Pilus PilA of the naturally competent HACEK group pathogen Aggregatibacter actinomycetemcomitans stimulates human leukocytes and interacts with both DNA and proinflammatory cytokines

Autor: Esra Bozkurt, Anders Johansson, Nelli Vahvelainen, Terhi Maula, Riikka Ihalin, Marja Pöllänen

Each HACEK group pathogen, which can cause infective endocarditis, expresses type IVa pili. The type IVa major pilin PilA plays a role in bacterial colonization, virulence, twitching motility, and the uptake of extracellular DNA. The type IV prepilin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faba1a6c4bf285db4ca23ed2bce6d7cb
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-200654

Environmental Stimuli Shape Biofilm Formation and the Virulence of Periodontal Pathogens

Autor: Marja Pöllänen, Annamari Paino, Riikka Ihalin

Publikováno v: International Journal of Molecular Sciences, Vol 14, Iss 8, Pp 17221-17237 (2013)
International Journal of Molecular Sciences

Periodontitis is a common inflammatory disease affecting the tooth-supporting structures. It is initiated by bacteria growing as a biofilm at the gingival margin, and communication of the biofilms differs in health and disease. The bacterial composit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0160ba2a00dc897241a7fad238e83375
https://doi.org/10.3390/ijms140817221

A novel organotypic dento-epithelial culture model: effect of Fusobacterium nucleatum biofilm on B-defensin-2, -3, and LL-37 expression

Autor: Ulvi Kahraman Gursoy, Veli-Jukka Uitto, Marja Pöllänen, Eija Könönen

Publikováno v: Journal of Periodontology. 83(2):242-247

In the present study, the expression and localization of three epithelial peptides (human β-defensin [hBD]-2 and -3, and cathelicidin [LL-37]) are studied in an organotypic dento-epithelial (OD-E) model exposed to Fusobacterium nucleatum (Fn) biofil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9feedb660b2e542d5bbfb5f93149ed
https://doi.org/10.1902/jop.2011.110177

Effect of short chain fatty acids on human gingival epithelial cell keratins in vitro

Autor: Marja Pöllänen, Jukka I. Salonen

Publikováno v: European Journal of Oral Sciences. 108:523-529

Hemidesmosomal attachment of the junctional epithelial cells to the tooth and the ability of the attached cells to divide are essential features of the healthy dentogingival junction. Short chain fatty acids are bacterial metabolites associated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e9750ed6c8e59eb9db9733e3f2d1c68e
https://doi.org/10.1034/j.1600-0722.2000.00881.x

Interleukin-1β is internalised by viable Aggregatibacter actinomycetemcomitans biofilm and locates to the outer edges of nucleoids

Autor: Marja Pöllänen, Raija Sormunen, Annamari Paino, Heidi Tuominen, Jari Korhonen, Elina Lohermaa, Riikka Ihalin

Publikováno v: Cytokine. 60(2)

The opportunistic pathogen Aggregatibacter actinomycetemcomitans causes periodontitis, which is a biofilm infection that destroys tooth-supportive tissues. Interleukin (IL)-1β, a central proinflammatory cytokine of periodontitis, is an essential fir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e314aee4c5857f364e545ec5650ce9
https://pubmed.ncbi.nlm.nih.gov/22898394