Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Marjan Shayegan"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Multi-step assembly of individual protein building blocks is key to the formation of essential higher-order structures inside and outside of cells. Optical tweezers is a technique well suited to investigate the mechanics and dynamics of these structu
Externí odkaz:
https://doaj.org/article/318e158d9a7444f5b28fe1624b86be8e
Autor:
Marjan Shayegan, Nancy R Forde
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70590 (2013)
Collagen is the most abundant protein in the extracellular matrix (ECM), where its structural organization conveys mechanical information to cells. Using optical-tweezers-based microrheology, we investigated mechanical properties both of collagen mol
Externí odkaz:
https://doaj.org/article/d071a2f493e740b38c1fe77274560504
Publikováno v:
Soft Matter. 18:5359-5365
In the past three decades, the technology of optical tweezers has made significant contributions in various scientific areas, including optics, photonics, and nanosciences. Breakthroughs include manipulating particles in both static and dynamic ways,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2f619fe4748c23fd7fbeeb6111075c9
https://doi.org/10.1039/d2sm00259k
https://doi.org/10.1039/d2sm00259k
Autor:
Zhiyue Zhang, Albert Kamanzi, Kimberly Metera, Cynthia Shaheen, Daniel Berard, Radin Tahvildari, Sabrina Leslie, Shane Scott, Marjan Shayegan
Publikováno v:
Current Opinion in Biomedical Engineering. 12:75-82
Molecular biology is messy and complex. The future of life sciences research, drug development, and many fields depends on our ability to unravel the complex, biophysical phenomena that underlie cellular function with a finer level of resolution. Usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fd6ec07d48340f0ec8cc9b373d98fc2
https://doi.org/10.1016/j.cobme.2019.10.004
https://doi.org/10.1016/j.cobme.2019.10.004
Autor:
Liheng Cai, Huayin Wu, Meng Zhang, Dianzhuo Wang, Hui Li, Yinan Shen, Robert D. Goldman, Arturo Moncho-Jordá, Jing Xia, Fred C. MacKintosh, Weichao Shi, Marjan Shayegan, Ruihua Ding, Harald Herrmann, David A. Weitz, Peter J. Lu, Zizhao Wang
Publikováno v:
Physical Review Letters. 127
We investigate the rheological properties of interpenetrating networks reconstituted from the main cytoskeletal components: filamentous actin, microtubules, and vimentin intermediate filaments. The elastic modulus is determined largely by actin, with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cae636e380b17082a54844ba9adaa70
https://doi.org/10.1103/physrevlett.127.108101
https://doi.org/10.1103/physrevlett.127.108101
Autor:
Stephen W. Michnick, Marjan Shayegan, Kimberly Metera, Lydia Kisley, Radin Tahvildari, Sabrina Leslie
Publikováno v:
Journal of the American Chemical Society. 141:7751-7757
Biopolymer condensates formed by liquid-liquid phase separation of proteins and nucleic acids have been recently discovered to be prevalent in biology. These dynamic condensates behave like biochemical reaction vessels but little is known about their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df5060a65901da791bfe4f359d98fbc9
https://doi.org/10.1021/jacs.8b13349
https://doi.org/10.1021/jacs.8b13349
Publikováno v:
Analytical Chemistry. 88:11100-11107
We present a dynamically adjustable nanofluidic platform for formatting the conformations of and visualizing the interaction kinetics between biomolecules in solution, offering new time resolution and control of the reaction processes. This platform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5a63d2d15c3a2567362237552a7ff5
https://doi.org/10.1021/acs.analchem.6b03149
https://doi.org/10.1021/acs.analchem.6b03149
Publikováno v:
Biophysical journal. 111(11)
Collagen is the fundamental structural component of a wide range of connective tissues and of the extracellular matrix. It undergoes self-assembly from individual triple-helical proteins into well-ordered fibrils, a process that is key to tissue deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a02826efd3547c9f593f392a2a67a9c
https://pubmed.ncbi.nlm.nih.gov/27926842
https://pubmed.ncbi.nlm.nih.gov/27926842
Publikováno v:
Scopus-Elsevier
The local viscoelasticity was compared between full-length and telopeptide-removed collagen solutions using optical-tweezers-based microrheology. An enhanced modulus at higher concentrations in full-length collagen solutions suggests contributions fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b4d31e60f83ffa91c75bcf16a2c904
https://doi.org/10.1364/ota.2015.otm3e.3
https://doi.org/10.1364/ota.2015.otm3e.3
Publikováno v:
Biophysical Journal. 106(2)
Collagen is the predominant protein in vertebrates, where it comprises more than 1/4 of the total protein and performs structural and mechanical tasks in the extracellular matrix and connective tissues. Formed intracellularly as a triple helical prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270ab3cdb613bd94c14401da0ef05610