Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Marja T Hyvönen"'
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 1, p e1002299 (2012)
Cholesteryl ester transfer protein (CETP) transports cholesteryl esters, triglycerides, and phospholipids between different lipoprotein fractions in blood plasma. The inhibition of CETP has been shown to be a sound strategy to prevent and treat the d
Externí odkaz:
https://doaj.org/article/2eadda8f583147b290927858ef3ba367
Autor:
Timo Vuorela, Andrea Catte, Perttu S Niemelä, Anette Hall, Marja T Hyvönen, Siewert-Jan Marrink, Mikko Karttunen, Ilpo Vattulainen
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 10, p e1000964 (2010)
We study the structure and dynamics of spherical high density lipoprotein (HDL) particles through coarse-grained multi-microsecond molecular dynamics simulations. We simulate both a lipid droplet without the apolipoprotein A-I (apoA-I) and the full H
Externí odkaz:
https://doaj.org/article/c096f962f5974054a358e10a66c90971
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 2, p e34 (2007)
The paradigm of biological membranes has recently gone through a major update. Instead of being fluid and homogeneous, recent studies suggest that membranes are characterized by transient domains with varying fluidity. In particular, a number of expe
Externí odkaz:
https://doaj.org/article/56c5c06b6bfc4fb4a8bdaa29a213fbfb
Publikováno v:
The Journal of Physical Chemistry B. 115:4818-4825
A force field has been previously designed for a dodecasaccharide chain of chondroitin-6-sulfate (C6S) and has proved to yield valuable data going from basic conformational properties to a more detailed H-bonding network. This force field is further
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e05ed45c65643f57bb39f95cd2de87
https://doi.org/10.1021/jp110987r
https://doi.org/10.1021/jp110987r
Autor:
Artturi Koivuniemi, Petri T. Kovanen, Katariina Lähdesmäki, O. H. Samuli Ollila, Marja T. Hyvönen
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1798(5):938-946
Phospholipids are key components of biological membranes and their lipolysis with phospholipase A2 (PLA2) enzymes occurs in different cellular pH environments. Since no studies are available on the effect of pH on PLA2-modified phospholipid membranes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f53817aa9c2e1e80f17a0adf0c3c7ff9
Publikováno v:
The Journal of Physical Chemistry B. 111:3139-3150
We elucidate the influence of unsaturation on single-component membrane properties, focusing on their dynamical aspects and lateral pressure profiles across the membrane. To this end, we employ atomistic molecular dynamics simulations to study five d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c37a82e3f28ed0b5fee6f1b3342593
https://doi.org/10.1021/jp065424f
https://doi.org/10.1021/jp065424f
Autor:
Marja T. Hyvönen, Michael Patra, Mohsen Sabouri-Ghomi, Emma Falck, Mikko Karttunen, Ilpo Vattulainen
Publikováno v:
Computer Physics Communications, 176(1), 14-22. Elsevier
University of Helsinki
University of Helsinki
Typical biomolecular systems such as cellular membranes, DNA, and protein complexes are highly charged. Thus, efficient and accurate treatment of electrostatic interactions is of great importance in computational modeling of such systems. We have emp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c1737489e22aa1c9c491359f061b9d
https://research.tue.nl/en/publications/b3aa583b-43e1-410c-8624-5256acbf3707
https://research.tue.nl/en/publications/b3aa583b-43e1-410c-8624-5256acbf3707
Publikováno v:
Biophysical Journal, 92(4), 1125-1137. Biophysical Society
The effects of cholesterol (Chol) on phospholipid bilayers include ordering of the fatty acyl chains, condensing of the lipids in the bilayer plane, and promotion of the liquid-ordered phase. These effects depend on the type of phospholipids in the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f71329d50fe6df340514831b762c0e3
https://doi.org/10.1529/biophysj.106.088427
https://doi.org/10.1529/biophysj.106.088427
Publikováno v:
Biophysical Journal. 90(7):2247-2257
We have conducted molecular dynamics simulations to gain insight into the atomic-scale properties of an isotropic system of cholesteryl oleate (CO) molecules. Cholesteryl esters are major constituents of low density lipoprotein particles, the key pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db6b191e187960908ec36ce3dba51027
Publikováno v:
University of Helsinki
Sphingomyelins (SMs) are among the most common phospholipid components of plasma membranes, usually constituting a mixture of several molecular species with various fatty acyl chain moieties. In this work, we utilize atomistic molecular dynamics simu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9258a1481dab2d8ca61bf0c0fd1b44da
https://doi.org/10.1529/biophysj.105.067371
https://doi.org/10.1529/biophysj.105.067371