie Bosseler, Marjolein Crabbe, Vinod Krishna, Isabel Nájera, Ellen Van Gulck
Publikováno v:
Vaccines, Vol 11, Iss 12, p 1825 (2023)
Background: Suppression of HBV DNA, inhibition of HBV surface (HBsAg) production and therapeutic vaccination to reverse HBV-specific T-cell exhaustion in chronic HBV patients are likely required to achieve a functional cure. In the AAV-HBV mouse mode
Externí odkaz:
https://doaj.org/article/02d6e9e3b591445ea06f0b781cc5a5c2
Autor:
Bie Verbist, Eva Adriaensen, Vikki Keersmaekers, Dea Putri, Marjolein Crabbe, Maarten Derks, Rytis Bagdziunas, Griet Laenen, Hans De Wolf
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-10 (2019)
Abstract Background The QuantiGene® Plex 2.0 platform (ThermoFisher Scientific) combines bDNA with the Luminex/xMAP magnetic bead capturing technology to assess differential gene expression in a compound exposure setting. This technology allows mult
Externí odkaz:
https://doaj.org/article/3125803010e94c3086a197f2d1965640
Autor:
Dirk Roymans, Sarhad S Alnajjar, Michael B Battles, Panchan Sitthicharoenchai, Polina Furmanova-Hollenstein, Peter Rigaux, Joke Van den Berg, Leen Kwanten, Marcia Van Ginderen, Nick Verheyen, Luc Vranckx, Steffen Jaensch, Eric Arnoult, Richard Voorzaat, Jack M. Gallup, Alejandro Larios-Mora, Marjolein Crabbe, Dymphy Huntjens, Pierre Raboisson, Johannes P. Langedijk, Mark R. Ackermann, Jason S McLellan, Sandrine Vendeville, Anil Koul
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Respiratory syncytial virus causes lung infections in children, immunocompromised adults, and in the elderly. Here the authors show that a chemical inhibitor to a viral fusion protein is effective in reducing viral titre and ameliorating infection in
Externí odkaz:
https://doaj.org/article/a53af0caadf64c108081ce0c70f541ee
Autor:
Olivia Goethals, Suzanne J. F. Kaptein, Bart Kesteleyn, Jean-François Bonfanti, Liesbeth Van Wesenbeeck, Dorothée Bardiot, Ernst J. Verschoor, Babs E. Verstrepen, Zahra Fagrouch, J. Robert Putnak, Dominik Kiemel, Oliver Ackaert, Roel Straetemans, Sophie Lachau-Durand, Peggy Geluykens, Marjolein Crabbe, Kim Thys, Bart Stoops, Oliver Lenz, Lotke Tambuyzer, Sandra De Meyer, Kai Dallmeier, Michael K. McCracken, Gregory D. Gromowski, Wiriya Rutvisuttinunt, Richard G. Jarman, Nicos Karasavvas, Franck Touret, Gilles Querat, Xavier de Lamballerie, Laurent Chatel-Chaix, Gregg N. Milligan, David W. C. Beasley, Nigel Bourne, Alan D. T. Barrett, Arnaud Marchand, Tim H. M. Jonckers, Pierre Raboisson, Kenny Simmen, Patrick Chaltin, Ralf Bartenschlager, Willy M. Bogers, Johan Neyts, Marnix Van Loock
Publikováno v:
Nature. 615:678-686
Dengue is a major health threat and the number of symptomatic infections caused by the four dengue serotypes is estimated to be 96 million1 with annually around 10,000 deaths2. However, no antiviral drugs are available for the treatment or prophylaxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f8c0a4183f19bf33ac0d110d21b457f
https://doi.org/10.1038/s41586-023-05790-6
https://doi.org/10.1038/s41586-023-05790-6
Autor:
Wim Pierson, Marianne Tuefferd, Florence Herschke, Leen Slaets, Marjolein Crabbe, Dorien Verstappen, Steffi De Pelsmaeker, Ian Strickland, Edward J Gane, Christian Schwabe, Yingjie Zhang, Peter Meerts, Joris Vandenbossche, Pieter Van Remoortere, Inge Verbrugge, An De Creus
Publikováno v:
Antiviral Therapy. 28:135965352311728
Background Chronic hepatitis B (CHB) is responsible for major disease burden worldwide. However, the number of available therapies is limited; cure remains an elusive goal. JNJ-64794964 (JNJ-4964) is an oral toll-like receptor-7 (TLR7) agonist being
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::907c3e6cb9893ef4af40ac097e45b8da
https://doi.org/10.1177/13596535231172878
https://doi.org/10.1177/13596535231172878
Autor:
Bart Rudolf Romanie Kesteleyn, Suzanne J.F. Kaptein, Xavier de Lamballerie, Kenny Simmen, Arnaud Marchand, Jean-François Bonfanti, Max Münster, Laurent Chatel-Chaix, Marjolein Crabbe, Johan Neyts, Marnix Van Loock, Kai Dallmeier, Gilles Querat, Franck Touret, Kim Thys, Olivia Goethals, Dorothée Bardiot, Tim H. M. Jonckers, Pierre Jean-Marie Bernard Raboisson, Peggy Geluykens, Dominik Kiemel, Patrick Chaltin, Bart Stoops, Ralf Bartenschlager
Dengue virus causes approximately 96 million symptomatic infections annually, manifesting as dengue fever or occasionally as severe dengue1,2. There are no antiviral agents available to prevent or treat dengue. Here, we describe a highly potent dengu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0f695891d12a95fecae329bcce0424
https://lirias.kuleuven.be/handle/123456789/683277
https://lirias.kuleuven.be/handle/123456789/683277
Autor:
Suzanne J F, Kaptein, Olivia, Goethals, Dominik, Kiemel, Arnaud, Marchand, Bart, Kesteleyn, Jean-François, Bonfanti, Dorothée, Bardiot, Bart, Stoops, Tim H M, Jonckers, Kai, Dallmeier, Peggy, Geluykens, Kim, Thys, Marjolein, Crabbe, Laurent, Chatel-Chaix, Max, Münster, Gilles, Querat, Franck, Touret, Xavier, de Lamballerie, Pierre, Raboisson, Kenny, Simmen, Patrick, Chaltin, Ralf, Bartenschlager, Marnix, Van Loock, Johan, Neyts
Publikováno v:
Nature. 598(7881)
Dengue virus causes approximately 96 million symptomatic infections annually, manifesting as dengue fever or occasionally as severe dengue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e4e1de640eac35dd21665b2d7bca5ffa
https://pubmed.ncbi.nlm.nih.gov/34697477
https://pubmed.ncbi.nlm.nih.gov/34697477