Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Marjan Rafat"'
Publikováno v:
Journal of Bone Oncology, Vol 45, Iss , Pp 100561- (2024)
Externí odkaz:
https://doaj.org/article/e2ee24c26fb047fc9c5a5a9620bff39b
Publikováno v:
Frontiers in Biomaterials Science, Vol 2 (2023)
Bone metastasis is highly prevalent in breast cancer patients with metastatic disease. These metastatic cells may eventually form osteolytic lesions and affect the integrity of the bone, causing pathological fractures and impairing patient quality of
Externí odkaz:
https://doaj.org/article/4c53c7356753477ea7e71074e627e554
Autor:
Javier Cifuentes, Santiago Cifuentes-Almanza, Paola Ruiz Puentes, Valentina Quezada, Andrés Fernando González Barrios, María-Angélica Calderón-Peláez, Myriam Lucia Velandia-Romero, Marjan Rafat, Carolina Muñoz-Camargo, Sonia L. Albarracín, Juan C. Cruz
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease. Therefore, development of novel technologies and strategies to treat PD is a global health priority. Current treatments include administratio
Externí odkaz:
https://doaj.org/article/09008c2b741541f4b10190339c16a3d6
Publikováno v:
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-18 (2021)
Abstract Intercellular communication is a critical process that ensures cooperation between distinct cell types and maintains homeostasis. EVs, which were initially described as cellular debris and devoid of biological function, are now recognized as
Externí odkaz:
https://doaj.org/article/6a1db8bdeec6453db2842e0373af27b8
Autor:
Vera M. Todd, Lawrence A. Vecchi, Miranda E. Clements, Katherine P. Snow, Cayla D. Ontko, Lauren Himmel, Christopher Pinelli, Marjan Rafat, Rachelle W. Johnson
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-18 (2021)
Todd et al employ a PyMT-driven spontaneous murine mammary carcinoma model with mammary-specific deletion of hypoxia inducible factors Hif1α, Hif2α, or von Hippel-Lindau factor to further investigate their role in bone and lung metastasis. They fin
Externí odkaz:
https://doaj.org/article/975f1c09009840709de77452a7dc73cb
Autor:
Eui Jung Moon, Stephano S. Mello, Caiyun G. Li, Jen-Tsan Chi, Kaushik Thakkar, Jacob G. Kirkland, Edward L. Lagory, Ik Jae Lee, Anh N. Diep, Yu Miao, Marjan Rafat, Marta Vilalta, Laura Castellini, Adam J. Krieg, Edward E. Graves, Laura D. Attardi, Amato J. Giaccia
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Hypoxia plays a critical role in tumor progression including invasion and metastasis. Here, the authors screened several hypoxia inducible genes and identified the oncogenic role of MAFF in breast cancer metastasis and that it activates IL11/STAT3 pa
Externí odkaz:
https://doaj.org/article/74a0bdf041f848a69bf653962a2ec1b4
Autor:
Karen Levy, Suchitra Natarajan, Jinghui Wang, Stephanie Chow, Joshua T. Eggold, Phoebe E. Loo, Rakesh Manjappa, Stavros Melemenidis, Frederick M. Lartey, Emil Schüler, Lawrie Skinner, Marjan Rafat, Ryan Ko, Anna Kim, Duaa H. Al-Rawi, Rie von Eyben, Oliver Dorigo, Kerriann M. Casey, Edward E. Graves, Karl Bush, Amy S. Yu, Albert C. Koong, Peter G. Maxim, Billy W. Loo, Erinn B. Rankin
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract Radiation therapy is the most effective cytotoxic therapy for localized tumors. However, normal tissue toxicity limits the radiation dose and the curative potential of radiation therapy when treating larger target volumes. In particular, the
Externí odkaz:
https://doaj.org/article/e19427aedbeb4ad9ab2df08481282096
Autor:
Katrina M. Wisdom, Kolade Adebowale, Julie Chang, Joanna Y. Lee, Sungmin Nam, Rajiv Desai, Ninna Struck Rossen, Marjan Rafat, Robert B. West, Louis Hodgson, Ovijit Chaudhuri
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
In order to metastasize, cancer cells must migrate through basement membranes and dense stroma, and proteases are thought to be required due to the confining nature of these matrices. Here the authors use synthetic matrices to show that cells can mig
Externí odkaz:
https://doaj.org/article/98c929b92b67496b9f803a21d27ece3c
Autor:
Sharareh Gholamin, Osama A Youssef, Marjan Rafat, Rogelio Esparza, Suzana Kahn, Maryam Shahin, Amato J Giaccia, Edward E Graves, Irving Weissman, Siddhartha Mitra, Samuel H Cheshier
Publikováno v:
Innate Immunity, Vol 26 (2020)
Irradiation and temozolomide (TMZ) chemotherapy are the current standard treatments for glioblastoma multiforme (GBM), but they are associated with toxicity and limited efficacy. Recently, these standard therapies have been used to enhance immunother
Externí odkaz:
https://doaj.org/article/3330de0f84114cf79de9647eea0489bb
Autor:
Todd A. Aguilera, Marjan Rafat, Laura Castellini, Hussein Shehade, Mihalis S. Kariolis, Angela Bik-Yu Hui, Henning Stehr, Rie von Eyben, Dadi Jiang, Lesley G. Ellies, Albert C. Koong, Maximilian Diehn, Erinn B. Rankin, Edward E. Graves, Amato J. Giaccia
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Radiotherapy can enhance the antitumour immune response. Here, the authors show that resistance to radiation in breast cancer cells can be due to Axl expression that suppresses antigen presentation though MHCI, promotes NF-κB signalling, and enhance
Externí odkaz:
https://doaj.org/article/d32eb98fd69f4bdf897a2cd00a59903c