An epigenetic and transcriptomic signature of immune tolerance in human monocytes through multi-omics integration

Autor: Xanthe Brands, Bastiaan W. Haak, Augustijn M. Klarenbeek, Joe Butler, Fabrice Uhel, Wanhai Qin, Natasja A. Otto, Marja E. Jakobs, Daniël R. Faber, René Lutter, W. Joost Wiersinga, Tom van der Poll, Brendon P. Scicluna

Publikováno v: Genome Medicine, Vol 13, Iss 1, Pp 1-17 (2021)

Abstract Background The plasticity of monocytes enables them to exert multiple roles during an immune response, including promoting immune tolerance. How monocytes alter their functions to convey immune tolerance in the context of lower respiratory t

Externí odkaz: https://doaj.org/article/b06b9c428497488dbd62d7b688aaab55

Metagenomic DNA sequencing for semi-quantitative pathogen detection from urine:a prospective, laboratory-based, proof-of-concept study

Autor: Victoria A Janes, Sébastien Matamoros, Patrick Munk, Philip T L C Clausen, Sylvie M Koekkoek, Linda A M Koster, Marja E Jakobs, Bob de Wever, Caroline E Visser, Frank M Aarestrup, Ole Lund, Menno D de Jong, Patrick M M Bossuyt, Daniel R Mende, Constance Schultsz

Publikováno v: Janes, V A, Matamoros, S B, Munk, P, Clausen, P T L C, Koekkoek, S M, Koster, L A M, Jakobs, M E, de Wever, B, Visser, C E, Aarestrup, F M, Lund, O, de Jong, M D, Bossuyt, P M M, Mende, D R & Schultsz, C 2022, ' Metagenomic DNA sequencing for semi-quantitative pathogen detection from urine : a prospective, laboratory-based, proof-of-concept study ', The Lancet Microbe, vol. 3, no. 8, pp. e588-e597 . https://doi.org/10.1016/S2666-5247(22)00088-X
Janes, V A, Matamoros, S, Munk, P, Clausen, P T L C, Koekkoek, S M, Koster, L A M, Jakobs, M E, de Wever, B, Visser, C E, Aarestrup, F M, Lund, O, de Jong, M D, Bossuyt, P M M, Mende, D R & Schultsz, C 2022, ' Metagenomic DNA sequencing for semi-quantitative pathogen detection from urine : a prospective, laboratory-based, proof-of-concept study ', Lancet. Microbe, vol. 3, no. 8, pp. e588-e597 . https://doi.org/10.1016/S2666-5247(22)00088-X
The Lancet. Microbe, 3(8), e588-e597. Elsevier Ltd
The Lancet Microbe, 3(8), e588-e597. Elsevier Ltd

BackgroundSemi-quantitative bacterial culture is the reference standard to diagnose urinary tract infection, but culture is time-consuming and can be unreliable if patients are receiving antibiotics. Metagenomics could increase diagnostic accuracy an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c656416815f6e884a5d9cb570c878289
https://research.vumc.nl/en/publications/5752c867-80df-45eb-b348-08b4521fafeb

Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian

Autor: Frank J. T. Staal, Erik B. van den Akker, Marcel J. T. Reinders, Marja E. Jakobs, Stavros Makrodimitris, Frank Baas, Henne Holstege, Quinten Waisfisz, P. Eline Slagboom, Martijn H. Brugman, Ted Bradley, Daphne de Jong, Tatjana Nikolic, Marc Hulsman

Publikováno v: Leukemia
Leukemia, 35, 2125-2129. SPRINGERNATURE
van den Akker, E B, Makrodimitris, S, Hulsman, M, Brugman, M H, Nikolic, T, Bradley, T, Waisfisz, Q, Baas, F, Jakobs, M E, de Jong, D, Slagboom, P E, Staal, F J T, Reinders, M J T & Holstege, H 2021, ' Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian ', Leukemia, vol. 35, no. 7, pp. 2125-2129 . https://doi.org/10.1038/s41375-020-01086-0
Leukemia, 35(7), 2125-2129. Nature Publishing Group
Leukemia, 35 (2021)(7)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353fc505e74566f77a7d574d1921b161
https://pubmed.ncbi.nlm.nih.gov/33184493

Amplified fragment length polymorphism and whole genome sequencing: A comparison of methods in the investigation of a nosocomial outbreak with vancomycin resistant enterococci

Autor: Daan W. Notermans, Robin van Houdt, Menno D. de Jong, Marja E. Jakobs, Victoria A. Janes, Constance Schultsz, Caroline E. Visser, Ingrid J B Spijkerman, Sébastien Matamoros, Rob J. L. Willems

Publikováno v: Janes, V A, Notermans, D W, Spijkerman, I J B, Visser, C E, Jakobs, M E, van Houdt, R, Willems, R J L, de Jong, M D, Schultsz, C & Matamoros, S B 2019, ' Amplified fragment length polymorphism and whole genome sequencing: A comparison of methods in the investigation of a nosocomial outbreak with vancomycin resistant enterococci ', Antimicrobial Resistance and Infection Control, vol. 8, no. 1, 153 . https://doi.org/10.1186/s13756-019-0604-5
Antimicrobial Resistance and Infection Control, 8(1):153. BioMed Central
Antimicrobial Resistance and Infection Control, Vol 8, Iss 1, Pp 1-8 (2019)
Antimicrobial Resistance and Infection Control
Antimicrobial Resistance and Infection Control, 8(1). BioMed Central Ltd.
Antimicrobial resistance and infection control, 8(1):153. BioMed Central

Background Recognition of nosocomial outbreaks with antimicrobial resistant (AMR) pathogens and appropriate infection prevention measures are essential to limit the consequences of AMR pathogens to patients in hospitals. Because unrelated, but geneti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c285c5597a914be02a935c126a63ec
https://doi.org/10.1186/s13756-019-0604-5

Streptococcus pneumoniae Arginine Synthesis Genes Promote Growth and Virulence in Pneumococcal Meningitis

Autor: Kim Schipper, Yvonne Pannekoek, Arie van der Ende, Tom van der Poll, Aeilko H. Zwinderman, Jurgen R. Piet, Marja E. Jakobs, Antoine H. C. van Kampen, Frank Baas, Matthijs C. Brouwer, Mercedes Valls Serón, Madelijn Geldhoff, Diederik van de Beek, Barbera D. C. van Schaik

Publikováno v: Journal of infectious diseases, 209(11), 1781-1791. Oxford University Press
Journal of Infectious Diseases
The Journal of Infectious Diseases, 209(11), 1781-1791. Oxford University Press

Streptococcus pneumoniae (pneumococcus) is a major human pathogen causing pneumonia, sepsis and bacterial meningitis. Using a clinical phenotype based approach with bacterial whole-genome sequencing we identified pneumococcal arginine biosynthesis ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da253c260423436dce545ec326c4f3c
https://doi.org/10.1093/infdis/jit818