Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Marjoke F, Debets"'
Autor:
Severine Isabelle Gharbi, Laura A. Pelletier, Alfonso Espada, Jesus Gutiérrez, Sonia Maria Gutiérrez Sanfeliciano, Charles T. Rauch, Maria Patricia Ganado, Carmen Baquero, Elisabet Zapatero, Aiping Zhang, Jordi Benach, Anna-Maria Russell, Leticia Cano, Sandra Gomez, Howard Broughton, Nicholas Pulliam, Carmen Maria Perez, Raquel Torres, Marjoke F. Debets, Alfonso de Dios, Oscar Puig, Mark T. Hilgers, Maria Jose Lallena
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Despite the biological and therapeutic relevance of CDK4/6 for the treatment of HR+, HER2- advanced breast cancer, the detailed mode of action of CDK4/6 inhibitors is not completely understood. Of particular interest, phosphorylation of CDK4
Externí odkaz:
https://doaj.org/article/a4901c8cc1f2445081034949720c4383
Autor:
Severine Isabelle Gharbi, Laura A. Pelletier, Alfonso Espada, Jesus Gutiérrez, Sonia Maria Gutiérrez Sanfeliciano, Charles T. Rauch, Maria Patricia Ganado, Carmen Baquero, Elisabet Zapatero, Aiping Zhang, Jordi Benach, Anna-Maria Russell, Leticia Cano, Sandra Gomez, Howard Broughton, Nicholas Pulliam, Carmen Maria Perez, Raquel Torres, Marjoke F. Debets, Alfonso de Dios, Oscar Puig, Mark T. Hilgers, Maria Jose Lallena
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/3b011c3c5bd0459a9b47a137f7b7d6fd
Autor:
Pooja Gangras, Valentina Gelfanova, Graham D. Williams, Samuel K. Handelman, Ryan M. Smith, Marjoke F. Debets
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 23; Pages: 15062
The SH-SY5Y neuroblastoma cells are a widely used in vitro model approximating neurons for testing the target engagement of therapeutics designed for neurodegenerative diseases and pain disorders. However, their potential as a model for receptor-medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05bbf2a8543dd3bd43628206a3cec03e
Autor:
Kirsten Deprey, Nefeli Batistatou, Marjoke F. Debets, Jack Godfrey, Kirstin B. VanderWall, Rebecca R. Miles, Livia Shehaj, Jiaxing Guo, Amy Andreucci, Pachamuthu Kandasamy, Genliang Lu, Mamoru Shimizu, Chandra Vargeese, Joshua A. Kritzer
Publikováno v:
ACS Chem Biol
A major obstacle to the development of effective oligonucleotide therapeutics is a lack of understanding about their cytosolic and nuclear penetration. To address this problem, we have applied the chloroalkane penetration assay (CAPA) to oligonucleot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca7a1a52699e0b7e5fa1b2efc41faf6
https://europepmc.org/articles/PMC9252293/
https://europepmc.org/articles/PMC9252293/
Autor:
Anna Cioce, Chloe Roustan, Jacob T. Bush, Svend Kjaer, Ganka Bineva-Todd, Holly L. Douglas, Benjamin Schumann, William M. Browne, Junwon Choi, Marjoke F. Debets, Anthony J. Agbay, Omur Y. Tastan, Carolyn R. Bertozzi, Thomas M. Wood
Publikováno v:
ACS Chemical Biology
Metabolic oligosaccharide engineering (MOE) has fundamentally contributed to our understanding of protein glycosylation. Efficient MOE reagents are activated into nucleotide-sugars by cellular biosynthetic machineries, introduced into glycoproteins a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::940507725028278d1318b4b423192642
Autor:
Marjoke F, Debets, Omur Y, Tastan, Simon P, Wisnovsky, Stacy A, Malaker, Nikolaos, Angelis, Leonhard K R, Moeckl, Junwon, Choi, Helen, Flynn, Lauren J S, Wagner, Ganka, Bineva-Todd, Aristotelis, Antonopoulos, Anna, Cioce, William M, Browne, Zhen, Li, David C, Briggs, Holly L, Douglas, Gaelen T, Hess, Anthony J, Agbay, Chloe, Roustan, Svend, Kjaer, Stuart M, Haslam, Ambrosius P, Snijders, Michael C, Bassik, W E, Moerner, Vivian S W, Li, Carolyn R, Bertozzi, Benjamin, Schumann
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Most human secreted and cell surface proteins are modified by Ser/Thr(O)-linked glycosylation with N-acetylgalactosamine (O-GalNAc). While of fundamental importance in health and disease, O-GalNAcglycosylation is technically challenging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9a0a79b1e532c559b79dbba6e19e0a6a
https://pubmed.ncbi.nlm.nih.gov/32989128
https://pubmed.ncbi.nlm.nih.gov/32989128
Autor:
Zachary Armstrong, Gideon J. Davies, Chi-Lin Kuo, Erwin R. van Rijssel, Thomas J. M. Beenakker, Bogdan I. Florea, Mario van der Stelt, Gijsbert M. van der Marel, Rachel Johnson, D. Lahav, Bing Liu, Colin Hissink, Marjoke F. Debets, Jeroen D. C. Codée, C.S. Wong, Johannes M. F. G. Aerts, Paul P. Geurink, Casper de Boer, Huib Ovaa, Rolf G. Boot, Liang Wu, Herman S. Overkleeft
Publikováno v:
Journal of the American Chemical Society, 142(30), 13021-13029
Journal of the American Chemical Society, 142(30), 13021-13029. AMER CHEMICAL SOC
Journal of the American Chemical Society, 142(30), 13021-13029. AMER CHEMICAL SOC
Golgi mannosidase II (GMII) catalyzes the sequential hydrolysis of two mannosyl residues from GIcNAc-Man(5)GlcNAc(2) to produce GlcNAcMan(3) GlcNAc(2), the precursor for all complex N-glycans, including the branched N-glycans associated with cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da58583ed50534d3a4c954ed79107c5
https://hdl.handle.net/1887/3134478
https://hdl.handle.net/1887/3134478
Autor:
Zachary, Armstrong, Chi-Lin, Kuo, Daniël, Lahav, Bing, Liu, Rachel, Johnson, Thomas J M, Beenakker, Casper, de Boer, Chung-Sing, Wong, Erwin R, van Rijssel, Marjoke F, Debets, Bogdan I, Florea, Colin, Hissink, Rolf G, Boot, Paul P, Geurink, Huib, Ovaa, Mario, van der Stelt, Gijsbert M, van der Marel, Jeroen D C, Codée, Johannes M F G, Aerts, Liang, Wu, Herman S, Overkleeft, Gideon J, Davies
Publikováno v:
Journal of the American Chemical Society. 142(30)
Golgi mannosidase II (GMII) catalyzes the sequential hydrolysis of two mannosyl residues from GlcNAcMan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cac10711038877c89d958cded3d208f4
https://pubmed.ncbi.nlm.nih.gov/32605368
https://pubmed.ncbi.nlm.nih.gov/32605368
Autor:
Vivian S. W. Li, Aristotelis Antononopoulos, Ambrosius P. Snijders, Nikolaos Angelis, Gaelen T. Hess, Lauren J. S. Wagner, Chloe Roustan, Marjoke F. Debets, Simon Wisnovsky, Stuart M. Haslam, David Briggs, Junwon Choi, Holly L. Douglas, Ganka Bineva-Todd, Stacy A. Malaker, Svend Kjaer, Anna Cioce, Helen R. Flynn, Michael C. Bassik, Omur Y. Tastan, Carolyn R. Bertozzi, W. E. Moerner, Zhen Li, Leonhard K. R. Moeckl, Anthony J. Agbay, Benjamin Schumann, William M. Browne
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Protein glycosylation events that happen early in the secretory pathway are often dysregulated during tumorigenesis. These events can be probed, in principle, by monosaccharides with bioorthogonal tags that would ideally be specific for distinct glyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333a97b1da54de34ec4a35a821247cd0
Autor:
Junwon Choi, Jennifer J. Kohler, Lauren J. S. Wagner, Benjamin Schumann, Anthony J. Agbay, Marjoke F. Debets, Daniel Fernández, Liang Lin, Simon Wisnovsky, Carolyn R. Bertozzi, Douglas Michael Fox, Melissa A. Gray, Stacy A. Malaker, Kayvon Pedram, Jessie Peh, Milan Mrksich
Studying posttranslational modifications classically relies on experimental strategies that oversimplify the complex biosynthetic machineries of living cells. Protein glycosylation contributes to essential biological processes, but correlating glycan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26fd121a491dec365b2f17a8c5e46179
https://doi.org/10.1101/669861
https://doi.org/10.1101/669861