RNA nanostructures for targeted drug delivery and imaging

Autor: Laura Teodori, Marjan Omer, Jørgen Kjems

Publikováno v: RNA Biology, Vol 21, Iss 1, Pp 1-19 (2024)

ABSTRACTThe RNA molecule plays a pivotal role in many biological processes by relaying genetic information, regulating gene expression, and serving as molecular machines and catalyzers. This inherent versatility of RNA has fueled significant advancem

Externí odkaz: https://doaj.org/article/1d8feccf03d64ba78314c62d4b2d1973

Antigen footprint governs activation of the B cell receptor

Autor: Alexey Ferapontov, Marjan Omer, Isabelle Baudrexel, Jesper Sejrup Nielsen, Daniel Miotto Dupont, Kristian Juul-Madsen, Philipp Steen, Alexandra S. Eklund, Steffen Thiel, Thomas Vorup-Jensen, Ralf Jungmann, Jørgen Kjems, Søren Egedal Degn

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)

The antigen-B-cell-receptor interaction is the driving force of terminal B cell development that spans from B cell activation to antibody secreting plasma cells. Here authors determine, using DNA-PAINT super-resolution microscopy, how antigen affinit

Externí odkaz: https://doaj.org/article/7f869c05d1344a178551b817ab0ce76e

Biased activation of the receptor tyrosine kinase HER2

Autor: Claudia Catapano, Johanna V. Rahm, Marjan Omer, Laura Teodori, Jørgen Kjems, Marina S. Dietz, Mike Heilemann

Publikováno v: Catapano, C, Rahm, J V, Omer, M, Teodori, L, Kjems, J, Dietz, M S & Heilemann, M 2023, ' Biased activation of the receptor tyrosine kinase HER2 ', Cellular and Molecular Life Sciences, vol. 80, no. 6, 158 . https://doi.org/10.1007/s00018-023-04806-8

HER2 belongs to the ErbB sub-family of receptor tyrosine kinases and regulates cellular proliferation and growth. Different from other ErbB receptors, HER2 has no known ligand. Activation occurs through heterodimerization with other ErbB receptors an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e4b53ae75bfac5b2c1b51ff73ad41a
https://pure.au.dk/portal/da/publications/biased-activation-of-the-receptor-tyrosine-kinase-her2(29f97c3f-30cc-4644-b874-089e033cca5c).html

Improved Cancer Targeting by Multimerizing Aptamers on Nanoscaffolds

Autor: Jesper Sejrup Nielsen, Jesper Wengel, Veronica Liv Andersen, Jørgen Kjems, Marjan Omer

Publikováno v: Omer, M, Andersen, V L, Nielsen, J S, Wengel, J & Kjems, J 2020, ' Improved Cancer Targeting by Multimerizing Aptamers on Nanoscaffolds ', Molecular Therapy-Nucleic Acids, vol. 22, pp. 994-1003 . https://doi.org/10.1016/j.omtn.2020.10.013
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 22, Iss, Pp 994-1003 (2020)

Aptamers are short single-stranded oligonucleotides selected to bind with high affinity and specificity to a target. In contrast to antibodies, aptamers can be produced in large-scale in vitro systems without the need for any biological agents, makin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8adaa536b2ba92d205fe1770220290aa
https://findresearcher.sdu.dk:8443/ws/files/174846011/PIIS2162253120303255.pdf

Molecular requirements for B cell receptor engagement and activation

Autor: Alexey Ferapontov, Marjan Omer, Jesper Nielsen, Steffen Thiel, Jørgen Kjems, Søren Egedal Degn

Publikováno v: The Journal of Immunology. 204:217.20-217.20

B cells are a central component of the adaptive branch of the immune system, responsible for humoral immunity through production of antibodies. Antigen engagement of the B cell receptor (BCR) is the first step in B cell activation; yet despite its re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bfb0dafc2531f2587459f665436a401b
https://doi.org/10.4049/jimmunol.204.supp.217.20