Zobrazeno 1 - 1
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pro vyhledávání: '"Marja Jaurakkajärvi"'
Autor:
Tomi Järvinen, Hanna Kumpulainen, Hannu Raunio, Risto O. Juvonen, Marja Jaurakkajärvi, Jouko Vepsäläinen, Niina Mähönen, Jarkko Rautio, Marja-Leena Laitinen
Publikováno v:
Journal of Medicinal Chemistry. 49:1207-1211
Hydroxyimine derivatives of ketoprofen (1) and nabumetone (2) were synthesized and evaluated in vitro and in vivo as cytochrome P450-selective intermediate prodrug structures of ketones. 2 released nabumetone in vitro in the presence of isolated rat