Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Marjan Azin"'
Autor:
Jong Ho Park, Mahsa Mortaja, Heehwa G. Son, Xutu Zhao, Lauren M. Sloat, Marjan Azin, Jun Wang, Michael R. Collier, Krishna S. Tummala, Anna Mandinova, Nabeel Bardeesy, Yevgeniy R. Semenov, Mari Mino-Kenudson, Shadmehr Demehri
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Chronic inflammation is a major cause of cancer worldwide. Interleukin 33 (IL-33) is a critical initiator of cancer-prone chronic inflammation; however, its induction mechanism by environmental causes of chronic inflammation is unknown. Here
Externí odkaz:
https://doaj.org/article/e2b006d3a3b94b3d96580a3db87ec074
Publikováno v:
JID Innovations, Vol 3, Iss 6, Pp 100221- (2023)
Nonkeratinocyte cutaneous malignancies, including breast cancer cutaneous metastasis and melanoma in situ, are often poor surgical candidates. Imiquimod (IMQ), a toll-like receptor 7 agonist that activates innate immunity in the skin, is used to trea
Externí odkaz:
https://doaj.org/article/b4c9a45922ea4fc28da9b184d7de4c7b
Autor:
Mei Huang, Yun Xia, Kaiwen Li, Feng Shao, Zhaoyi Feng, Tiancheng Li, Marjan Azin, Shadmehr Demehri
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 20 (2023)
Carcinogen exposure is strongly associated with enhanced cancer immunogenicity. Increased tumor mutational burden and resulting neoantigen generation have been proposed to link carcinogen exposure and cancer immunogenicity. However, the neoantigen-in
Externí odkaz:
https://doaj.org/article/91ba86c210f54213b0ac817bd5d2ab40
Publikováno v:
JCI Insight, Vol 8, Iss 13 (2023)
Thymic stromal lymphopoietin (TSLP) overexpression is widely associated with atopy. However, TSLP is expressed in normal barrier organs, suggesting a homeostatic function. To determine the function of TSLP in barrier sites, we investigated the impact
Externí odkaz:
https://doaj.org/article/388f6bf372414502b8c89dc308e51942
Autor:
Maulik Vyas, Marta Requesens, Thao H. Nguyen, Domitille Peigney, Marjan Azin, Shadmehr Demehri
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
Despite significant advances in cancer treatment, the metastatic spread of malignant cells to distant organs remains a major cause of cancer-related deaths. Natural killer (NK) cells play a crucial role in controlling tumor metastasis; however, the d
Externí odkaz:
https://doaj.org/article/fe70b4486d334cc9a083dc96bde55ef8
Autor:
Margherita Boieri, Emanuela Marchese, Quan Minh Pham, Marjan Azin, Lauren E. Steidl, Anna Malishkevich, Shadmehr Demehri
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Thymic Stromal Lymphopoietin (TSLP) plays a prominent role in inducing type 2 immune response, commonly associated with atopic diseases. TSLP-activated CD4+ T helper 2 cells block early carcinogenesis by inducing terminal differentiation in spontaneo
Externí odkaz:
https://doaj.org/article/c799e2e102a84b92ba5cc5b2fbc12714
Autor:
Marjan Azin, Andrew B. Mahon, Steven Isaacman, Julia E. Seaman, Isabel E. Allen, Michael Szarek, Lynn A. Cornelius, Shadmehr Demehri
Publikováno v:
JID Innovations, Vol 2, Iss 3, Pp 100104- (2022)
Externí odkaz:
https://doaj.org/article/0ed6b915684f49cea61948ac8b259b9b
Autor:
Neelima Vidula, Lianne Ryan, Andrzej Niemierko, Dejan Juric, Steven J. Isakoff, Francys Verdial, Marjan Azin, Laura A. Petrillo, Beverly Moy, Leif Ellisen, Shadmehr Demehri, Aditya Bardia
Publikováno v:
Cancer Research. 83:P5-14
Background: Breast cancer associated-chest wall disease (CWD) clinically behaves in an aggressive manner. However, little is known about the genomics of CWD. Cell-free DNA (cfDNA) can identify oncogenic mutations in metastatic breast cancer (MBC). We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::217b1b065b81c2bbd001cc4134203f7f
https://doi.org/10.1158/1538-7445.sabcs22-p5-14-09
https://doi.org/10.1158/1538-7445.sabcs22-p5-14-09
Autor:
Tatsuya Hasegawa, Tomonori Oka, Heehwa G. Son, Valeria S. Oliver-García, Marjan Azin, Thomas M. Eisenhaure, David J. Lieb, Nir Hacohen, Shadmehr Demehri
Senescent cell accumulation has been implicated in the pathogenesis of aging-associated diseases including cancer. The mechanism that prevents the accumulation of senescent cells in aging human organs is unclear. Here, we demonstrate that a virus-imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90795758e1b727f52e2d7b48177a6069
https://doi.org/10.1101/2023.03.06.531282
https://doi.org/10.1101/2023.03.06.531282
Publikováno v:
Annual Review of Pathology: Mechanisms of Disease. 17:101-119
Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer, with its incidence rising steeply. Immunosuppression is a well-established risk factor for cSCC, and this risk factor highlights the critical role of the immune system in regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19016f98bc5738abae5b72b101ea7dd2
https://doi.org/10.1146/annurev-pathol-042320-120056
https://doi.org/10.1146/annurev-pathol-042320-120056