Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Marjan Van Meurs"'
Autor:
Manzhi Zhao, Ling Li, Caoimhe H. Kiernan, Melisa D. Castro Eiro, Floris Dammeijer, Marjan van Meurs, Inge Brouwers-Haspels, Merel E. P. Wilmsen, Dwin G. B. Grashof, Harmen J. G. van de Werken, Rudi W. Hendriks, Joachim G. Aerts, Yvonne M. Mueller, Peter D. Katsikis
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Cytotoxic CD8 + T cell (CTL) exhaustion is driven by chronic antigen stimulation. Reversing CTL exhaustion with immune checkpoint blockade (ICB) has provided clinical benefits in different types of cancer. We, therefore, investigated whether
Externí odkaz:
https://doaj.org/article/894d1a0cf952487080d6943e463aba2e
Autor:
Ling Li, Manzhi Zhao, Caoimhe H. Kiernan, Melisa D. Castro Eiro, Marjan van Meurs, Inge Brouwers-Haspels, Merel E. P. Wilmsen, Dwin G. B. Grashof, Harmen J. G. van de Werken, Rudi W. Hendriks, Yvonne M. Mueller, Peter D. Katsikis
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionCytotoxic CD8+ T cell (CTL) exhaustion is a dysfunctional state of T cells triggered by persistent antigen stimulation, with the characteristics of increased inhibitory receptors, impaired cytokine production and a distinct transcriptiona
Externí odkaz:
https://doaj.org/article/3847fcbb75c24886b8cbbde00a41f92f
Autor:
Yvonne M. Mueller, Thijs J. Schrama, Rik Ruijten, Marco W. J. Schreurs, Dwin G. B. Grashof, Harmen J. G. van de Werken, Giovanna Jona Lasinio, Daniel Álvarez-Sierra, Caoimhe H. Kiernan, Melisa D. Castro Eiro, Marjan van Meurs, Inge Brouwers-Haspels, Manzhi Zhao, Ling Li, Harm de Wit, Christos A. Ouzounis, Merel E. P. Wilmsen, Tessa M. Alofs, Danique A. Laport, Tamara van Wees, Geoffrey Kraker, Maria C. Jaimes, Sebastiaan Van Bockstael, Manuel Hernández-González, Casper Rokx, Bart J. A. Rijnders, Ricardo Pujol-Borrell, Peter D. Katsikis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Developing predictive methods to identify patients with high risk of severe COVID-19 disease is of crucial importance. Authors show here that by measuring anti-SARS-CoV-2 antibody and cytokine levels at the time of hospital admission and integrating
Externí odkaz:
https://doaj.org/article/8868b5c6ee1046f79b63a7f738da79df
Autor:
Manzhi Zhao, Caoimhe H Kiernan, Christopher J Stairiker, Jennifer L Hope, Leticia G Leon, Marjan van Meurs, Inge Brouwers-Haspels, Ruben Boers, Joachim Boers, Joost Gribnau, Wilfred F J van IJcken, Eric M Bindels, Remco M Hoogenboezem, Stefan J Erkeland, Yvonne M Mueller, Peter D Katsikis
Publikováno v:
PLoS Pathogens, Vol 16, Iss 6, p e1008555 (2020)
Exhaustion is a dysfunctional state of cytotoxic CD8+ T cells (CTL) observed in chronic infection and cancer. Current in vivo models of CTL exhaustion using chronic viral infections or cancer yield very few exhausted CTL, limiting the analysis that c
Externí odkaz:
https://doaj.org/article/0638732910034e3dbdc1bc9fe44b7d9d
Autor:
Christopher J Stairiker, Marjan van Meurs, Leticia G Leon, A A Brouwers-Haspels, Laurine Rijsbergen, Yvonne M Mueller, Peter D Katsikis
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0236195 (2020)
During infection, viruses enter susceptible host cells in order to replicate their components for production of new virions. In the process of infection, the gene expression of infected cells undergoes changes because of the production of viral compo
Externí odkaz:
https://doaj.org/article/a76eed523d8b44219bad60f7db5aa876
Autor:
Jennifer L. Hope, Panagiota I. Spantidea, Caoimhe H. Kiernan, Christopher J. Stairiker, Laurine C. Rijsbergen, Marjan van Meurs, Inge Brouwers-Haspels, Yvonne M. Mueller, Delia J. Nelson, Linda M. Bradley, Joachim G. J. V. Aerts, Peter D. Katsikis
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
The immune system, and in particular, cytotoxic CD8+ T cells (CTLs), plays a vital part in the prevention and elimination of tumors. In many patients, however, CTL-mediated tumor killing ultimately fails in the clearance of cancer cells resulting in
Externí odkaz:
https://doaj.org/article/244d90e4006c4431ab1b57e407dbf2cf
Autor:
Jennifer L. Hope, Manzhi Zhao, Christopher J. Stairiker, Caoimhe H. Kiernan, Alison J. Carey, Yvonne M. Mueller, Marjan van Meurs, Inge Brouwers-Haspels, Dennis C. Otero, Eun-Ah Bae, Hannah A. Faso, Alex Maas, Hans de Looper, Paolo M. Fortina, Isidore Rigoutsos, Linda M. Bradley, Stefan J. Erkeland, Peter D. Katsikis
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950), 208(3), 603-617. American Association of Immunologists
MicroRNAs (miRNAs/miRs) are small, endogenous noncoding RNAs that are important post-transcriptional regulators with clear roles in the development of the immune system and immune responses. Using miRNA microarray profiling, we characterized the expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3f2bca13f38066d8dc8b044c3fbbe6
http://www.scopus.com/inward/record.url?scp=85123567889&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85123567889&partnerID=8YFLogxK
Autor:
Jennifer L. Hope, Christopher J. Stairiker, Panagiota I. Spantidea, Donald T. Gracias, Alison J. Carey, Adam J. Fike, Marjan van Meurs, Inge Brouwers-Haspels, Laurine C. Rijsbergen, Joseph A. Fraietta, Yvonne M. Mueller, Rosemarieke C. Klop, Erietta Stelekati, E. John Wherry, Stefan J. Erkeland, Peter D. Katsikis
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
We report here that the expression of the transcription factor T-bet, which is known to be required for effector cytotoxic CD8+ T lymphocytes (CTL) generation and effector memory cell formation, is regulated in CTL by microRNA-155 (miR-155). Importan
Externí odkaz:
https://doaj.org/article/045e79ae899f4457b4050ae3c4bfc370
Autor:
Thijs J Schrama, Danique A. Laport, Caoimhe H. Kiernan, Manzhi Zhao, Bart J. A. Rijnders, Casper Rokx, Sebastiaan Van Bockstael, Maria C. Jaimes, Ling Li, Dwin G.B. Grashof, Christos A. Ouzounis, Merel E. P. Wilmsen, Daniel Alvarez de la Sierra, Harmen J.G. van de Werken, Tamara van Wees, Inge Brouwers-Haspels, Manuel Hernández-González, Melisa D. Castro Eiro, Marco W.J. Schreurs, Marjan van Meurs, Geoffrey Kraker, Yvonne M. Mueller, Ricardo Pujol-Borrell, Peter D. Katsikis, Harm de Wit, Rik Ruijten, Tessa Alofs
Quantitative or qualitative differences in immunity may drive and predict clinical severity in COVID-19. We therefore measured modules of serum pro-inflammatory, anti-inflammatory and anti-viral cytokines in combination with the anti-SARS-CoV-2 antib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ee7016575b8d7f20a18e3f8667441e0
https://doi.org/10.1101/2021.05.07.21256531
https://doi.org/10.1101/2021.05.07.21256531
Autor:
Jennifer L, Hope, Manzhi, Zhao, Christopher J, Stairiker, Caoimhe H, Kiernan, Alison J, Carey, Yvonne M, Mueller, Marjan, van Meurs, Inge, Brouwers-Haspels, Dennis C, Otero, Eun-Ah, Bae, Hannah A, Faso, Alex, Maas, Hans, de Looper, Paolo M, Fortina, Isidore, Rigoutsos, Linda M, Bradley, Stefan J, Erkeland, Peter D, Katsikis
Publikováno v:
J Immunol
MicroRNAs (miRNAs/miRs) are small, endogenous noncoding RNAs that are important post-transcriptional regulators with clear roles in the development of the immune system and immune responses. Using miRNA microarray profiling, we characterized the expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6638aed56934e24822095bea3ae5ecb8
https://pubmed.ncbi.nlm.nih.gov/35022277
https://pubmed.ncbi.nlm.nih.gov/35022277