Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Marjet Elemans"'
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 2, p e1005954 (2018)
Tumors consist of a hierarchical population of cells that differ in their phenotype and genotype. This hierarchical organization of cells means that a few clones (i.e., cells and several generations of offspring) are abundant while most are rare, whi
Externí odkaz:
https://doaj.org/article/dd648e88c26c416ba1d89756a7664d38
Publikováno v:
PLoS Pathogens, Vol 13, Iss 6, p e1006361 (2017)
The observation, by Alter et al., of the enrichment of NK cell "escape" variants in individuals carrying certain Killer-cell Immunoglobulin-like Receptor (KIR) genes is compelling evidence that natural killer (NK) cells exert selection pressure on HI
Externí odkaz:
https://doaj.org/article/83d6fdebebdc4d27862868f00c692c63
Autor:
Raya Ahmed, Liset Westera, Julia Drylewicz, Marjet Elemans, Yan Zhang, Elizabeth Kelly, Rajko Reljic, Kiki Tesselaar, Rob J de Boer, Derek C Macallan, José A M Borghans, Becca Asquith
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 10, p e1004355 (2015)
Stable isotope labeling is the state of the art technique for in vivo quantification of lymphocyte kinetics in humans. It has been central to a number of seminal studies, particularly in the context of HIV-1 and leukemia. However, there is a signific
Externí odkaz:
https://doaj.org/article/788648ec6be942418a8b6745f1109b62
Autor:
Stina L. Wickström, Arnika K. Wagner, Sina Fuchs, Marjet Elemans, Joanna Kritikou, Ramit Mehr, Klas Kärre, Maria H. Johansson, Hanna Brauner
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 209(4)
MHC class I (MHC I) expression in the host influences NK cells in a process termed education. The result of this education is reflected in the responsiveness of NK cells at the level of individual cells as well as in the repertoire of inhibitory MHC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079372cb326043780c7b7e675df2744a
https://pubmed.ncbi.nlm.nih.gov/35896339
https://pubmed.ncbi.nlm.nih.gov/35896339
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 4, p e1003534 (2014)
The CD8+ cytotoxic T lymphocyte (CTL) response is an important defence against viral invasion. Although CTL-mediated cytotoxicity has been widely studied for many years, the rate at which virus-infected cells are killed in vivo by the CTL response is
Externí odkaz:
https://doaj.org/article/d8ce1ef210274687b0a5947dad0a0374
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 2, p e1002381 (2012)
Multidisciplinary techniques, in particular the combination of theoretical and experimental immunology, can address questions about human immunity that cannot be answered by other means. From the turnover of virus-infected cells in vivo, to rates of
Externí odkaz:
https://doaj.org/article/c9836550470d4752b9eb0eca245a7008
Autor:
Marjet Elemans, Nafisa-Katrin Seich Al Basatena, Nichole R Klatt, Christos Gkekas, Guido Silvestri, Becca Asquith
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 9, p e1002200 (2011)
In January 2010 two groups independently published the observation that the depletion of CD8+ cells in SIV-infected macaques had no detectable impact on the lifespan of productively infected cells. This unexpected observation led the authors to sugge
Externí odkaz:
https://doaj.org/article/30895709fb3e4d4c94e05ec27e9dfca4
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 3, p e1001103 (2011)
CD8+ cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, B cells and target cell limitation have all been suggested to play a role in the control of SIV and HIV-1 infection. However, previous research typically studied each population in isola
Externí odkaz:
https://doaj.org/article/a3218da20eb447f9a64c67090ca6d76d
Autor:
Arafa Salam, Yan Zhang, Becca Asquith, Christoph Niederalt, Michael Block, Marjet Elemans, Julio Lahoz-Beneytez, Derek C. Macallan, Raya Ahmed
Publikováno v:
Blood. 127:3431-3438
Human neutrophils have traditionally been thought to have a short half-life in blood; estimates vary from 4 to 18 hours. This dogma was recently challenged by stable isotope labeling studies with heavy water, which yielded estimates in excess of 3 da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937ee12d51a26a2ff945fbc6120f4a55
https://doi.org/10.1182/blood-2016-03-700336
https://doi.org/10.1182/blood-2016-03-700336
Publikováno v:
Virology. 435:131-140
ContentsIntroduction. . 131HTLV-1 pathogenesis 132HTLV-1 and disease. . . 132ATL 132HAM/TSP . . 132Determinants of proviral load 132Integration and clonal expansion . . 132CD8þ T cell lysis 133The immune response to HTLV-1. . . 133Determinants of pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da6492b4f7f37466b7e5f287e79357c
https://doi.org/10.1016/j.virol.2012.09.028
https://doi.org/10.1016/j.virol.2012.09.028