Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Marjo, Laitinen"'
Autor:
Teemu Natunen, Henna Martiskainen, Timo Sarajärvi, Seppo Helisalmi, Juha-Pekka Pursiheimo, Jayashree Viswanathan, Marjo Laitinen, Petra Mäkinen, Tarja Kauppinen, Tuomas Rauramaa, Ville Leinonen, Irina Alafuzoff, Annakaisa Haapasalo, Hilkka Soininen, Mikko Hiltunen
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80700 (2013)
Alzheimer's disease (AD) has been postulated to involve defects in the clearance of amyloid-β (Aβ). Activation of liver X receptor α (LXRα) increases the expression of apolipoprotein E (ApoE) as well as cholesterol transporters ABCA1 and ABCG1, l
Externí odkaz:
https://doaj.org/article/bd432ea45efc4cffa22cd97a2a5a43d8
Autor:
Lyzel S Elias-Sonnenschein, Seppo Helisalmi, Teemu Natunen, Anette Hall, Teemu Paajanen, Sanna-Kaisa Herukka, Marjo Laitinen, Anne M Remes, Anne M Koivisto, Kari M Mattila, Terho Lehtimäki, Frans R J Verhey, Pieter Jelle Visser, Hilkka Soininen, Mikko Hiltunen
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e59676 (2013)
OBJECTIVES: To understand the relation between risk genes for Alzheimer's disease (AD) and their influence on biomarkers for AD, we examined the association of AD in the Finnish cohort with single nucleotide polymorphisms (SNPs) from top AlzGene loci
Externí odkaz:
https://doaj.org/article/c9f56374400345e98bb710f9782bb034
Autor:
Terttu Särkioja, Helinä Hakko, Eino Solje, Mikko Hiltunen, Anne M. Remes, Pirkko Riipinen, Marjo Laitinen, Seppo Helisalmi
Publikováno v:
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17:589-592
Impulsive and aggressive traits are not only common features displayed by patients with behavioural variant frontotemporal dementia (bvFTD), they may well be the first clinical manifestations of the disease. In addition, suicidal behaviour has been p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::290ade34c3960e77d91f98cbfc8ce405
https://doi.org/10.1080/21678421.2016.1203337
https://doi.org/10.1080/21678421.2016.1203337
Autor:
Heli Koivumaa-Honkanen, Anne M. Remes, Marjo Laitinen, Mikko Hiltunen, Riikka Marttila, Seppo Helisalmi, Erika Jääskeläinen, Matti Isohanni, Eino Solje, Jouko Miettunen
Publikováno v:
Psychiatric Genetics. 26:92-94
Patients with behavioral variant frontotemporal dementia (bvFTD) have many psychotic symptoms, especially at the onset of the disease. The C9ORF72 expansion is the most common genetic etiology observed with bvFTD and the prevalence of the expansion i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6564235df251b78898cef7e700ab18
https://doi.org/10.1097/ypg.0000000000000118
https://doi.org/10.1097/ypg.0000000000000118
Autor:
Anne M. Koivisto, Tuomas Rauramaa, Juha E. Jääskeläinen, Jussi Paananen, Hilkka Soininen, Ville Leinonen, Ritva Vanninen, Mitja I. Kurki, Marjo Laitinen, Maria Kojoukhova, Annakaisa Haapasalo, Anna Sutela, Joel Huovinen, Tiina Laiterä, Anne M. Remes, Seppo Helisalmi, Mikko Hiltunen
Publikováno v:
Journal of Alzheimer's disease : JAD. 60(3)
BACKGROUND Idiopathic normal pressure hydrocephalus (iNPH) is a late onset, surgically treated progressive brain disease caused by impaired cerebrospinal fluid dynamics and subsequent ventriculomegaly. Comorbid Alzheimer's disease (AD) seems to be fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf90bad297b2fd9bc29ce8b51efcde1
https://pubmed.ncbi.nlm.nih.gov/28984604
https://pubmed.ncbi.nlm.nih.gov/28984604
Autor:
Seppo Helisalmi, Laura Kytövuori, Mikko Hiltunen, Maria Marttila, Mikko Kärppä, Mika Kallio, Kari Majamaa, Marjo Laitinen
Publikováno v:
Neuroepidemiology. 49(1-2)
Background: Charcot-Marie-Tooth (CMT) disease is the most common hereditary neuromuscular disorder with a population prevalence of 9.7-82.3/100,000. In this study, we have estimated the prevalence of CMT and its subtypes in Finland and examined the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68e7974c03267a33e3cdc1aa2e5e862
https://pubmed.ncbi.nlm.nih.gov/28810241
https://pubmed.ncbi.nlm.nih.gov/28810241
Autor:
Mitja I. Kurki, Anne M. Remes, Anette Hall, Henna Martiskainen, Ville Leinonen, Terho Lehtimäki, Mikko Hiltunen, Anne M. Koivisto, Kari M. Mattila, Hilkka Soininen, Timo Sarajärvi, Marjo Laitinen, Seppo Helisalmi, Petra Mäkinen, Teemu Natunen, Jayashree Viswanathan, Kaisa M.A. Kurkinen, Sanna-Kaisa Herukka, Annakaisa Haapasalo, Jaakko Huovinen
Publikováno v:
Journal of Alzheimer's Disease. 43:565-573
BACKGROUND Several risk loci for Alzheimer's disease (AD) have been identified during recent years in large-scale genome-wide association studies. However, little is known about the mechanisms by which these loci influence AD pathogenesis. OBJECTIVE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb52bb79515c9cabfab4d4dfcb8a0ff
https://doi.org/10.3233/jad-140777
https://doi.org/10.3233/jad-140777
Autor:
Sanna-Kaisa Herukka, Hilkka Soininen, Viljami Väisänen, Anette Hall, Seppo Helisalmi, Marjo Laitinen, Anne M. Koivisto, Esa-Heikki Meriläinen, Mikko Hiltunen
Publikováno v:
Neurodegenerative Diseases. 14:204-208
Background: Poly-T repeat lengths of rs10524523 in TOMM40 together with APOE polymorphism have been reported to affect the risk of late-onset Alzheimer's disease (LOAD) and the age of onset (AOO). Objective: To explore whether the AOO and cerebrospin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84804876ba524206c2e7706e40523981
https://doi.org/10.1159/000367994
https://doi.org/10.1159/000367994
Autor:
Marjo Laitinen, Jussi Paananen, Seppo Helisalmi, Tuomas Rauramaa, Juha E. Jääskeläinen, Ville Leinonen, Joel Huovinen, Annakaisa Haapasalo, Mikko Hiltunen, Anne M. Remes, Irina Alafuzoff, Timo Sarajärvi, Tiina Laiterä, Hilkka Soininen
Publikováno v:
Journal of Alzheimer's disease : JAD. 55(3)
Background Idiopathic normal pressure hydrocephalus (iNPH) is a dementing condition featuring characteristic symptoms, ventriculomegaly, and normal or slightly elevated cerebrospinal fluid pressure. In Alzheimer's disease (AD) patients, diffuse aggre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83eb28f9f709af8a2ef620d28a325223
https://pubmed.ncbi.nlm.nih.gov/27802227
https://pubmed.ncbi.nlm.nih.gov/27802227
Autor:
Seppo Helisalmi, Timo Sarajärvi, Hilkka Soininen, Ulla E. Petäjä-Repo, Petra Mäkinen, Tarja Kauppinen, Mikko Hiltunen, Annakaisa Haapasalo, Teemu Natunen, Tuomas Rauramaa, Mikael Marttinen, Ville Leinonen, Marjo Laitinen
Publikováno v:
Journal of Alzheimer's disease : JAD. 48(2)
The agonist-induced activation of human δ-opioid receptor (δOR) has been shown to increase β- (BACE1) and γ-secretase activities leading to increased production of amyloid-β (Aβ) peptide. We have recently shown that phenylalanine to cysteine su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bafb9cf0730fcc194e17cba99d1acdbd
https://pubmed.ncbi.nlm.nih.gov/26402014
https://pubmed.ncbi.nlm.nih.gov/26402014