Výsledky vyhledávání - "Marja Rutgers"

Akademický článek

Selective serotonin reuptake inhibitors (SSRIs) prevent meta-iodobenzylguanidine (MIBG) uptake in platelets without affecting neuroblastoma tumor uptake

Autor: Thomas Blom, Rutger Meinsma, Marja Rutgers, Corine Buitenhuis, Marieke Dekken-Van den Burg, André B. P. van Kuilenburg, Godelieve A. M. Tytgat

Publikováno v: EJNMMI Research, Vol 10, Iss 1, Pp 1-12 (2020)

Abstract Background The therapeutic use of [131I]meta-iodobenzylguanidine ([131I]MIBG) is often accompanied by hematological toxicity, mainly consisting of persistent and severe thrombocytopenia. While MIBG accumulates in neuroblastoma cells via sele

Externí odkaz: https://doaj.org/article/0e95c18dbaee417495963f09c52009dc

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Selective serotonin reuptake inhibitors (SSRIs) prevent meta-iodobenzylguanidine (MIBG) uptake in platelets without affecting neuroblastoma tumor uptake

Autor: Rutger Meinsma, Marja Rutgers, Marieke Dekken-Van den Burg, Thomas Blom, Godelieve A.M. Tytgat, Corine K.M. Buitenhuis, André B.P. van Kuilenburg

Publikováno v: EJNMMI research, 10(1):78. Springer Berlin
EJNMMI Research
EJNMMI Research, Vol 10, Iss 1, Pp 1-12 (2020)

Background The therapeutic use of [131I]meta-iodobenzylguanidine ([131I]MIBG) is often accompanied by hematological toxicity, mainly consisting of persistent and severe thrombocytopenia. While MIBG accumulates in neuroblastoma cells via selective upt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbcfbc144a08664293c72da9296916c5
https://pure.amc.nl/en/publications/selective-serotonin-reuptake-inhibitors-ssris-prevent-metaiodobenzylguanidine-mibg-uptake-in-platelets-without-affecting-neuroblastoma-tumor-uptake(e99bfeab-6f89-423c-aefe-d0cb19711392).html

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A comparison of targeting of neuroblastoma with mIBG and anti L1-CAM antibody mAb chCE7: therapeutic efficacy in a neuroblastoma xenograft model and imaging of neuroblastoma patients

Autor: Cornelis A. Hoefnagel, F. Carrel, M L Meli, J. de Kraker, Hanspeter Amstutz, Corine K.M. Buitenhuis, Lou A. Smets, Ilse Novak-Hofer, Marja Rutgers, Pius A. Schubiger

Publikováno v: European journal of nuclear medicine, 28(3), 359-368. Springer Verlag

Iodine-131 labelled anti L1-CAM antibody mAb chCE7 was compared with the effective neuroblastoma-seeking agent (131)I-labelled metaiodobenzylguanidine (MIBG) with regard to (a) its therapeutic efficacy in treating nude mice with neuroblastoma xenogra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7602706061ef3351d3440e577ab1d335
https://doi.org/10.1007/s002590000454

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[131I]- and [125I]metaiodobenzylguanidine therapy in macroscopic and microscopic tumors:A comparative study in SK-N-SH human neuroblastoma and PC12 rat pheochromocytoma xenografts

Autor: Corine K.M. Buitenhuis, P.A. Voûte, Lou A. Smets, Martin van der Valk, Cees A. Hoefnagel, Marja Rutgers

Publikováno v: International Journal of Cancer. 90:312-325

[(131)I]Metaiodobenzylguanidine ([(131)I]MIBG) targeted radiotherapy is effective in debulking childhood neuroblastoma. The high-energy beta-emitter [(131)I]MIBG is, however, not very well suited to treat submillimeter tumors. The [(125)I]MIBG emissi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::836071951bb1dc5338aaed78d322ca2f
https://doi.org/10.1002/1097-0215(20001220)90:6<312::aid-ijc2>3.0.co

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Targeting of meta-iodobenzylguanidine to SK-N-SH human neuroblastoma xenografts: Tissue distribution, metabolism and therapeutic efficacy

Autor: P.A. Voûte, Corine K.M. Buitenhuis, Marja Rutgers, Cees A. Hoefnagel, Lou A. Smets

Publikováno v: International Journal of Cancer. 87:412-422

The clinical results of [(131)I]meta-iodobenzylguanidine (MIBG)-targeted radiotherapy in neuroblastoma patients is highly variable. To assess the therapeutic potential of [(131)I]MIBG, we used the SK-N-SH human neuroblastoma, xenografted in nude mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee481261b6ddd7573fc829d0b581cdba
https://doi.org/10.1002/1097-0215(20000801)87:3<412::aid-ijc16>3.0.co

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Meta-iodobenzylguanidine uptake in platelets, megakaryoblastic leukaemia cell lines MKPL-1 and CHRF-288-11 and erythroleukaemic cell line HEL

Autor: Marja Rutgers, S. Takeuchi, I. Miyoshi, P.A. Voǔte, Godelieve A.M. Tytgat

Publikováno v: European Journal of Cancer. 31:603-606

The major toxicity encountered with [131I]-Meta-iodobenzylguanidine (MIBG) therapy in neuroblastoma patients is an often isolated thrombocytopenia. We believe that this results from MIBG-induced radiotoxicity of the megakaryocytes. Since it is diffic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7df3909c36c3c5fb76349f51a3a037a
https://doi.org/10.1016/0959-8049(95)00058-q

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Deiodination of Iodothyronine Sulfamates by Type I Iodothyronine Deiodinase of Rat Liver*

Autor: Marja Rutgers, Theo J. Visser, Frank A. Heusdens

Publikováno v: Endocrinology. 129:1375-1381

The substrate behavior of synthetic N-sulfonated iodothyronines (iodothyronine sulfamates, TiNS) for the type I deiodinase was compared with that of the naturally occurring 4'-O-sulfonated iodothyronines (iodothyronine sulfates, TiS), which have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7503bd173a8465a88e17f736a9093d4
https://doi.org/10.1210/endo-129-3-1375

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Pharmacokinetics and intracellular distribution of the tumor-targeted radiopharmaceuticalm-iodo-benzylguanidine in SK-N-SH neuroblastoma and PC-12 pheochromocytoma cells

Autor: Karin Ritzen, Corine K.M. Buitenhuis, Lou A. Smets, Marja Rutgers, Manon Janssen

Publikováno v: International Journal of Cancer. 48:609-615

Radiodinated meta-iodobenzylguandine (MIBG) is increasingly used for the diagnosis and targeted radiotherapy of neuro-adrenergic tumors. We have investigated various conditions for specific tumor loading and prolonged retention of this radiopharmaceu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e7a1ad7db13110d5061a26df8411f8
https://doi.org/10.1002/ijc.2910480421

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The role of sulfation in thyroid hormone metabolism

Autor: Sebo Jan Eelkman Rooda, Wouter W. de Herder, Marja Rutgers, Theo J. Visser, Joop C.J. van Buuren

Publikováno v: Trends in Endocrinology & Metabolism. 1:211-218

Sulfate conjugation is a significant metabolic reaction for thyroxine and especially so for triiodothyronine and lower iodothyronines in rats. Triiodothyronine sul fation has also been demonstrated in humans. Sulfation accelerates the deiodinative br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7a755cb18b4216e4491d8fa13f7de58
https://doi.org/10.1016/1043-2760(90)90055-8

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Human megakaryocytes cultured in vitro accumulate serotonin but not meta-iodobenzylguanidine whereas platelets concentrate both

Autor: Marieke Dekker van den Brug, Lou A. Smets, Marja Rutgers, P.A. Voûte, Godelieve A.M. Tytgat

Publikováno v: Experimental hematology, 30(6), 555-563. Elsevier Inc.

Objective. Thrombocytopenia is the major toxicity of radio-iodinated meta-iodobenzylguanidine (MIBG) therapy in patients with recurrent neuroblastoma. MIBG is taken up in platelets via the serotonin transporter. Given the delayed appearance and long

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b0f554774ee3a05668790b4abea5b4
https://pubmed.ncbi.nlm.nih.gov/12063022

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