Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Marjolein C. Olthof"'
Autor:
Linda Smit, Gert J. Ossenkoppele, Gerrit Jan Schuurhuis, Walter Pouwels, Arjo P. Rutten, Marjolein C. Olthof, Fedor Denkers, David C. de Leeuw
XLSX file - 54KB, Genes correlated with microRNA-126 expression in 163 AML patients show overlap with stem cell genes: Genes positively and negatively associated with miR-126 expression in 163 AML patients as published by (34). 854 genes were signifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be0071c09a534453e4a690227defec8
https://doi.org/10.1158/0008-5472.22400873
https://doi.org/10.1158/0008-5472.22400873
Autor:
Linda Smit, Gert J. Ossenkoppele, Gerrit Jan Schuurhuis, Walter Pouwels, Arjo P. Rutten, Marjolein C. Olthof, Fedor Denkers, David C. de Leeuw
XLSX file - 15KB, MicroRNAs differentially expressed between LSC and HSC (at least 2 out of 3 patients): Upper: MicroRNA expression ratios between CD34+CD38-ALDHlow/dim(LSC) and CD34+CD38-ALDHhigh (HSC) populations obtained from microarray analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205a160304b367da8233636005be81c1
https://doi.org/10.1158/0008-5472.22400879.v1
https://doi.org/10.1158/0008-5472.22400879.v1
Autor:
Linda Smit, Gert J. Ossenkoppele, Gerrit Jan Schuurhuis, Walter Pouwels, Arjo P. Rutten, Marjolein C. Olthof, Fedor Denkers, David C. de Leeuw
PDF file - 93KB, Validation of microarray by qRT-PCR: Surplus RNA from LSC and progenitor populations that remained after array hybridization was used for the validation of the microarray results. MicroRNA expression analysis was performed by qRT-PCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b8e2baf628802165bd4cdb64bef018
https://doi.org/10.1158/0008-5472.22400888.v1
https://doi.org/10.1158/0008-5472.22400888.v1
Autor:
Linda Smit, Gert J. Ossenkoppele, Gerrit Jan Schuurhuis, Walter Pouwels, Arjo P. Rutten, Marjolein C. Olthof, Fedor Denkers, David C. de Leeuw
Despite high remission rates after therapy, 60% to 70% of patients with acute myeloid leukemia (AML) do not survive 5 years after their initial diagnosis. The main cause of treatment failures may be insufficient eradication of a subpopulation of leuk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b90833b30d62cbe27366d54f5243b459
https://doi.org/10.1158/0008-5472.c.6505712
https://doi.org/10.1158/0008-5472.c.6505712
Autor:
Linda Smit, Gert J. Ossenkoppele, Gerrit Jan Schuurhuis, Walter Pouwels, Arjo P. Rutten, Marjolein C. Olthof, Fedor Denkers, David C. de Leeuw
XLSX file - 14KB, MicroRNAs differentially expressed between LSC and progenitors (at least 4 out of 6 patients): Upper: MicroRNA expression ratios between CD34+CD38-ALDHlow/dim (LSC) and CD34+CD38+ALDHlow/dim (malignant progenitor) populations obtain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019666fb44cfba1d1cbae8ef5b62b192
https://doi.org/10.1158/0008-5472.22400882
https://doi.org/10.1158/0008-5472.22400882
Autor:
Linda Smit, Gert J. Ossenkoppele, Gerrit Jan Schuurhuis, Walter Pouwels, Arjo P. Rutten, Marjolein C. Olthof, Fedor Denkers, David C. de Leeuw
XLSX file - 11KB, MicroRNA-126 is highly expressed in core binding factor AML: qRT-PCR results of miR-126 in CD34+CD38-ALDHlow/dim LSC and CD34+CD38+ALDHlow/dim leukemic progenitors in 18 AML patients. Cytogenetics indicates the presence of a CBF kar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0289ab5a2574ac15e921379c7d167de7
https://doi.org/10.1158/0008-5472.22400876
https://doi.org/10.1158/0008-5472.22400876
Autor:
Linda Smit, Gert J. Ossenkoppele, Gerrit Jan Schuurhuis, Walter Pouwels, Arjo P. Rutten, Marjolein C. Olthof, Fedor Denkers, David C. de Leeuw
XLSX file - 9KB, Patient characteristics and stem cell frequencies: Patient characteristics and stem cell frequencies of samples used for miRNA expression profiling using microarray. Molecular aberrancy indicates the aberrancy as detected by routine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2737060d34c085bd0b4b222574dbc027
https://doi.org/10.1158/0008-5472.22400885.v1
https://doi.org/10.1158/0008-5472.22400885.v1
Autor:
Roel Broekhuizen, Stefanie A. H. de Poot, Jan Meeldijk, Elisabeth M. P. Steeghs, Elisabeth A. van Erp, Roel Goldschmeding, Niels Bovenschen, Marjolein C. Olthof
Publikováno v:
Blood. 126:2893-2895
To the editor: With great interest, we read the recent Blood article by Vrazo et al,[1][1] who report on the use of luciferase-based biosensors to detect proteolytic activity of granzymes (Gr’s) A, B, and K. They show that these sensors can be used
Autor:
Gert J. Ossenkoppele, Arjo P Rutten, Linda Smit, David C. de Leeuw, Marjolein C. Olthof, Gerrit Jan Schuurhuis, Walter Pouwels, Fedor Denkers
Publikováno v:
de Leeuw, D C, Denkers, F, Olthof, M C, Rutten, A P, Pouwels, W, Schuurhuis, G J, Ossenkoppele, G J & Smit, L 2014, ' Attenuation of microRNA-126 Expression That Drives CD34(+)38 Stem/Progenitor Cells in Acute Myeloid Leukemia Leads to Tumor Eradication ', Cancer Research, vol. 74, no. 7, pp. 2094-2105 . https://doi.org/10.1158/0008-5472.CAN-13-1733
Cancer Research, 74(7), 2094-2105. American Association for Cancer Research Inc.
Cancer Research, 74(7), 2094-2105. American Association for Cancer Research Inc.
Despite high remission rates after therapy, 60% to 70% of patients with acute myeloid leukemia (AML) do not survive 5 years after their initial diagnosis. The main cause of treatment failures may be insufficient eradication of a subpopulation of leuk