Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Marjo K Hytönen"'
Autor:
Frode Lingaas, Katarina Tengvall, Johan Høgset Jansen, Lena Pelander, Maria H Hurst, Theo Meuwissen, Åsa Karlsson, Jennifer R S Meadows, Elisabeth Sundström, Stein Istre Thoresen, Ellen Frøysadal Arnet, Ole Albert Guttersrud, Marcin Kierczak, Marjo K Hytönen, Hannes Lohi, Åke Hedhammar, Kerstin Lindblad-Toh, Chao Wang
Publikováno v:
PLoS Genetics, Vol 19, Iss 1, p e1010599 (2023)
Chronic kidney disease (CKD) affects 10% of the human population, with only a small fraction genetically defined. CKD is also common in dogs and has been diagnosed in nearly all breeds, but its genetic basis remains unclear. Here, we performed a Baye
Externí odkaz:
https://doaj.org/article/c3c378efd65a49dc8c7bb3289499d511
Autor:
Kati J Dillard, Matthias Ochs, Julia E Niskanen, Meharji Arumilli, Jonas Donner, Kaisa Kyöstilä, Marjo K Hytönen, Marjukka Anttila, Hannes Lohi
Publikováno v:
PLoS Genetics, Vol 16, Iss 3, p e1008651 (2020)
Neonatal interstitial lung diseases due to abnormal surfactant biogenesis are rare in humans and have never been reported as a spontaneous disorder in animals. We describe here a novel lung disorder in Airedale Terrier (AT) dogs with clinical symptom
Externí odkaz:
https://doaj.org/article/d294350a987a459ba797340d52604151
Autor:
Maria Kaukonen, Ileana B Quintero, Abdul Kadir Mukarram, Marjo K Hytönen, Saila Holopainen, Kaisa Wickström, Kaisa Kyöstilä, Meharji Arumilli, Sari Jalomäki, Carsten O Daub, Juha Kere, Hannes Lohi, DoGA Consortium
Publikováno v:
PLoS Genetics, Vol 16, Iss 3, p e1008659 (2020)
Retinitis pigmentosa (RP) is the leading cause of blindness with nearly two million people affected worldwide. Many genes have been implicated in RP, yet in 30-80% of the RP patients the genetic cause remains unknown. A similar phenotype, progressive
Externí odkaz:
https://doaj.org/article/39d51ff8395f4e6585da637aea5f289e
Autor:
Lea I Mikkola, Saila Holopainen, Anu K Lappalainen, Tiina Pessa-Morikawa, Thomas J P Augustine, Meharji Arumilli, Marjo K Hytönen, Osmo Hakosalo, Hannes Lohi, Antti Iivanainen
Publikováno v:
PLoS Genetics, Vol 15, Iss 7, p e1008197 (2019)
Canine hip dysplasia is a common, non-congenital, complex and hereditary disorder. It can inflict severe pain via secondary osteoarthritis and lead to euthanasia. An analogous disorder exists in humans. The genetic background of hip dysplasia in both
Externí odkaz:
https://doaj.org/article/3bbb4250dd4f494289b52428242f31ab
Autor:
Anina Bauer, Vidhya Jagannathan, Sandra Högler, Barbara Richter, Neil A McEwan, Anne Thomas, Edouard Cadieu, Catherine André, Marjo K Hytönen, Hannes Lohi, Monika M Welle, Petra Roosje, Cathryn Mellersh, Margret L Casal, Tosso Leeb
Publikováno v:
PLoS Genetics, Vol 14, Iss 3, p e1007264 (2018)
Lethal acrodermatitis (LAD) is a genodermatosis with monogenic autosomal recessive inheritance in Bull Terriers and Miniature Bull Terriers. The LAD phenotype is characterized by poor growth, immune deficiency, and skin lesions, especially at the paw
Externí odkaz:
https://doaj.org/article/00d133befa1a4234a8f5487df49c7e40
Autor:
Kati J Dillard, Marjo K Hytönen, Daniel Fischer, Kimmo Tanhuanpää, Mari S Lehti, Katri Vainio-Siukola, Anu Sironen, Marjukka Anttila
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0204073 (2018)
Ciliopathies presenting as inherited hepatorenal fibrocystic disorders are rare in humans and in dogs. We describe here a novel lethal ciliopathy in Norwich Terrier puppies that was diagnosed at necropsy and characterized as diffuse cystic renal dise
Externí odkaz:
https://doaj.org/article/9747eb31e32e46fa8ee6969f5ee63378
Autor:
Saila Holopainen, Marjo K Hytönen, Pernilla Syrjä, Meharji Arumilli, Anna-Kaisa Järvinen, Minna Rajamäki, Hannes Lohi
Publikováno v:
PLoS Genetics, Vol 13, Iss 2, p e1006625 (2017)
Acute respiratory distress syndrome (ARDS) is the leading cause of death in critical care medicine. The syndrome is typified by an exaggerated inflammatory response within the lungs. ARDS has been reported in many species, including dogs. We have pre
Externí odkaz:
https://doaj.org/article/d87faa9db1c94a0fab15fc2d5d12b233
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184659 (2017)
Toxoplasma gondii is a widespread zoonotic parasite that is relevant for veterinary and public health. The domestic cat, the definitive host species with the largest worldwide population, has become evolutionarily and epidemiologically the most impor
Externí odkaz:
https://doaj.org/article/2767c9b61cf44e2d9832d19e245fb659
Autor:
Julia Niskanen, Kati Dillard, Meharji Arumilli, Elina Salmela, Marjukka Anttila, Hannes Lohi, Marjo K Hytönen
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177527 (2017)
A rare hereditary mechanobullous disorder called epidermolysis bullosa (EB) causes blistering in the skin and the mucosal membranes. To date, nineteen EB-related genes have been discovered in human and other species. We describe here a novel EB varia
Externí odkaz:
https://doaj.org/article/1e6e4a18d36942588b8ea956b8a87041
Autor:
Marjo K Hytönen, Meharji Arumilli, Anu K Lappalainen, Marta Owczarek-Lipska, Vidhya Jagannathan, Sruthi Hundi, Elina Salmela, Patrick Venta, Eva Sarkiala, Tarja Jokinen, Daniela Gorgas, Juha Kere, Pekka Nieminen, Cord Drögemüller, Hannes Lohi
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1006037 (2016)
One to two percent of all children are born with a developmental disorder requiring pediatric hospital admissions. For many such syndromes, the molecular pathogenesis remains poorly characterized. Parallel developmental disorders in other species cou
Externí odkaz:
https://doaj.org/article/d91245e1d3c540c592445a06e5a45ccc