Výsledky vyhledávání - "Marjia Afrin"

Akademický článek

The RRM-mediated RNA binding activity in T. brucei RAP1 is essential for VSG monoallelic expression

Autor: Amit Kumar Gaurav, Marjia Afrin, Xian Yang, Arpita Saha, S. K. Abdus Sayeed, Xuehua Pan, Zeyang Ji, Kam-Bo Wong, Mingjie Zhang, Yanxiang Zhao, Bibo Li

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Monoallelic VSG expression is essential for Trypanosoma brucei survival. Competition between TbRAP1’s RNA and dsDNA binding activities ensures that TbRAP1 sustains a high level expression of the active VSG while silencing other VSGs globally.

Externí odkaz: https://doaj.org/article/91066c3cb921440d867f7769d1f29746

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Akademický článek

Trypanosoma brucei RAP1 Has Essential Functional Domains That Are Required for Different Protein Interactions

Autor: Marjia Afrin, Hanadi Kishmiri, Ranjodh Sandhu, M. A. G. Rabbani, Bibo Li

Publikováno v: mSphere, Vol 5, Iss 1 (2020)

ABSTRACT RAP1 is a telomere protein that is well conserved from protozoa to mammals. It plays important roles in chromosome end protection, telomere length control, and gene expression/silencing at both telomeric and nontelomeric loci. Interaction wi

Externí odkaz: https://doaj.org/article/80c4e73956134255abe3a3f04b1cd2ba

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Identification of Prazosin as a Potential Flagellum Attachment Zone 1(FAZ1) Inhibitor for the Treatment of Human African Trypanosomiasis

Autor: Cody M. Orahoske, Marjia Afrin, Yaxin Li, Jovana Hanna, Myah Marbury, Bibo Li, Bin Su

Publikováno v: ACS infectious diseases. 8(8)

Human African trypanosomiasis (HAT) remains a health threat to sub-Saharan Africa. The current treatments suffer from drug resistance and life-threatening side effects, making drug discovery for HAT still important. A high-throughput screening of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2a104c08c66f4efaa57743f2ad88aae
https://pubmed.ncbi.nlm.nih.gov/35894227

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TbTRF suppresses the TERRA level and regulates the cell cycle-dependent TERRA foci number with a TERRA binding activity in its C-terminal Myb domain

Autor: Amit Kumar Gaurav, Marjia Afrin, Arpita Saha, Unnati M. Pandya, Ranjodh Sandhu, Bibo Li, Brittny Schnur, Vishal Nanavaty

Publikováno v: Nucleic Acids Research

Telomere repeat-containing RNA (TERRA) has been identified in multiple organisms including Trypanosoma brucei, a protozoan parasite that causes human African trypanosomiasis. T. brucei regularly switches its major surface antigen, VSG, to evade the h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf318b82767cf5a5fc412ddf553ecd5
https://doi.org/10.1093/nar/gkab401

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Synthesis and biological evaluation of imidamide analogs as selective anti-trypanosomal agents

Autor: Viharika Bobba, Yaxin Li, Marjia Afrin, Raina Dano, Wenjing Zhang, Bibo Li, Bin Su

Publikováno v: Bioorg Med Chem

Human African trypanosomiasis is caused by a protozoan parasite Trypanosoma brucei majorly infecting people living in sub-Saharan Africa. Current limited available treatments suffer from drug resistance, severe adverse effects, low efficacy, and cost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d572b40c7d9e3dfeb4ce312994b86b3
https://pubmed.ncbi.nlm.nih.gov/35396128

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Trypanosoma bruceiPolIE suppresses telomere recombination

Autor: Tonini M, Rabbani Mag, Marjia Afrin, Bibo Li

Telomeres are essential for genome integrity and stability. InT. bruceithat causes human African trypanosomiasis, the telomere structure and telomere proteins also influence the virulence of the parasite, as its major surface antigen involved in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::906d82571ac5dbef70855eedc520111a
https://doi.org/10.1101/2021.05.07.443201

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Tb RAP1 has an unusual duplex DNA binding activity required for its telomere localization and VSG silencing

Autor: Marjia Afrin, Amit Kumar Gaurav, Yanxiang Zhao, Xuehua Pan, Bibo Li, Xian Yang

Publikováno v: Science Advances

The electrostatics-based dsDNA binding activity in TbRAP1 NLS can be diminished by phosphorylation of NLS-adjacent S residues.
Localization of Repressor Activator Protein 1 (RAP1) to the telomere is essential for its telomeric functions. RAP1 ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bae522f191c5b0e7710fba9f49954de
https://doi.org/10.1126/sciadv.abc4065

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Trypanosoma brucei RAP1 Has Essential Functional Domains That Are Required for Different Protein Interactions

Autor: Marjia Afrin, M. A. G. Rabbani, Hanadi Kishmiri, Ranjodh Sandhu, Bibo Li

Publikováno v: mSphere, Vol 5, Iss 1 (2020)
mSphere, Vol 5, Iss 1, p e00027-20 (2020)
mSphere

Trypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen, VSG, to evade the host immune response. VSGs are expressed from subtelomeres in a monoallelic fashion. TbRAP1, a telomere protein, is essential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::439c6f5806cd6941016e0d8f428c2777
https://journals.asm.org/doi/10.1128/mSphere.00027-20

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