A combination of a cell penetrating peptide and a protein translation inhibitor kills metastatic breast cancer cells.

Autor: Rowland L; Department of Surgery, University of Missouri School of Medicine, Christopher S. Bond Life Sciences Center University of Missouri, 1201 Rollins Street, Columbia, MO, 65201, USA., Marjault HB; Department of Surgery, University of Missouri School of Medicine, Christopher S. Bond Life Sciences Center University of Missouri, 1201 Rollins Street, Columbia, MO, 65201, USA., Karmi O; The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem, 9190401, Israel., Grant D; Electron Microscopy Core Facility, University of Missouri, 0011 NextGen Precision Health Institute, 1030 Hitt Street, Columbia, MO, 65211, USA., Webb LJ; Department of Chemistry, The University of Texas at Austin, 2506 Speedway STOP A5300, Austin, TX, 78712, USA., Friedler A; Institute of Chemistry, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem, 9190401, Israel., Nechushtai R; The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem, 9190401, Israel., Elber R; Institute for Computational Engineering and Science and Department of Chemistry, University of Texas at Austin, Austin, TX, 78712, USA., Mittler R; Department of Surgery, University of Missouri School of Medicine, Christopher S. Bond Life Sciences Center University of Missouri, 1201 Rollins Street, Columbia, MO, 65201, USA. mittlerr@missouri.edu.

Publikováno v: Cell death discovery [Cell Death Discov] 2023 Aug 31; Vol. 9 (1), pp. 325. Date of Electronic Publication: 2023 Aug 31.

Structure-Based Screening Reveals a Ligand That Stabilizes the [2Fe-2S] Clusters of Human mitoNEET and Reduces Ovarian Cancer Cell Proliferation.

Autor: Marjault HB; The Alexander Silberman Institute of Life Science and The Wolfson Centre for Applied Structural Biology, Faculty of Science and Mathematics, The Edmond J. Safra Campus at Givat Ram, The Hebrew University of Jerusalem, Jerusalem91904, Israel.; Department of Physics, RWTH Aachen University, 52074Aachen, Germany., Yang-Sung S; The Alexander Silberman Institute of Life Science and The Wolfson Centre for Applied Structural Biology, Faculty of Science and Mathematics, The Edmond J. Safra Campus at Givat Ram, The Hebrew University of Jerusalem, Jerusalem91904, Israel., Zuo K; The Alexander Silberman Institute of Life Science and The Wolfson Centre for Applied Structural Biology, Faculty of Science and Mathematics, The Edmond J. Safra Campus at Givat Ram, The Hebrew University of Jerusalem, Jerusalem91904, Israel.; Department of Physics, RWTH Aachen University, 52074Aachen, Germany., Carloni P; Department of Physics, RWTH Aachen University, 52074Aachen, Germany.; Computational Biomedicine Section, Institute of Advanced Simulation IAS-5 and Institute of Neuroscience and Medicine INM-9, Forschungszentrum Jülich GmbH, 52425Jülich, Germany.; Computational Biomedicine, Institute of Advanced Simulation IAS-5 and Institute of Neuroscience and Medicine INM-9, Forschungszentrum Jülich GmbH, 52425Jülich, Germany.; JARA Institute: Molecular Neuroscience and Imaging, Institute of Neuroscience and Medicine INM-11, Forschungszentrum Jülich GmbH, 52425Jülich, Germany., Mittler R; Department of Surgery, University of Missouri School of Medicine, and Interdisciplinary Plant Group, Christopher S. Bond Life Sciences Center, University of Missouri, 1201 Rollins Street, Columbia, Missouri65211, United States., Nechushtai R; The Alexander Silberman Institute of Life Science and The Wolfson Centre for Applied Structural Biology, Faculty of Science and Mathematics, The Edmond J. Safra Campus at Givat Ram, The Hebrew University of Jerusalem, Jerusalem91904, Israel.

Publikováno v: The journal of physical chemistry. B [J Phys Chem B] 2022 Nov 24; Vol. 126 (46), pp. 9559-9565. Date of Electronic Publication: 2022 Nov 14.

An anti-diabetic drug targets NEET (CISD) proteins through destabilization of their [2Fe-2S] clusters.

Autor: Marjault HB; The Alexander Silberman Institute of Life Science and The Wolfson Centre for Applied Structural Biology, Faculty of Science and Mathematics, The Edmond J. Safra Campus at Givat Ram, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.; Department of Physics, RWTH Aachen University, 52074, Aachen, Germany., Karmi O; The Alexander Silberman Institute of Life Science and The Wolfson Centre for Applied Structural Biology, Faculty of Science and Mathematics, The Edmond J. Safra Campus at Givat Ram, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.; Department of Surgery, University of Missouri School of Medicine, and Interdisciplinary Plant Group, Christopher S. Bond Life Sciences Center, University of Missouri, 1201 Rollins St, Columbia, MO, 65211, USA., Zuo K; The Alexander Silberman Institute of Life Science and The Wolfson Centre for Applied Structural Biology, Faculty of Science and Mathematics, The Edmond J. Safra Campus at Givat Ram, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.; Department of Physics, RWTH Aachen University, 52074, Aachen, Germany., Michaeli D; The Alexander Silberman Institute of Life Science and The Wolfson Centre for Applied Structural Biology, Faculty of Science and Mathematics, The Edmond J. Safra Campus at Givat Ram, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel., Eisenberg-Domovich Y; The Alexander Silberman Institute of Life Science and The Wolfson Centre for Applied Structural Biology, Faculty of Science and Mathematics, The Edmond J. Safra Campus at Givat Ram, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel., Rossetti G; Department of Physics, RWTH Aachen University, 52074, Aachen, Germany.; Computational Biomedicine Section, Institute of Advanced Simulation IAS-5 and Institute of Neuroscience and Medicine INM-9, Forschungszentrum Jülich GmbH, 52425, Jülich, Germany.; Computational Biomedicine, Institute of Advanced Simulation IAS-5 and Institute of Neuroscience and Medicine INM-9, For-schungszentrum Jülich GmbH, 52425, Jülich, Germany., de Chassey B; ENYO-Pharma, Bioserra 1, 60 Avenue Rockefeller Bâtiment B, 69008, Lyon, France., Vonderscher J; ENYO-Pharma, Bioserra 1, 60 Avenue Rockefeller Bâtiment B, 69008, Lyon, France., Cabantchik I; The Alexander Silberman Institute of Life Science and The Wolfson Centre for Applied Structural Biology, Faculty of Science and Mathematics, The Edmond J. Safra Campus at Givat Ram, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel., Carloni P; Department of Physics, RWTH Aachen University, 52074, Aachen, Germany.; Computational Biomedicine Section, Institute of Advanced Simulation IAS-5 and Institute of Neuroscience and Medicine INM-9, Forschungszentrum Jülich GmbH, 52425, Jülich, Germany.; Computational Biomedicine, Institute of Advanced Simulation IAS-5 and Institute of Neuroscience and Medicine INM-9, For-schungszentrum Jülich GmbH, 52425, Jülich, Germany.; JARA Institute: Molecular Neuroscience and Imaging, Institute of Neuroscience and Medicine INM-11, Forschungszentrum Jülich GmbH, 52425, Jülich, Germany., Mittler R; Department of Surgery, University of Missouri School of Medicine, and Interdisciplinary Plant Group, Christopher S. Bond Life Sciences Center, University of Missouri, 1201 Rollins St, Columbia, MO, 65211, USA., Livnah O; The Alexander Silberman Institute of Life Science and The Wolfson Centre for Applied Structural Biology, Faculty of Science and Mathematics, The Edmond J. Safra Campus at Givat Ram, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel., Meldrum E; ENYO-Pharma, Bioserra 1, 60 Avenue Rockefeller Bâtiment B, 69008, Lyon, France., Nechushtai R; The Alexander Silberman Institute of Life Science and The Wolfson Centre for Applied Structural Biology, Faculty of Science and Mathematics, The Edmond J. Safra Campus at Givat Ram, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel. Rachel@mail.huji.ac.il.

Publikováno v: Communications biology [Commun Biol] 2022 May 10; Vol. 5 (1), pp. 437. Date of Electronic Publication: 2022 May 10.

Cadmium interference with iron sensing reveals transcriptional programs sensitive and insensitive to reactive oxygen species.

Autor: McInturf SA; Division of Plant Sciences, C.S. Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA., Khan MA; Division of Plant Sciences, C.S. Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA., Gokul A; Environmental Biotechnology Laboratory, Department of Biotechnology, University of the Western Cape, Bellville, Cape Town, 7535, South Africa., Castro-Guerrero NA; Division of Plant Sciences, C.S. Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA., Höhner R; School of Biological Sciences, Washington State University, PO Box 644236, Pullman, WA 99164-4236, USA., Li J; Department of Entomology and Plant Pathology, 217 Plant Sciences Building, University of Arkansas System Division of Agriculture, Fayetteville, AR 72701, USA., Marjault HB; Institute of Life Science, The Hebrew University of Jerusalem, Jerusalem, 91904Israel., Fichman Y; Division of Plant Sciences, C.S. Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA., Kunz HH; School of Biological Sciences, Washington State University, PO Box 644236, Pullman, WA 99164-4236, USA.; Biozentrum der LMU München, Germany., Goggin FL; Department of Entomology and Plant Pathology, 217 Plant Sciences Building, University of Arkansas System Division of Agriculture, Fayetteville, AR 72701, USA., Keyster M; Environmental Biotechnology Laboratory, Department of Biotechnology, University of the Western Cape, Bellville, Cape Town, 7535, South Africa., Nechushtai R; Institute of Life Science, The Hebrew University of Jerusalem, Jerusalem, 91904Israel., Mittler R; Division of Plant Sciences, C.S. Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA., Mendoza-Cózatl DG; Division of Plant Sciences, C.S. Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA.; Environmental Biotechnology Laboratory, Department of Biotechnology, University of the Western Cape, Bellville, Cape Town, 7535, South Africa.

Publikováno v: Journal of experimental botany [J Exp Bot] 2022 Jan 05; Vol. 73 (1), pp. 324-338.

A Combined Drug Treatment That Reduces Mitochondrial Iron and Reactive Oxygen Levels Recovers Insulin Secretion in NAF-1-Deficient Pancreatic Cells.

Autor: Karmi O; The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 91904, Israel., Sohn YS; The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 91904, Israel., Marjault HB; The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 91904, Israel., Israeli T; School of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel., Leibowitz G; School of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.; Endocrinology and Metabolism Service, Hadassah Medical Center, Jerusalem 9112102, Israel., Ioannidis K; The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 91904, Israel.; Alexander Grass Center for Bioengineering, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 91904, Israel., Nahmias Y; The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 91904, Israel.; Alexander Grass Center for Bioengineering, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 91904, Israel., Mittler R; Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65201, USA., Cabantchik IZ; The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 91904, Israel., Nechushtai R; The Alexander Silberman Institute of Life Science, The Hebrew University of Jerusalem, Edmond J. Safra Campus at Givat Ram, Jerusalem 91904, Israel.

Publikováno v: Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2021 Jul 21; Vol. 10 (8). Date of Electronic Publication: 2021 Jul 21.