Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Marja Koskuvi"'
Autor:
Noora Räsänen, Jari Tiihonen, Marja Koskuvi, Šárka Lehtonen, Nelli Jalkanen, Nelli Karmila, Isabelle Weert, Olli Vaurio, Ilkka Ojansuu, Markku Lähteenvuo, Olli Pietiläinen, Jari Koistinaho
Publikováno v:
Biological Psychiatry Global Open Science, Vol 4, Iss 4, Pp 100313- (2024)
Background: Development of synaptic activity is a key neuronal characteristic that relies largely on interactions between neurons and astrocytes. Although astrocytes have known roles in regulating synaptic function and malfunction, the use of human-
Externí odkaz:
https://doaj.org/article/e7359c272ddf44e5beee97c07010e73c
Autor:
Riikka Lampinen, Irina Belaya, Liudmila Saveleva, Jeffrey R. Liddell, Dzhessi Rait, Mikko T. Huuskonen, Raisa Giniatullina, Annika Sorvari, Liisi Soppela, Nikita Mikhailov, Isabella Boccuni, Rashid Giniatullin, Marcela Cruz-Haces, Julia Konovalova, Marja Koskuvi, Andrii Domanskyi, Riikka H. Hämäläinen, Gundars Goldsteins, Jari Koistinaho, Tarja Malm, Sweelin Chew, Kirsi Rilla, Anthony R. White, Nicholas Marsh-Armstrong, Katja M. Kanninen
Publikováno v:
Neurobiology of Disease, Vol 170, Iss , Pp 105753- (2022)
Under physiological conditions in vivo astrocytes internalize and degrade neuronal mitochondria in a process called transmitophagy. Mitophagy is widely reported to be impaired in neurodegeneration but it is unknown whether and how transmitophagy is a
Externí odkaz:
https://doaj.org/article/90b3b33e12fd4d749b99c1ac7e4e3bbb
Autor:
Tuuli-Maria Sonninen, Riikka H. Hämäläinen, Marja Koskuvi, Minna Oksanen, Anastasia Shakirzyanova, Sara Wojciechowski, Katja Puttonen, Nikolay Naumenko, Gundars Goldsteins, Nihay Laham-Karam, Marko Lehtonen, Pasi Tavi, Jari Koistinaho, Šárka Lehtonen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract In Parkinson`s disease (PD), the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta is associated with Lewy bodies arising from the accumulation of alpha-synuclein protein which leads ultimately to movement impairment. W
Externí odkaz:
https://doaj.org/article/fcb1196617224db18b53e46c1fc7df9b
Autor:
Henna Jäntti, Minna Oksanen, Pinja Kettunen, Stella Manta, Lionel Mouledous, Hennariikka Koivisto, Johanna Ruuth, Kalevi Trontti, Hiramani Dhungana, Meike Keuters, Isabelle Weert, Marja Koskuvi, Iiris Hovatta, Anni-Maija Linden, Claire Rampon, Tarja Malm, Heikki Tanila, Jari Koistinaho, Taisia Rolova
Publikováno v:
Cells, Vol 11, Iss 24, p 4116 (2022)
The PSEN1 ΔE9 mutation causes a familial form of Alzheimer’s disease (AD) by shifting the processing of amyloid precursor protein (APP) towards the generation of highly amyloidogenic Aβ42 peptide. We have previously shown that the PSEN1 ΔE9 muta
Externí odkaz:
https://doaj.org/article/32d6b7b081a84028b01d9a606f0770d8
Autor:
Jari Tiihonen, Marja Koskuvi, Markus Storvik, Ida Hyötyläinen, Yanyan Gao, Katja A. Puttonen, Raisa Giniatullina, Ekaterina Poguzhelskaya, Ilkka Ojansuu, Olli Vaurio, Tyrone D. Cannon, Jouko Lönnqvist, Sebastian Therman, Jaana Suvisaari, Jaakko Kaprio, Lesley Cheng, Andrew F. Hill, Markku Lähteenvuo, Jussi Tohka, Rashid Giniatullin, Šárka Lehtonen, Jari Koistinaho
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Noise due to genetic heterogeneity potentially impacts the the discovery of genes that contribute to diseases such as schizophrenia (SCZ). In this study, authors minimize the disease-irrelevant noise between SCZ and healthy individuals by profiling t
Externí odkaz:
https://doaj.org/article/61016b2a66ea4dce8f5588786287831c
Autor:
Taisia Rolova, Ying-Chieh Wu, Marja Koskuvi, Jenni Voutilainen, Tuuli-Maria Sonninen, Johanna Kuusisto, Markku Laakso, Riikka H. Hämäläinen, Jari Koistinaho, Šárka Lehtonen
Publikováno v:
Stem Cell Research, Vol 48, Iss , Pp 101968- (2020)
A673T mutation in the amyloid precursor protein (APP) is a rare variant associated with a reduced risk of late-onset Alzheimer‘s disease (AD) and age-related cognitive decline. The A673T mutation decreases beta-amyloid (Aβ) production and aggregat
Externí odkaz:
https://doaj.org/article/c32ee305c959417fb0b382031e1c9e2e
Autor:
Ilkka Fagerlund, Antonios Dougalis, Anastasia Shakirzyanova, Mireia Gómez-Budia, Anssi Pelkonen, Henna Konttinen, Sohvi Ohtonen, Mohammad Feroze Fazaludeen, Marja Koskuvi, Johanna Kuusisto, Damián Hernández, Alice Pebay, Jari Koistinaho, Tuomas Rauramaa, Šárka Lehtonen, Paula Korhonen, Tarja Malm
Publikováno v:
Cells, Vol 11, Iss 1, p 124 (2021)
Human cerebral organoids, derived from induced pluripotent stem cells, offer a unique in vitro research window to the development of the cerebral cortex. However, a key player in the developing brain, the microglia, do not natively emerge in cerebral
Externí odkaz:
https://doaj.org/article/51d43edc458d422caf349e2f8da0e316
Autor:
Nelli-Noora Välimäki, Abdulhameed Bakreen, Sara Häkli, Hiramani Dhungana, Meike H. Keuters, Yannick Dunlop, Marja Koskuvi, Velta Keksa-Goldsteine, Minna Oksanen, Henna Jäntti, Šárka Lehtonen, Tarja Malm, Jari Koistinaho, Jukka Jolkkonen
Publikováno v:
Stroke. 53:3192-3201
Background: Species-specific differences in astrocytes and their Alzheimer disease-associated pathology may influence cellular responses to other insults. Herein, human glial chimeric mice were generated to evaluate how Alzheimer disease predisposing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3030cbc40910164bf83f0cc2c828baa
https://doi.org/10.1161/strokeaha.122.039700
https://doi.org/10.1161/strokeaha.122.039700
Autor:
Frank Edenhofer, Angeliki Spathopoulou, Gabriella Fenkart, Valentin Marteau, Martina Podlesnic, Katharina Kruszewski, Marja Koskuvi, János Réthelyi, Ágota Apáti, Luciano Conti, Manching Ku, Therese Koal, Udo Müller, Radu Talmazan, Ilkka Ojansuu, Olli Vaurio, Markku Lähteenvuo, Šárka Lehtonen, Jerome Mertens, Katharina Günther, Jari Tiihonen, Jari Koistinaho, Zlatko Trajanoski
Schizophrenia is a neuropsychiatric disorder, caused by a combination of genetic and environmental factors. Recently, metabolomic studies based on patients’ biofluids and post-mortem brain specimens have revealed altered levels of distinct metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::708880bae100ce86a59ab0ccdced3931
https://doi.org/10.21203/rs.3.rs-2175912/v1
https://doi.org/10.21203/rs.3.rs-2175912/v1
Autor:
Jari Koistinaho, Marja Koskuvi, Elina Pörsti, Ying Chieh Wu, Kalevi Trontti, Amanda McQuade, Ilkka Ojansuu, Tyrone Cannon, Jouko Lönnqvist, Sebastian Therman, Jaana Suvisaari, Jaakko Kaprio, Mathew Blurton-Jones, Iiris Hovatta, Markku Lähteenvuo, Taisia Rolova, Sarka Lehtonen, Jari Tiihonen
Several lines of evidence indicate the involvement of neuroinflammatory processes in the pathophysiology of schizophrenia (SCZ). Microglia are brain resident immune cells responding toward invading pathogens and injury-related products, and additiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb5d50343397f16930d284264b38c023
https://doi.org/10.21203/rs.3.rs-1980131/v1
https://doi.org/10.21203/rs.3.rs-1980131/v1