Výsledky vyhledávání - "Marjo J. den Broeder"

Akademický článek

Insulin-like 3 affects zebrafish spermatogenic cells directly and via Sertoli cells

Autor: Diego Crespo, Luiz H. C. Assis, Yu Ting Zhang, Diego Safian, Tomasz Furmanek, Kai Ove Skaftnesmo, Birgitta Norberg, Wei Ge, Yung-Ching Choi, Marjo J. den Broeder, Juliette Legler, Jan Bogerd, Rüdiger W. Schulz

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)

Insulin-like 3 (Insl3) belongs to a class of peptide hormones that are expressed in the Leydig cells and, in zebrafish, under the control of folliclestimulating hormone (Fsh) in the pituitary. Using insl3 knockout zebrafish, the authors found that In

Externí odkaz: https://doaj.org/article/4c9f06c43b914b4998cdd9cfb8ac7e39

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Akademický článek

Inhibition of methyltransferase activity of enhancer of zeste 2 leads to enhanced lipid accumulation and altered chromatin status in zebrafish

Autor: Marjo J. den Broeder, Jarle Ballangby, Leonie M. Kamminga, Peter Aleström, Juliette Legler, Leif C. Lindeman, Jorke H. Kamstra

Publikováno v: Epigenetics & Chromatin, Vol 13, Iss 1, Pp 1-16 (2020)

Abstract Background Recent studies indicate that exposure to environmental chemicals may increase susceptibility to developing metabolic diseases. This susceptibility may in part be caused by changes to the epigenetic landscape which consequently aff

Externí odkaz: https://doaj.org/article/0003cd4494f74699ad761b7c77e0dcea

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Akademický článek

Genetic and Epigenetic Regulation of Zebrafish Intestinal Development

Autor: Bilge San, Marco Aben, Dei M. Elurbe, Kai Voeltzke, Marjo J. den Broeder, Julien Rougeot, Juliette Legler, Leonie M. Kamminga

Publikováno v: Epigenomes, Vol 2, Iss 4, p 19 (2018)

Many regulatory pathways are conserved in the zebrafish intestine compared to mammals, rendering it a strong model to study intestinal development. However, the (epi)genetic regulation of zebrafish intestinal development remains largely uncharacteriz

Externí odkaz: https://doaj.org/article/0e2eb8ee77ab4b9b9f0b920c1bd8ff3b

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Interspecies Differences in Activation of Peroxisome Proliferator-Activated Receptor γ by Pharmaceutical and Environmental Chemicals

Autor: Clémentine, Garoche, Abdelhay, Boulahtouf, Marina, Grimaldi, Barbara, Chiavarina, Lucia, Toporova, Marjo J, den Broeder, Juliette, Legler, William, Bourguet, Patrick, Balaguer

Publikováno v: Environmental sciencetechnology. 55(24)

Endocrine disrupting chemicals (EDCs) are able to deregulate the hormone system, notably through interactions with nuclear receptors (NRs). The mechanisms of action and biological effects of many EDCs have mainly been tested on human and mouse but ot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e4b72ae6116579ba20738ca889828d70
https://pubmed.ncbi.nlm.nih.gov/34843233

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Akademický článek

Zebrafish as a Model to Study the Role of Peroxisome Proliferating-Activated Receptors in Adipogenesis and Obesity

Autor: Marjo J. Den Broeder, Victoria A. Kopylova, Leonie M. Kamminga, Juliette Legler

Publikováno v: PPAR Research, Vol 2015 (2015)

The Peroxisome Proliferator-Activated Receptors (PPARs) PPARA and PPARD are regulators of lipid metabolism with important roles in energy release through lipid breakdown, while PPARG plays a key role in lipid storage and adipogenesis. The aim of this

Externí odkaz: https://doaj.org/article/c4fe5b26710e48b19e32fb72c89ba65d

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Akademický článek

Generation and characterization of FMR1 knockout zebrafish.

Autor: Marjo J den Broeder, Herma van der Linde, Judith R Brouwer, Ben A Oostra, Rob Willemsen, René F Ketting

Publikováno v: PLoS ONE, Vol 4, Iss 11, p e7910 (2009)

Fragile X syndrome (FXS) is one of the most common known causes of inherited mental retardation. The gene mutated in FXS is named FMR1, and is well conserved from human to Drosophila. In order to generate a genetic tool to study FMR1 function during

Externí odkaz: https://doaj.org/article/6815080d89ce4b748a6126ecb66c5afb

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Akademický článek

The zebrafish mutants dre, uki, and lep encode negative regulators of the hedgehog signaling pathway.

Autor: Marco J Koudijs, Marjo J den Broeder, Astrid Keijser, Erno Wienholds, Saskia Houwing, Ellen M H C van Rooijen, Robert Geisler, Fredericus J M van Eeden

Publikováno v: PLoS Genetics, Vol 1, Iss 2, p e19 (2005)

Proliferation is one of the basic processes that control embryogenesis. To identify factors involved in the regulation of proliferation, we performed a zebrafish genetic screen in which we used proliferating cell nuclear antigen (PCNA) expression as

Externí odkaz: https://doaj.org/article/8bd3adef8eab45dd81adedcc6ae2fdbb

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Altered Adipogenesis in Zebrafish Larvae Following High Fat Diet and Chemical Exposure Is Visualised by Stimulated Raman Scattering Microscopy

Autor: Juliette Legler, Jorke H. Kamstra, Valentina Davidoiu, P.H. Cenijn, Miriam J. B. Moester, Marjo J. den Broeder, Johannes F. de Boer, Leonie M. Kamminga, Freek Ariese

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, 18(4). MDPI AG
den Broeder, M J, Moester, M J B, Kamstra, J H, Cenijn, P H, Davidoiu, V, Kamminga, L M, Ariese, F, de Boer, J F & Legler, J 2017, ' Altered Adipogenesis in Zebrafish Larvae Following High Fat Diet and Chemical Exposure Is Visualised by Stimulated Raman Scattering Microscopy ', International Journal of Molecular Sciences, vol. 18, no. 4, 894 . https://doi.org/10.3390/ijms18040894
International Journal of Molecular Sciences, 18, 4, pp. 1-21
International Journal of Molecular Sciences; Volume 18; Issue 4; Pages: 894
International Journal of Molecular Sciences, 18(4):894. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 18, Iss 4, p 894 (2017)
International Journal of Molecular Sciences, 18, 1-21

Early life stage exposure to environmental chemicals may play a role in obesity by altering adipogenesis; however, robust in vivo methods to quantify these effects are lacking. The goal of this study was to analyze the effects of developmental exposu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92b2a8e6e565a779f48f99d70294767

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Zebrafish as a Model to Study the Role of Peroxisome Proliferating-Activated Receptors in Adipogenesis and Obesity

Autor: Victoria A. Kopylova, Leonie M. Kamminga, Juliette Legler, Marjo J. den Broeder

Publikováno v: PPAR Research, Vol 2015 (2015)
Ppar Research, 2015, pp. 358029
PPAR Research
Ppar Research, 2015, 358029

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6415fa363101a67e8b9652b31b4ecac
https://doaj.org/article/c4fe5b26710e48b19e32fb72c89ba65d

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Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway

Autor: Fredericus J.M. van Eeden, Marjo J. den Broeder, Evelyn Groot, Marco J. Koudijs

Publikováno v: BMC Developmental Biology, 8. BioMed Central
BMC Developmental Biology, Vol 8, Iss 1, p 15 (2008)
BMC Developmental Biology

BackgroundAberrant activation of the Hedgehog (Hh) signaling pathway in different organisms has shown the importance of this family of morphogens during development. Genetic screens in zebrafish have assigned specific roles for Hh in proliferation, d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c58d2c5139b9133c9af9af16cd34b91
https://hdl.handle.net/20.500.11755/ac436fe3-e646-440b-8071-4096b9b3b46f

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