Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Marja Kreike"'
Autor:
Annelies Demeyer, Elien Van Nuffel, Griet Baudelet, Yasmine Driege, Marja Kreike, David Muyllaert, Jens Staal, Rudi Beyaert
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
MALT1 plays an important role in innate and adaptive immune signaling by acting as a scaffold protein that mediates NF-κB signaling. In addition, MALT1 is a cysteine protease that further fine tunes proinflammatory signaling by cleaving specific sub
Externí odkaz:
https://doaj.org/article/d20973f6d50e422aabc6d8f4e9ac7160
Autor:
Annelies Demeyer, Ioannis Skordos, Yasmine Driege, Marja Kreike, Tino Hochepied, Mathijs Baens, Jens Staal, Rudi Beyaert
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
MALT1 is a central signaling component in innate and adaptive immunity by regulating NF-κB and other key signaling pathways in different cell types. Activities of MALT1 are mediated by its scaffold and protease functions. Because of its role in lymp
Externí odkaz:
https://doaj.org/article/d60c8053741f489185924cb3921ba44f
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
CYLD is a deubiquitinating enzyme that plays a crucial role in immunity and inflammation as a negative regulator of NF-κB transcription factor and JNK kinase signaling. Defects in either of these pathways contribute to the progression of numerous in
Externí odkaz:
https://doaj.org/article/6a59ba0eec1c4a27a8829d1d30fb4b74
Autor:
Laura Meloni, Lynn Verstrepen, Marja Kreike, Jens Staal, Yasmine Driege, Inna S. Afonina, Rudi Beyaert
Publikováno v:
Molecules, Vol 23, Iss 12, p 3144 (2018)
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is an intracellular cysteine protease (paracaspase) that plays an integral role in innate and adaptive immunity. The phenothiazine mepazine has been shown to inhibit the prote
Externí odkaz:
https://doaj.org/article/9d245db533fa4859b36b751093580da1
Autor:
Aurora Holgado, Zhuangzhuang Liu, Aigerim Aidarova, Christina Mueller, Mira Haegman, Yasmine Driege, Marja Kreike, Charlotte L. Scott, Inna S. Afonina, Rudi Beyaert
Publikováno v:
Journal of Allergy and Clinical Immunology.
Autor:
Ioannis Skordos, Yasmine Driege, Mira Haegman, Marja Kreike, Jens Staal, Annelies Demeyer, Rudi Beyaert
Publikováno v:
FEBS JOURNAL
The uniqueness of MALT1 protease activity in controlling several aspects of immunity in humans has made it a very attractive therapeutic target for multiple autoimmune diseases and lymphoid malignancies. Despite several encouraging preclinical studie
Autor:
Mira Haegman, Marja Kreike, Harald Braun, Rudi Beyaert, Inna S. Afonina, Marie Lork, Jens Staal, Yasmine Driege, Domien Vanneste, Styliani Iliaki
Publikováno v:
The FEBS Journal. 288:1630-1647
Signal transduction typically displays a so-called bow-tie topology: Multiple receptors lead to multiple cellular responses but the signals all pass through a narrow waist of central signaling nodes. One such signaling node for several inflammatory a
Autor:
Griet Baudelet, Jens Staal, Elien Van Nuffel, Rudi Beyaert, Yasmine Driege, Marja Kreike, Inna S. Afonina
Publikováno v:
EMBO reports. 17:914-927
Mutations in CARD14 have recently been linked to psoriasis susceptibility. CARD14 is an epidermal regulator of NF‐κB activation. However, the ability of CARD14 to activate other signaling pathways as well as the biochemical mechanisms that mediate
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
CYLD is a deubiquitinating enzyme that plays a crucial role in immunity and inflammation as a negative regulator of NF-κB transcription factor and JNK kinase signaling. Defects in either of these pathways contribute to the progression of numerous in
Autor:
Tobias Kensche, Isabelle Carpentier, Kelly Verhelst, Marja Kreike, Rudi Beyaert, Laura Meloni, Lynn Verstrepen, Ivan Dikic
Publikováno v:
The EMBO Journal. 31:3845-3855
Linear polyubiquitination of proteins has recently been implicated in NF-κB signalling and is mediated by the linear ubiquitin chain assembly complex (LUBAC), consisting of HOIL-1, HOIP and Sharpin. However, the mechanisms that regulate linear ubiqu